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Table 2 Predictive value of biomarker combinations for neonatal sepsis

From: The potential value of plasma receptor interacting protein 3 in neonates with culture-positive late-onset sepsis

Variable RIP3 + hs-CRP RIP3 + PLT hs-CRP + PLT RIP3 + hs-CRP + PLT
AUC 0.892 0.859 0.842 0.897
Sensitivity 77.8 69.8 65.1 77.8
Specificity 97.5 94.9 94.9 97.5
PPV 96.1 91.7 91.1 96.1
NPV 84.6 79.8 77.3 84.6
PPR 30.72 13.79 12.85 30.72
NPR 0.23 0.32 0.37 0.23
95%CI 0.829–0.938 0.790–0.911 0.772–0.898 0.835–0.942
YI 0.753 0.648 0.600 0.753
  1. AUC area under the curve, CI confidence interval, PPV positive predictive value, NPV negative predictive value, PPR positive probability ratio, NPR negative probability ratio, YI Youden index