Table 2 PON1 polymorphic variants and spontaneous HCV clearance in HD individuals
Genotypes and alleles | Anti-HCV positive and HCV RNA negative | Anti-HCV and HCV RNA positive | Odds ratio (95% CI), P-valuea |
|---|---|---|---|
PON1 rs662 n = 175, P-value for HWE = 0.295 | |||
AA | 37 (48.7%) | 60 (60.6%) | Reference |
AG | 32 (42.1%) | 38 (38.4%) | 0.344 |
GG | 7 (9.2%) | 1 (1.0%) | 0.009 |
Allele A | 106 (69.7%) | 158 (79.8%) | Reference |
Allele G | 46 (30.3%) | 40 (20.2%) | 0.034 |
PON1 rs854560 n = 180, P-value for HWE = 0.440 | |||
AA | 31 (37.8%) | 35 (35.7%) | Reference |
AT | 33 (40.2%) | 57 (58.2%) | 0.249 |
TT | 18 (22%) | 6 (6.1%) | 0.030 |
Allele A | 95 (57.9%) | 127 (64.8%) | Reference |
Allele T | 69 (42.1%) | 69 (35.2%) | 0.193 |
PON1 rs705379, n = 178, P-value for HWE = 0.582 | |||
CC | 21 (26.6%) | 20 (20.2%) | Reference |
CT | 33 (41.8%) | 52 (52.5%) | 0.249 |
TT | 25 (31.6%) | 27 (27.3%) | 0.836 |
Allele C | 75 (47.5%) | 92 (46.5%) | Reference |
Allele T | 83 (52.5%) | 106 (53.5%) | 0.915 |