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Table 3 Combined diagnostic performance of NASBA, PCR or colloidal gold

From: Application and evaluation of nucleic acid sequence-based amplification, PCR and cryptococcal antigen test for diagnosis of cryptococcosis

Test combination Proven/probable cases (n = 25) Control group (n = 40) Sensitivity (%) Specificity (%) Accuracy (%) Kappa
NASBA+ or PCR+ 23 8 92.00 80.00 84.62 0.69
NASBA+ and PCR+ 16 1 64.00 97.50 84.62 0.65
NASBA+ or colloidal gold+ 25 7 100.00 82.50 89.23 0.78
NASBA+ and colloidal gold+ 23 1 92.00 97.50 95.38 0.90
PCR+ or colloidal gold+ 25 13 100.00 67.50 80.00 0.62
PCR+ and colloidal gold+ 16 1 64.00 97.50 84.62 0.65
NASBA+ or PCR+ or colloidal gold+ 25 14 100.00 65.00 78.46 0.59
NASBA+, PCR+ and colloidal gold+ 16 0 64.00 100.00 86.15 0.69
  1. Best performance values are highlighted in bold