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Table 1 Summary of the clinically-confirmed COVID-19 pneumonia patients' characteristics

From: Investigation of SARS-CoV-2 in tear and conjunctival secretions of hospitalized patients with clinically-confirmed COVID-19 pneumonia

Case

Age

Sex

NP RT-PCR (1)

Eye RT-PCR (1)

NP RT-PCR (2)

Eye RT-PCR (2)

Interval

Temperature (1)

Symptoms

Days S-A

History of contacts

Coexisting disorder (chronic medical illness)

Treatments

Temperature (2)

Chest CT lung involvement

Disease severity status

1

45

F

Positive

Negative

Negative

Negative

3

36.4

Dyspnea, hypotension

7

Yes

Focal segmental glomerulosclerosis

HQ

36.2

Bilateral

Moderate

2

22

M

Negative

Negative

Negative

Negative

3

37.3

Cough, dyspnea, fever, headache

7

No

Asthma, migraine

HQ

36.4

Bilateral

Mild

3

66

M

Positive

Negative

Positive

Negative

3

38

Fever, fatigue

4

Yes

Diabetes mellitus, hyperlipidemia

HQ + Favipiravir

36.7

Bilateral

Moderate

4

61

F

Negative

Negative

Negative

Negative

3

36.7

Confusion, dispne

1

Yes

Diabetes mellitus, hypertension, hyperlipidemia, myocardial infarction

HQ + Favipiravir

36.6

Bilateral

Moderate

5

49

M

Negative

Negative

Negative

Negative

2

36

Abdominal pain, vomiting, poor appetite

5

No

Colorectal cancer (liver metastasis, cemoteraphy)

HQ + Antibiotic

36

Bilateral

Moderate

6

84

M

Negative

Negative

Positive

Negative

2

36.7

Chills, vomiting, dyspnea

1

No

No comorbidity

HQ + Antibiotic + Favipiravir

36.6

Bilateral

Severe

7

54

F

Negative

Negative

Negative

Negative

2

36.7

Cough, dyspnea

2

No

Diabetes mellitus, hypertension, chronic kidney failure, heart arrhythmia

HQ + Antibiotic + Favipiravir

36.7

Bilateral

Moderate

8

88

F

Positive

Positive

Positive

Negative

2

36.3

Asymptomatic (positive case detection at home)

0

Yes

Hypertension, coronary artery disease, chronic kidney failure

HQ

36.2

Bilateral

Mild

9

76

F

Positive

Positive

Positive

Negative

2

36.5

Fever, cough, fatigue, dry of throat

5

No

Diabetes mellitus, hypertension

HQ + Antibiotic

36.7

Bilateral

Moderate

10

48

M

Negative

Negative

Negative

Negative

2

36

Speech pelteking, syncope, urinary incontinence

1

No

Cerebrovascular diseases, bladder tumor (newly diagnosed)

HQ + Antibiotic

36.5

Bilateral

Moderate

11

83

F

Negative

Negative

Negative

Negative

2

36.5

Dyspnea, fatigue, foot swelling

5

No

Hypertension, congestive heart failure, coronary artery disease, gut syndrome

HQ + Antibiotic + Favipiravir

36.4

Bilateral

Severe

12

32

F

Negative

Negative

Negative

Negative

2

36

Dyspnea, fatigue, poor appetite, generalized myalgia

7

No

No comorbidity

HQ + Antibiotic

36.5

Bilateral

Moderate

13

52

F

Negative

Negative

Negative

Negative

3

37.5

Chills

1

No

Lung cancer (cemoteraphy)

