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Table 2 Clinical diagnostic performance of NASBA, PCR and colloidal gold

From: Application and evaluation of nucleic acid sequence-based amplification, PCR and cryptococcal antigen test for diagnosis of cryptococcosis

Parameter NASBA PCR Colloidal gold
Sensitivity [% (95% CI)] 92.00 (72.50–98.60) 64.00 (42.62–81.29)* 100.00 (83.42–100.00)
Specificity [% (95% CI)] 95.00 (81.79–99.13) 80.00 (63.86–90.39) 82.50 (66.64–92.11)
Accuracy [%] 93.85 73.85 89.23
Positive likelihood ratio 18.40 (4.74–71.39) 3.20 (1.61–6.35) 5.71 (2.92–11.20)
Negative likelihood ratio 0.08 (0.02–0.32) 0.45 (0.26–0.77) 0.00 (0.00-NaN)
Positive predictive value [% (95% CI)] 92.00 (72.50–98.60) 66.67 (44.69–83.57) 78.13 (59.56–90.06)
Negative predictive value [% (95% CI)] 95.00 (81.79–99.13) 78.05(61.97–88.89) 100.00 (87.02–100.00)
Youden index 0.87 0.44 0.83
Kappa 0.87 0.44 0.78
  1. Best performance values are highlighted in bold. *P < 0.05 versus NASBA, colloidal gold