Fig. 2

Autopsy results. A SARS-CoV-2 RNA copies in each organ system measured as log10 /10.000 cells. B–D Histopathology of the lung: areas of pneumonic congestion without any further destruction of the lung parenchyma (B PAS reaction, C, D H&E stain). E–G: SARS-CoV-2 in-situ-hybridization of the lung: specific reaction in pulmonary macrophages (E) and pneumocytes (F, G). H–J Histopathology of the liver: subtotal liver cirrhosis with moderate portal inflammatory infiltrates and proliferating bile ducts (H, arrow), areas of acute liver cell necrosis (I, asterisk) and cholestasis (J, arrow). K–M Immunohistochemistry of the liver: strong reactivity of bile duct epithelium for antibodies against ACE2 (K), Cathepsin L (L) and TMPRSS2 (M). N–P SARS-CoV-2 in-situ-hybridization of the liver: strong cytoplasmatic signals in the bile duct epithelium (arrows)