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Table 2 Odds ratios and predictive values for the presence of group A streptococci or any bacterial finding among patients with a sore throat (n = 220)

From: The aetiology of pharyngotonsillitis in primary health care: a prospective observational study

Clinical findings

Group A streptococci (n = 66)

Any bacteria (n = 103)

OR (95% CI)

aOR, model 1 (95% CI)

PPV (95% CI)

NPV (95% CI)

EPV (95% CI)

OR (95% CI)

aOR, model 1 (95% CI)

PPV (95% CI)

NPV (95% CI)

EPV (95% CI)

No coryza

2.8 (1.5–5.4)††

41 (37–46)

87 (79–92)

97 (88–100)

3.2 (1.8–5.6)†††

58 (52–63)

70 (61–77)

90 (75–97)

No cough

4.4 (2.2–8.8)†††

6.0 (2.5–14)†††

41 (36–46)

86 (79–92)

97 (88–100)

3.1 (1.7–5.4)†††

2.7 (1.4–5.1)††

58 (52–63)

69 (61–77)

90 (74–97)

Temperature ≥ 38.5 °C

2.7 (1.4–5.1)††

1.4 (0.60–3.1)

38 (33–43)

79 (71–86)

96 (86–100)

2.1 (1.2–3.7)††

1.5 (0.76–2.8)

54 (48–59)

61 (53–69)

88 (70–97)

Lymphadenitis

1.7 (0.90–3.1)

1.6 (0.71–3.4)

34 (29–39)

74 (66–81)

96 (83–100)

1.6 (0.93–2.8)

1.2 (0.65–2.3)

51 (45–56)

56 (48–64)

86 (65–96)

Tonsillar coating

3.1 (1.7–5.8)†††

3.5 (1.5–8.0)††

43 (35–51)

76 (70–81)

97 (88–100)

3.0 (1.7–5.4)†††

2.5 (1.3–4.7)††

62 (53–70)

59 (53–64)

92 (77–98)

Palatal petechiae

1.2 (0.48–2.9)

32 (18–51)

68 (66–70)

95 (54–100)

1.4 (0.59–3.1)

52 (34–69)

51 (48–53)

87 (41–98)

Duration ≤ 3 days

1.9 (1.1–3.5)

1.4 (0.65–3.0)

38 (31–45)

74 (68–80)

96 (85–100)

1.9 (1.10–3.3)

1.3 (0.69–2.5)

55 (48–62)

57 (51–63)

89 (69–97)

Age, years

1.09 (1.05–1.13)†††

1.12 (1.07–1.18)†††

1.02 (0.99–1.05)

1.02 (0.99–1.06)

Centor 3–4

4.5 (2.4–8.3)†††

49 (42–57)

82 (77–87)

98 (91–100)

3.6 (2.0–6.4)†††

66 (57–74)

65 (60–70)

94 (81–99)

Centor 3–4 + positive RADT

5.8 (1.4–24)

93 (81–97)

97 (84–100)

Centor 0a

1

13 (3–38)

69 (67–70)

 

1

25 (10–50)

51 (50–53)

 

Centor 1

0.96 (0.17–5.3)

12 (6–23)

65 (62–68)

 

0.95 (0.26–3.5)

24 (15–36)

47 (43–50)

 

Centor 2

2.1 (0.43–10)

23 (16–33)

67 (63–71)

 

2.4 (0.72–8.3)

45 (36–55)

52 (48–57)

 

Centor 3

5.6 (1.2–27)

44 (34–56)

75 (71–78)

 

5.5 (1.6–20)††

65 (53–75)

59 (55–63)

 

Centor 4

9.7 (1.9–50)††

58 (42–73)

75 (72–77)

 

6.3 (1.6–25)††

68 (51–81)

57 (54–59)

 
  1. Crude (univariate) odds ratio (OR) and adjusted ORs (aOR) from the logistic regression are presented with 95% confidence intervals. The multiple model adjusts for the four Centor criteria (no cough, lymphadenitis, fever, and tonsillar coating), age and duration ≤ 3 days. “No coryza” was excluded from the model due to collinearity with “no cough”
  2. PPV positive predictive value (true positives/all positives), NPV negative predictive value (true negatives/all negatives), EPV positive aetiological predictive value, 95% CI 95% confidence interval, RADT rapid antigen detection test
  3. p < 0.05; ††p < 0.01; †††p < 0.001
  4. aOdds ratios for Centor score 1 through 4 are calculated with Centor 0 as reference category