Skip to main content

Table 2 Clinical diagnostic performance of NASBA, PCR and colloidal gold

From: Application and evaluation of nucleic acid sequence-based amplification, PCR and cryptococcal antigen test for diagnosis of cryptococcosis

Parameter

NASBA

PCR

Colloidal gold

Sensitivity [% (95% CI)]

92.00 (72.50–98.60)

64.00 (42.62–81.29)*

100.00 (83.42–100.00)

Specificity [% (95% CI)]

95.00 (81.79–99.13)

80.00 (63.86–90.39)

82.50 (66.64–92.11)

Accuracy [%]

93.85

73.85

89.23

Positive likelihood ratio

18.40 (4.74–71.39)

3.20 (1.61–6.35)

5.71 (2.92–11.20)

Negative likelihood ratio

0.08 (0.02–0.32)

0.45 (0.26–0.77)

0.00 (0.00-NaN)

Positive predictive value [% (95% CI)]

92.00 (72.50–98.60)

66.67 (44.69–83.57)

78.13 (59.56–90.06)

Negative predictive value [% (95% CI)]

95.00 (81.79–99.13)

78.05(61.97–88.89)

100.00 (87.02–100.00)

Youden index

0.87

0.44

0.83

Kappa

0.87

0.44

0.78

  1. Best performance values are highlighted in bold. *P < 0.05 versus NASBA, colloidal gold