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Table 3 In vitro antifungal susceptibility of 1844 clinical isolates of Candida species as determined by the CLSI method

From: Correction to: Molecular identification and antifungal susceptibility profile of yeast from vulvovaginal candidiasis

Candida species (n) Antifungal agents
  BUC CLO FLC ITC MIC TEC VRC
C. lusitaniae, n = 1 Range 0.03 0.03 0.125 0.03 0.03 0.03 0.03
C. Fabianii, n = 3 Range 0.03–0.25 0.03–0.06 0.5–1 0.03–0.25 0.125–1 0.03 0.03
MIC50 0.125 0.03 0.5 0.06 0.125 0.03 0.03
MIC90 0.25 0.06 1 0.25 1 0.03 0.03
Trichosporon asahii, n = 1 Range 0.03 0.03 0.25 0.03 0.06 0.03 0.03
Rhodotorula, n = 3 Range 0.03–0.5 0.03–1 4–128 0.03–8 0.25–8 0.03–0.5 0.03–1
MIC50 0.06 0.06 64 2 1 0.06 0.03
MIC90 0.5 1 128 8 8 0.5 1
Kodamaea ohmeri, n = 2 Range 0.125–0.5 0.03 0.25–2 0.125–0.25 0.25–0.5 0.03 0.03
MIC50 0.125 0.03 0.25 0.125 0.25 0.03 0.03
MIC90 0.5 0.03 2 0.25 0.5 0.03 0.03
Issatchenkia terricola, n = 2 Range 1–4 0.06–0.125 32–64 0.25–0.5 0.5 0.25 0.25
MIC50 1 0.06 32 0.25 0.5 0.25 0.25
MIC90 4 0.125 64 0.5 0.5 0.25 0.25
Torulaspora pretoriensis, n = 1 Range 0.25 0.03 8 0.5 0.5 0.125 0.125
ATCC90028* Range 0.015–0.5 0.015–0.5 0.125–2 0.015–4 0.008–0.015 0.015–32 0.015–8
GM 0.04 0.03 0.21 0.08 0.06 0.03 0.03
MIC90 0.125 0.03 0.5 0.25 0.015 0.03 0.03
Candida species (n) Antifungal agents
   AmB FLU NYS TEB AFG CFG MFG
C. albicans
n = 1272
Range 0.015–32 0.03–128 0.03–32 0.03–256 0.008–0.5 0.008–0.5 0.008–0.5
  GM 0.22 0.70 1.60 45.11 0.015 0.1 0.03
  MIC90 0.5 4 8 256 0.03 0.25 0.25
  R   3.3%    0 0 0
C. africana
n = 49
Range 0.03–32 0.06–8 0.125–4 0.25–256 0.008–0.03 0.015–0.5 0.008–0.5
  GM 0.08 0.68 0.5 17.31 0.01 0.06 0.02
  MIC90 1 2 4 128 0.015 0.25 0.06
C. dubliniensis
n = 1
Range 0.06 0.06 0.25 16 0.008 0.015 0.008
C. glabrata
n = 267
Range 0.03–2 0.06–16 0.03–32 0.25–256 0.008–0.5 0.008–0.5 0.008–0.5
  GM 0.29 0.18 3.39 26.62 0.03 0.11 0.05
  MIC90 1 1 8 256 0.06 0.25 0.25
  R   0    0 0 0
C. nivariensis
n = 9
Range 0.06–2 0.125–4 0.5–4 1–256 0.015–0.06 0.08–0.5 0.015–0.5
  MIC50 0.06 0.5 1 128 0.06 0.25 0.015
  MIC90 2 2 4 256 0.06 0.5 0.5
C. bracarensis
n = 2
Range 0.06–1 0.125–2 0.25–8 8–256 0.015–0.03 0.125–0.5 0.015–0.5
  MIC50 0.06 0.125 0.25 8 0.015 0.125 0.015
  MIC90 1 2 8 256 0.03 0.5 0.5
C. parapsilosis
n = 76
Range 0.03–2 0.125–8 0.03–32 0.25–256 0.008–1 0.008–1 0.008–1
  GM 0.19 0.14 0.59 0.62 0.69 0.60 0.54
  MIC90 1 0.125 4 32 0.5 0.5 0.5
