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Table 2 Effect of interventions on primary and secondary endpoints

From: Combination antibiotic therapy versus monotherapy in the treatment of acute exacerbations of chronic obstructive pulmonary disease: an open-label randomized trial

End Point Monotherapy (n = 79) Combination therapy (n = 60) P-value#
Clinical success on Day 10, no. (%) 48 (60.7) 36 (60) 1
Clinical success on Day 20, no. (%) 70(88.6) 53 (88.3) 1
FEV1, L
 FEV1 on Day 1 0.75 ± 0.19 0.73 ± 0.21 0.22
 ΔFEV1 on Day 10 0.17 ± 0.21 0.20 ± 0.26 0.24
 ΔFEV1 on Day 20 0.18 ± 0.28 0.24 ± 0.25 0.56
VAS score
 ΔVAS score on Day 10 − 10.6 ± 9.6 − 10.5 ± 13.3 0.92
 ΔVAS score on Day 20 − 21.3 ± 15.1 − 23.8 ± 17.6 0.26
CRP (mg/L)
 ΔCRP on Day 10 − 13.5 ± 14.3 − 12.6 ± 16.1 0.099
 ΔCRP on Day 20 − 22.1 ± 14.5 − 26.9 ± 15.7 0.004
  1. FEV1 postbronchodilator forced expiratory volume in 1 s
  2. #Fisher’s Exact Test for propotion comparison; Mann–Whitney test for comparing the means