HQ + Antibiotic

36

Bilateral

Moderate

14

87

M

Negative

Negative

Negative

Negative

3

36.7

Confusion, loss of power and strength in the extremities

0

No

Hypertension, chronic kidney failure, congestive heart failure, heart arrhythmia

HQ + Antibiotic

36

Bilateral

Moderate

15

55

F

Positive

Negative

Positive

Negative

3

36.8

Dyspnea, fever, dry cough

3

No

Diabetes mellitus

HQ + Antibiotic

36.7

Bilateral

Moderate

16

56

M

Positive

Negative

Positive

Negative

3

38

Cough, fever

4

No

No comorbidity

HQ + Antibiotic + Favipiravir

38.3

Bilateral

Moderate

17

35

M

Positive

Positive

Positive

Negative

3

38

Headache, nausea, fever, poor appetite

3

No

No comorbidity

HQ

36.4

Bilateral

Moderate

18

56

M

Negative

Negative

Negative

Negative

3

37.6

Headache, nausea, cough, flank pain, dysuria

4

No

No comorbidity

HQ + Antibiotic

37.3

Unilateral

Moderate

19

70

M

Negative

Negative

Negative

Negative

3

36.6

Cough, back pain

5

Yes

Diabetes mellitus

HQ + Antibiotic

36.2

Bilateral

Moderate

20

31

M

Negative

Negative

Negative

Negative

3

37

Cough, dyspnea, headache, fatigue

3

No

No comorbidity

HQ + Antibiotic

36.2

Bilateral

Mild

21

63

M

Negative

Negative

Negative

Negative

3

36.8

Headache, fever, nausea, abdominal pain

1

No

Coronary artery disease, hypertension

HQ + Antibiotic

36.7

Bilateral

Moderate

22

59

F

Negative

Negative

Negative

Negative

3

36.5

Diarrhea, abdominal pain, nausea, vomiting, fever

3

No

Hypertension, hypothyroidism

HQ

36.7

Bilateral

Moderate

23

87

F

Negative

Negative

Negative

Negative

3

36.5

Dyspnea

3

No

Hypertension

HQ

36.5

Bilateral

Moderate

24

43

F

Positive

Negative

Negative

Negative

3

36.5

Cough, nausea, generalized myalgia, palpitation

4

Yes

Hypertension

HQ + Antibiotic

36.4

Bilateral

Moderate

25

58

M

Positive

Negative

Positive

Negative

3

36.7

Nausea, fatigue

7

Yes

No comorbidity

HQ + Antibiotic

36

Bilateral

Moderate

26

74

M

Positive

Positive

Positive

Negative

3

36.5

Fatigue, confusion poor appetite, self-talk disorder

4

No

Diabetes mellitus, hypertension

HQ + Antibiotic

37.3

Bilateral

Moderate

27

58

F

Positive

Negative

Negative

Negative

3

36.9

Cough, fatigue, back pain

7

Yes

Diabetes mellitus, hypertension

HQ + Antibiotic

36.6

Bilateral

Moderate

28

71

M

Negative

Negative

Negative

Negative

2

36.8

Fatigue, headache, fever

5

No

Rheumatologic disorder

HQ

36

Bilateral

Moderate

29

66

F

Positive

Negative

Negative

Negative

2

37

Cough, fever, nausea, fatigue

7

Yes

Hypothyroidism, heart arrhythmia

HQ + Favipiravir

36.3

Bilateral

Moderate

30

35

M

Positive

Negative

Positive

Negative

2

38.3

Fever, nausea

4

Yes

Bronchiectasis

HQ + Favipiravir

37.6

Bilateral

Moderate

31

65

M

Negative

Negative

Negative

Negative

3

37.2

Sore throat, cough

3

No

Bladder tumor, total thyroidectomy, stomach perforation surgery

HQ + Antibiotic

36.6

Bilateral

Mild

32

46

F

Positive

Negative

Negative

Negative

3

37.7

Fever, cough, dyspnea

7

No

Asthma

HQ

36.5

Bilateral

Moderate

33

63

M

Positive

Negative

Positive

Negative

3

37.9

Fever

5

Yes

Hypertension

HQ

37.1

Bilateral

Moderate

34

72

M

Negative

Negative

Negative

Negative

3

36.5

Fatigue, joint pain, generalized myalgia

7

No

Diabetes mellitus, hypertension, coronary artery disease

HQ

36.3

Bilateral

Mild

35

32

F

Positive

Negative

Negative

Negative

3

36.6

Fever, cough, headache, loss of smell

4

No

No comorbidity

HQ + Antibiotic

37.6

Bilateral

Moderate

36

72

F

Negative

Negative

Negative

Negative

3

37.5

Fever, cough

3

No

Diabetes mellitus, hypertension, asthma, coronary artery disease, hyperlipidemia

HQ

37

Bilateral

Mild

37

58

F

Negative

Negative

Negative

Negative

3

36.5

Chills, myalgia, headache

1

No

No comorbidity

HQ + Antibiotic

36.3

Bilateral

Mild

38

64

M

Negative

Negative

Negative

Negative

3

36.7

Headache, fatigue

2

No

Coronary artery disease (history of cardiac anjio)

HQ

36.4

Bilateral

Moderate

39

58

M

Positive

Positive

Positive

Negative

3

38.9

Fever

3

No

Heart valve disease (heart valve replacement surgery)

HQ

36.2

Bilateral

Mild

40

61

M

Negative

Negative

Negative

Negative

3

36.8

Cough, dizziness, dyspnea, dry of throat, diarrhea

5

No

Coronary artery disease (coronary angioplasty and stenting)

