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Table 2 Changes in outcomes after interventions 1 and 2 using segmented regression analysis (2008–2018)

From: Impact of a hospital-wide computerised approach to optimise the quality of antimicrobial prescriptions in patients with severe obesity: a quasi-experimental study

BMI

Outcomes

Intercept at time zero (95% CI)

p

Trend (95% CI)

p

Level change after Int1a (95% CI)

p

Trend change after Int1b (95% CI)

p

Level change after Int2a (95% CI)

p

Trend change after Int2b (95% CI)

p

 < 30

Proportion of inappropriate DOT (%)

4.6 (4.4 to 4.9)

 < 0.001

−0.0004 (−0.01 to 0.01)

0.9

−1.1 (−1.5 to −0.7)

 < 0.001

NS

 

NS

 

NS

 

DOT per 1000 PD

436.1 (381.0 to 491.2)

 < 0.001

14.9 (7.2 to 22.6)

 < 0.001

-78.7 (-137.9 to -19.5)

0.01

−16.1 (−23.7 to −8.4)

 < 0.001

NS

 

NS

 

DDD per 1000 PD

360.7 (313.7 to 407.7)

 < 0.001

4.1 (−0.3 to 8.5)

0.07

NS

 

−6.2 (−11.1 to −1.2)

0.02

NS

 

NS

 

LOS (days)

8.0 (7.6 to 8.3)

 < 0.001

0.03 (0.02 to 0.04)

 < 0.001

NS

 

NS

 

NS

 

NS

 

30–39.9

Proportion of inappropriate DOT (%)

7.0 (6.2 to 7.8)

 < 0.001

−0.06 (−0.1 to −0.02)

0.003

NS

 

NS

 

1.3 (−0.03 to 2.6)

0.056

NS

 

DOT per 1000 PD

364.1 (328.8 to 399.4)

 < 0.001

16.4 (11.6 to 21.3)

 < 0.001

−88.0 (−126.8 to −49.1)

 < 0.001

−16.6 (−21.5 to -11.7)

 < 0.001

−96.1 (−126.3 to −65.9)

 < 0.001

NS

 

DDD per 1000 PD

236.3 (202.1 to 270.6)

 < 0.001

19.7 (15.0 to 24.5)

 < 0.001

−107.5 (−147.9 to −67.1)

 < 0.001

−22.1 (−26.8 to −17.4)

 < 0.001

−78.6 (−106.1 to −51.1)

 < 0.001

2.8 (1.0 to 4.6)

0.004

LOS (days)

8.5 (7.7 to 9.4)

 < 0.001

−0.01 (−0.05 to 0.03)

0.5

NS

 

NS

 

3.6 (2.3 to 4.9)

 < 0.001

−0.1 (−0.2 to −0.07)

 < 0.001

 ≥ 40

Proportion of inappropriate DOT (%)

11.3 (8.2 to 14.5)

 < 0.001

0.7 (0.4 to 0.9)

 < 0.001

NS

 

−0.8 (−1.1 to −0.5)

 < 0.001

NS

 

NS

 

DOT per 1000 PD

615.0 (569.4 to 660.6)

 < 0.001

−7.1 (−10.5 to −3.7)

 < 0.001

114.9 (24.6 to 205.3)

0.01

NS

 

NS

 

7.9 (1.7 to 14.2)

0.01

DDD per 1000 PD

496.7 (456.8 to 536.6)

 < 0.001

−9.9 (−12.9 to −6.9)

 < 0.001

180.0 (100.3 to 259.7)

 < 0.001

NS

 

NS

 

12.6 (7.1 to 18.0)

 < 0.001

LOS (days)

11.5 (9.9 to 13.1)

 < 0.001

0.1 (0.04 to 0.2)

0.001

−4.7 (−7.3 to −2.1)

0.001

NS

 

NS

 

NS

 
  1. CI, confidence interval; DDD, defined daily dose; DOT, days of therapy; Int1, intervention 1; Int2, intervention 2; LOS, length of stay; NS, not statistically significant; PD, inpatient day
  2. aMeasure of immediate impact of the intervention; bMeasure of long-term impact of the intervention
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BMC Infectious Diseases

ISSN: 1471-2334

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