Skip to main content

Table 2 Changes in outcomes after interventions 1 and 2 using segmented regression analysis (2008–2018)

From: Impact of a hospital-wide computerised approach to optimise the quality of antimicrobial prescriptions in patients with severe obesity: a quasi-experimental study

BMI Outcomes Intercept at time zero (95% CI) p Trend (95% CI) p Level change after Int1a (95% CI) p Trend change after Int1b (95% CI) p Level change after Int2a (95% CI) p Trend change after Int2b (95% CI) p
 < 30 Proportion of inappropriate DOT (%) 4.6 (4.4 to 4.9)  < 0.001 −0.0004 (−0.01 to 0.01) 0.9 −1.1 (−1.5 to −0.7)  < 0.001 NS   NS   NS  
DOT per 1000 PD 436.1 (381.0 to 491.2)  < 0.001 14.9 (7.2 to 22.6)  < 0.001 -78.7 (-137.9 to -19.5) 0.01 −16.1 (−23.7 to −8.4)  < 0.001 NS   NS  
DDD per 1000 PD 360.7 (313.7 to 407.7)  < 0.001 4.1 (−0.3 to 8.5) 0.07 NS   −6.2 (−11.1 to −1.2) 0.02 NS   NS  
LOS (days) 8.0 (7.6 to 8.3)  < 0.001 0.03 (0.02 to 0.04)  < 0.001 NS   NS   NS   NS  
30–39.9 Proportion of inappropriate DOT (%) 7.0 (6.2 to 7.8)  < 0.001 −0.06 (−0.1 to −0.02) 0.003 NS   NS   1.3 (−0.03 to 2.6) 0.056 NS  
DOT per 1000 PD 364.1 (328.8 to 399.4)  < 0.001 16.4 (11.6 to 21.3)  < 0.001 −88.0 (−126.8 to −49.1)  < 0.001 −16.6 (−21.5 to -11.7)  < 0.001 −96.1 (−126.3 to −65.9)  < 0.001 NS  
DDD per 1000 PD 236.3 (202.1 to 270.6)  < 0.001 19.7 (15.0 to 24.5)  < 0.001 −107.5 (−147.9 to −67.1)  < 0.001 −22.1 (−26.8 to −17.4)  < 0.001 −78.6 (−106.1 to −51.1)  < 0.001 2.8 (1.0 to 4.6) 0.004
LOS (days) 8.5 (7.7 to 9.4)  < 0.001 −0.01 (−0.05 to 0.03) 0.5 NS   NS   3.6 (2.3 to 4.9)  < 0.001 −0.1 (−0.2 to −0.07)  < 0.001
 ≥ 40 Proportion of inappropriate DOT (%) 11.3 (8.2 to 14.5)  < 0.001 0.7 (0.4 to 0.9)  < 0.001 NS   −0.8 (−1.1 to −0.5)  < 0.001 NS   NS  
DOT per 1000 PD 615.0 (569.4 to 660.6)  < 0.001 −7.1 (−10.5 to −3.7)  < 0.001 114.9 (24.6 to 205.3) 0.01 NS   NS   7.9 (1.7 to 14.2) 0.01
DDD per 1000 PD 496.7 (456.8 to 536.6)  < 0.001 −9.9 (−12.9 to −6.9)  < 0.001 180.0 (100.3 to 259.7)  < 0.001 NS   NS   12.6 (7.1 to 18.0)  < 0.001
LOS (days) 11.5 (9.9 to 13.1)  < 0.001 0.1 (0.04 to 0.2) 0.001 −4.7 (−7.3 to −2.1) 0.001 NS   NS   NS  
  1. CI, confidence interval; DDD, defined daily dose; DOT, days of therapy; Int1, intervention 1; Int2, intervention 2; LOS, length of stay; NS, not statistically significant; PD, inpatient day
  2. aMeasure of immediate impact of the intervention; bMeasure of long-term impact of the intervention