HQ + Antibiotic

36.4

Unilateral

Mild

41

83

F

Positive

Negative

Negative

Negative

3

37.4

Chills, fever

3

No

Coronary artery disease, asthma

HQ + Antibiotic

36.2

Bilateral

Moderate

42

79

F

Negative

Negative

Negative

Negative

3

36.5

Nausea, vomiting, cellulite on the left leg

7

No

Asthma, coronary artery disease, hypertension

HQ + Antibiotic

36

Bilateral

Moderate

43

65

F

Negative

Negative

Negative

Negative

2

36.2

Epistaxis

4

No

Splenectomy, superior mesenteric venous thrombosis

HQ + Antibiotic

36

Bilateral

Moderate

44

42

M

Negative

Negative

Negative

Negative

3

36.5

Chills, fatigue, headache

3

Yes

No comorbidity

HQ

36.3

Bilateral

Mild

45

71

M

Positive

Negative

Positive

Negative

3

38

Cough, fever

10

No

Hypertension, coronary artery disease

HQ + Antibiotic

36.5

Bilateral

Mild

46

64

M

Negative

Negative

Negative

Negative

2

36.5

Abdominal distention, dyspnea, fever, cough

4

No

No comorbidity

HQ

36.9

Bilateral

Mild

47

81

F

Positive

Negative

Positive

Negative

2

36.5

Nausea, vomiting

0

No

Diabetes mellitus

HQ

36.5

Bilateral

Mild

48

42

M

Negative

Negative

Negative

Negative

2

36.7

Fever, cough, dyspnea

1

No

No comorbidity

HQ + Antibiotic

36

Bilateral

Moderate

49

66

M

Negative

Negative

Negative

Negative

2

36.5

Cough, fatigue, vomiting

5

No

No comorbidity

HQ + Antibiotic

36.5

Bilateral

Moderate

50

89

M

Negative

Negative

Negative

Negative

2

36.5

Vomiting, diarrhea

0

No

Lung cancer, chronic obstructive pulmonary disease, Alzheimer's disease

HQ + Antibiotic

36.4

Bilateral

Moderate

51

73

F

Positive

Negative

Positive

Negative

3

36.5

Fatigue, loss of taste

7

No

Diabetes mellitus, hypertension,coronary artery disease

HQ

36

Bilateral

Mild

52

62

F

Positive

Negative

Positive

Negative

3

37.2

Fever, sore throat

2

No

No comorbidity

HQ + Antibiotic

36

Unilateral

Mild

53

86

F

Positive

Negative

Negative

Negative

3

36.6

Dyspnea

3

No

Congestive heart failure, coronary artery disease,hypertension, chronic kidney failure

HQ + Antibiotic + Favipiravir

36.2

Bilateral

Moderate

54

48

F

Negative

Negative

Negative

Negative

3

36.2

Chest pain, dyspnea

1

No

Pulmonary embolism

HQ + Antibiotic

36.4

Bilateral

Moderate

55

47

M

Positive

Negative

Negative

Negative

3

36.5

Headache, hypotension

2

No

Hypertension, hypothyroidism

HQ + Antibiotic

36.3

Bilateral

Moderate

56

76

F

Negative

Negative

Negative

Negative

3

36.6

Dyspnea, fever, abdominal pain

1

No

Coronary artery disease

HQ

36.3

Bilateral

Mild

57

70

M

Negative

Negative

Negative

Negative

3

36

Chest pain

0

No

Diabetes mellitus, coronary artery disease, chronic kidney failure

HQ

36.7

Bilateral

Mild

58

77

M

Negative

Negative

Negative

Negative

3

39.8

Fever, dyspnea, vomiting

1

No

Coronary artery disease (heart bypass surgery)

HQ + Antibiotic + Favipiravir

36.1

Bilateral

Severe

59

65

F

Negative

Negative

Negative

Negative

3

36.5

Cough, chills

4

No

No comorbidity

HQ + Antibiotic

36.6

Bilateral

Mild

60

59

M

Negative

Negative

Negative

Negative

2

36

Dyspnea

2

No

Coronary artery disease

HQ + Antibiotic

36

Bilateral

Moderate

61

73

M

Negative

Negative

Negative

Negative

3

36.9

Cough, dyspnea, legs swelling, chest pain

2

No

Hypertension, coronary artery disease (heart bypass surgery)

HQ

37.1

Bilateral

Moderate

62

43

M

Negative

Negative

Negative

Negative

3

37.1

Fever, headache, diarrhea, nausea, dry of throat

2

Yes

No comorbidity

HQ

36

Bilateral

Moderate

63

50

F

Negative

Negative

Negative

Negative

3

37.3

Fatigue, cough, fever, dyspnea

5

No

No comorbidity

HQ + Antibiotic + Favipiravir

36.3

Bilateral

Severe

64

59

M

Negative

Negative

Negative

Negative

3

36

Dyspnea

3

No

Distal Pankreatektomi ve splenektomi (pancreatic cancer?)