  R   0    5.2% 5.2% 1.3%
C. metapsilosis
n = 20
Range 0.015–0.5 0.125–4 0.06–4 0.25–256 0.015–0.5 0.008–0.5 0.015–1
  GM 0.10 0.177 0.46 2.17 0.17 0.17 0.39
  MIC90 0.5 1 4 256 0.25 0.25 0.5
Candida species (n) Antifungal agents
   AmB FLU NYS TEB AFG CFG MFG
C. orthopsilosis
n = 6
Range 0.06–0.25 0.125–2 0.06–8 0.25–128 0.008–1 0.015–1 0.008–0.5
  MIC50 0.125 1 0.5 64 0.08 0.30 0.25
  MIC90 0.25 2 8 128 1 1 0.5
C. tropicalis
n = 61
Range 0.03–1 0.125–32 0.03–8 0.25–256 0.015–0.125 0.008–0.5 0.008–0.5
  GM 0.19 0.23 0.54 60.02 0.03 0.24 0.04
  MIC90 0.5 1 4 256 0.06 0.5 0.5
  R   1.8%    0 0 0
C. krusei
n = 54
Range 0.03–1 0.125–32 0.03–4 16–256 0.015–0.5 0.008–1 0.008–0.5
  GM 0.43 4.2 0.32 75.66 0.08 0.08 0.15
  MIC90 1 16 1 256 0.125 0.5 0.25
  R   2.9%    0 1.85% 0
Saccharomyces cerevisiae
n = 12
Range 0.03–4 0.06–8 0.125–32 0.25–256 0.015–0.5 0.08–0.5 0.015–0.5
  GM 0.18 0.21 0.78 53.20 0.14 0.10 0.18
  MIC90 1 1 8 256 0.5 0.25 0.25
C. guilliermondii
n = 2
Range 0.06–0.5 0.125–0.25 0.25–0.5 64–128 0.015–0.25 0.25–0.5 0.015–0.25
  MIC50 0.06 0.125 0.25 64 0.015 0.25 0.015
  MIC90 0.5 0.25 0.5 128 0.25 0.5 0.25
  R   0    0 0 0
C. lusitaniae
n = 1
Range 0.125 0.125 0.25 0.25 0.03 0.25 0.015
C. fabianii
n = 3
Range 0.06–0.25 0.125 0.25 128 0.015–0.03 0.015–0.25 0.015–0.06
  MIC50 0.06 0.125 0.25 128 0.015 0.015 0.03
  MIC90 0.25 0.125 0.25 128 0.03 0.25 0.06
Trichosporon asahii
n = 1
Range 0.125 1 0.25 128 0.015 0.5 0.015
Rhodotorula
n = 3
Range 0.03–0.5 0.125 0.06–0.125 8–256 0.06–0.5 0.25–0.5 0.25–0.5
  MIC50 0.03 0.125 0.06 8 0.06 0.25 0.25
  MIC90 0.5 0.125 0.125 256 0.5 0.5 0.5
Kodamaea ohmeri
n = 2
Range 0.125–1 0.125 0.5 128 0.015 0.125–0.25 0.015–0.03
  MIC50 0.125 0.125 0.5 128 0.015 0.125 0.015
  MIC90 1 0.125 0.5 128 0.015 0.25 0.03
Issatchenkia terricola
n = 2
Range 0.125–0.5 8 0.5 128–256 0.06 0.06 0.08
  MIC50 0.125 8 0.5 128 0.06 0.06 0.08
  MIC90 0.5 8 0.5 256 0.06 0.06 0.08
Torulaspora pretoriensis
n = 1
Range 0.125 0.125 0.25 16 0.015 0.125 0.015
ATCC90028a Range 0.03–2 0.125–8 0.25–16 1–256 0.008–0.015 0.015–0.5 0.008–0.015
  GM 0.22 0.64 1.31 88.22 0.01 0.09 0.01
  MIC90 1 2 8 256 0.015 0.5 0.015
  1. GM geometry mean, BUC butoconazole, CLO Clotrimazole, FLC Fluconazole, ITC Itraconazole, VRC Voriconazole, MIC Miconazole, TEC Terconazole, AmB Amphotericin B, FLU Flucytosine, NYS Nystatin, TEB Terbinafine, AFG Anidulafungin, CFG Caspofungin, MFG Micafungin
  2. aATCC90028 was tested 57 times