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Table 1 Demographic and clinical characteristics of patients by COVID-19 disease progressiona

From: Assessment of COVID-19 progression on day 5 from symptoms onset

 

TOT (n = 235)

Disease progressiona

Univariate

 

No (n = 147)

Yes (n = 88)

OR (95% CI)

p-value

Age (years) > 65

157 (67%)

90 (61%)

67 (76%)

2.02 (1.12 to 3.65)

0.020

Gender (female)

87 (37%)

58 (40%)

29 (33%)

0.75 (0.43 to 1.31)

0.318

Comorbidities (any)

190 (81%)

119 (81%)

71 (81%)

0.98 (0.50 to 1.92)

0.959

 Diabetes

40/190 (21%)

27/119 (23%)

13/71 (18%)

0.76 (0.37 to 1.59)

0.475

 Cancer

33/190 (17%)

22/119 (19%)

11/71 (16%)

0.81 (0.37 to 1.79)

0.599

 Cardiovascular diseases

90/190 (47%)

45/119 (38%)

45/71 (63%)

2.85 (1.55 to 5.23)

0.001

 Renal diseases

39/190 (21%)

20/119 (17%)

19/71 (27%)

0.81 (0.89 to 3.69)

0.103

 Respiratory diseases

34/190 (18%)

21/119 (18%)

13/71 (18%)

1.05 (0.49 to 2.25)

0.908

 Liver diseases

6/190 (3%)

4/119 (3%)

2/71 (3%)

0.83 (0.15 to 4.67)

0.836

 BMI > 30

16/190 (8%)

12/119 (10%)

4/71 (6%)

0.53 (0.17 to 1.72)

0.292

 Neurologic/Psychiatric diseases

66/190 (35%)

38/119 (32%)

28/71 (39%)

1.39 (0.75 to 2.56)

0.294

Symptoms

 Fever

193 (82%)

120 (82%)

73 (83%)

1.09 (0.55 to 2.19)

0.798

 Cough

106 (45%)

68 (46%)

38 (43%)

0.88 (0.52 to 1.50)

0.646

 Dyspnoea

87 (37%)

41 (28%)

46 (52%)

2.83 (1.63 to 4.92)

0.000

Treatment

 Steroids (at least 5 days)

38/183 (21%)

26/124 (21%)

12/59 (20%)

0.96 (0.45 to 2.07)

0.922

 Non-invasive ventilation

26 (11%)

17 (12%)

9 (10%)

0.87 (0.37 to 2.05)

0.752

 Invasive mechanical ventilation

30 (13%)

2 (1%)

28 (32%)

33.83 (7.81 to 156.53)

0.000

Outcomes (days), mean (SD)

 Time from symptoms onset to admission

3.6 (3.2)

3.2 (2.4)

4.0 (3.9)

0.78 (− 0.08 to 1.63)

0.076

 Length hospital stay

13.2 (11.5)

12.4 (11.2)

14.3 (12)

1.82 (− 1.24 to 4.87)

0.243

  1. BMI: body mass index
  2. aDisease progression is a composite outcome defined as: death and/or transfer to ICU within day-11 after symptom onset and/or PaO2/FiO2 ratio < 200 on day 10 after symptom onset. Results are presented as mean (SD) and mean difference (95% CI) or frequencies (%) and OD (95% CI) as appropriate