HQ

36.6

Bilateral

Moderate

65

78

F

Negative

Negative

Negative

Negative

3

36.2

Abdominal pain

10

No

Coronary artery disease

HQ + Antibiotic

36

Bilateral

Mild

66

86

F

Negative

Negative

Negative

Negative

3

36.4

Dyspnea

1

No

Heart failure, coronary artery disease, myocardial infarction

HQ + Favipiravir

36

Bilateral

Moderate

67

71

M

Positive

Negative

Positive

Negative

3

36.3

Cough, dyspnea

7

Yes

Hypertension, coronary artery disease

HQ + Favipiravir

36.3

Unilateral

Moderate

68

71

F

Positive

Negative

Negative

Negative

3

36.5

Cough, fatigue, headache

7

Yes

Goitre

HQ + Antibiotic

36.3

Bilateral

Mild

69

83

F

Negative

Negative

Negative

Negative

3

36

Cough expectorate, fatigue

10

No

Diabetes mellitus, hypertension, coronary artery disease, chronic bronchitis

HQ + Antibiotic

36.8

Bilateral

Moderate

70

30

F

Negative

Negative

Positive

Negative

3

37.5

Cough, fatigue

7

No

No comorbidity

HQ + Antibiotic

36.2

Bilateral

Moderate

71

77

M

Negative

Negative

Negative

Negative

3

36.5

Dizziness, weakness of the right side

0

No

Diabetes mellitus, cerebrovascular diseases

HQ

36.3

Unilateral

Mild

72

70

F

Negative

Negative

Negative

Negative

3

36

Dyspnea, cough

1

No

Coronary artery disease, hypertension, asthma, diabetes mellitus

HQ + Antibiotic

35.5

Bilateral

Moderate

73

86

M

Negative

Negative

Negative

Negative

3

37.3

fever, chills, dyspnea

3

No

Coronary artery disease, hypertension, diabetes mellitus, chronic kidney failure

HQ + Antibiotic

36.7

Bilateral

Moderate

74

61

M

Negative

Negative

Negative

Negative

3

36

Chills, generalized myalgia, cough

1

No

No comorbidity

HQ + Antibiotic

36

Bilateral

Moderate

75

56

F

Negative

Negative

Negative

Negative

3

36

Fatigue, myalgia, back pain

3

No

Coronary artery disease, hypertension

HQ

36.3

Bilateral

Mild

76

65

M

Negative

Negative

Negative

Negative

3

36.1

Sudden shortness of breath, disartria, dizziness, sweating

0

No

Diabetes mellitus, hypertension

HQ

36.4

Bilateral

Moderate

77

52

M

Positive

Negative

Positive

Negative

3

36.1

Dry cough

3

No

Diabetes mellitus

HQ + Antibiotic + Favipiravir

36.4

Bilateral

Moderate

78

64

F

Positive

Negative

Negative

Negative

3

36.6

cough, dyspnea, fatigue

7

No

Diabetes mellitus, hypertension

HQ

36.5

Bilateral

Moderate

79

70

M

Negative

Negative

Negative

Negative

3

36.6

Cough, hemoptysis

0

No

Coronary artery disease, cerebrovascular diseases

HQ

36.5

Bilateral

Mild

80

63

F

Positive

Negative

Negative

Negative

3

36.5

Fatigue, palpitation

4

No

Diabetes mellitus

HQ + Favipiravir

36.2

Bilateral

Severe

81

46

M

Positive

Negative

Negative

Negative

3

36.3

Cough, dyspnea, fatigue, sweating

7

Yes

No comorbidity

HQ

36.6

Bilateral

Moderate

82

55

M

Positive

Negative

Negative

Negative

3

36.2

Cough, dyspnea, chills

4

No

Cerebrovascular diseases, diabetes mellitus, coronary artery disease (bypass surgery)

HQ + Antibiotic

36

Bilateral

Mild

83

27

M

Negative

Negative

Negative

Negative

3

36.8

Cough, fever

3

No

No comorbidity

HQ + Antibiotic

36.6

Unilateral

Moderate

  1. NP nasopharyngeal, Eye: tear and conjunctival secretions, RT-PCR reverse transcription polymerase chain reaction, Days S-A days from onset of symptoms to admission