Table 1 Baseline characteristics of 123 patients with SARS-Cov-2 infection
Standard care (n = 12) | Interferon (n = 44) | LPV/r plus interferon (n = 67) | Total patients (n = 123) | P-value | |
|---|---|---|---|---|---|
Male | 4 (33.33) | 23 (52.27) | 35 (52.24) | 62 (50.41) | 0.46 |
Age (years) | 59.50 (37, 66.25) | 42.50 (30.75, 58.50) | 40.00 (32.00, 51.00) | 41.00 (32.00, 57.00) | 0.05 |
Comorbidities | 6 (50) | 22 (50) | 27 (40.30) | 55 (44.72) | 0.56 |
Diabetes | 0 | 2 (4.55) | 2 (2.99) | 4 (3.25) | |
Hypertension | 2 (16.67) | 7 (15.91) | 10 (14.93) | 19 (15.45) | |
Cardiovascular disease | 0 | 1 (2.27) | 1 (1.49) | 2 (1.63) | |
Hyperlipemia | 1 (8.33) | 1 (2.27) | 1 (1.49) | 3 (2.44) | |
Cerebrovascular disease | 0 | 2 (4.55) | 3 (4.48) | 5 (4.07) | |
Previous surgery | 1 (8.33) | 5 (11.36) | 7 (10.45) | 13 (10.6) | |
Other disease | 2 (16.67) | 4 (9.09) | 3 (4.48) | 9 (7.32) | |
Fever | 9 (75) | 35 (79.50) | 58 (86.57) | 102 (82.93) | 0.47 |
Body temperature (°C) | 37.10 (36.50, 37.95) | 36.80 (36.60, 37.25) | 37.20 (36.50, 37.70) | 37.00 (36.50, 37.60) | 0.34 |
Severity category at admission | 0.15 | ||||
Mild | 8 (66.67) | 38 (86.36) | 59 (88.06) | 105 (85.37) | |
Severe | 4 (33.33) | 6 (13.64) | 8 (11.94) | 18 (14.63) | |
Time from symptoms onset to hospitalization | 4 (2, 8) | 5 (2, 7) | 5 (2, 8) | 5 (2, 7) | 0.98 |
Time from symptoms onset to treatment | 6 (3, 10) | 5 (3, 8) | 5 (3, 8) | 0.86 | |
Duration of treatment | 7 (3, 19) | 11 (6, 18) | 10 (5, 18) | 0.05 | |
Oxygen therapy | 6 (50) | 22 (50) | 26 (38.81) | 54 (43.90) | 0.46 |
Low flow oxygen | 4 (33.33) | 20 (45.45) | 25 (37.31) | 49 (39.84) | |
High flow oxygen | 2 (16.67) | 2 (4.55) | 1 (1.49) | 5 (4.07) | |
White-cell count (× 109/L) | 4.49 (3.31, 6.09) | 4.39 (3.50, 5.66) | 4.89 (4.07, 5.84) | 4.66 (3.75, 5.76) | 0.40 |
Neutrophil count (× 109/L) | 2.84 (2.07, 4.66) | 2.75 (2.04, 3.79) | 3.26 (2.30, 4.14) | 3.05 (2.17, 3.85) | 0.67 |
Lymphocyte count (× 109/L) | 1.19 (0.83, 1.44) | 1.17 (0.85, 1.37) | 1.19 (0.95, 1.72) | 1.19 (0.93, 1.53) | 0.47 |
Monocyte count (× 109/L) | 0.30 (0.21, 0.43) | 0.30 (0.22, 0.41) | 0.36 (0.25, 0.43) | 0.33 (0.24, 0.42) | 0.36 |
Platelet count (× 109/L) | 181.50 (170.50, 239.75) | 174.00 (134.00, 250.00) | 203.00 (151.00, 239.00) | 190.00 (150.00, 244.00) | 0.60 |
CRP (mg/L) | 13.65 (1.15, 36.88) | 8.05 (1.10, 26.80) | 11.40 (1.40, 31.90) | 10.20 (1.20, 31.40) | 0.90 |
Serum creatinine (μmol/L) | 56.15 (48.30, 79.93) | 68.70 (57.48, 73.75) | 68.50 (56.30, 79.70) | 68.50 (55.80,78.50) | 0.28 |
Aspartate aminotransferase (U/L) | 23.00 (11.90, 32.50) | 24.30 (18.40, 34.00) | 24.50 (17.08, 32.00) | 24.30 (17.83, 32.13) | 0.75 |
Alanine aminotransferase (U/L) | 27.90 (17.95, 37.48) | 23.10 (14.90, 34.70) | 24.00 (17.60, 32.20) | 24.00 (17.10, 32.78) | 0.79 |
TBIL (U/L) | 9.40 (6.90, 14.00) | 10.60 (7.90, 13.70) | 10.00 (8.05, 14.70) | 10.40 (7.80, 14.00) | 0.56 |
LDH (U/L) | 214.40 (193.30, 314.70) | 202.55 (179.90, 266.50) | 220.30 (185.70, 301.40) | 214.35 (183.55, 297.58) | 0.49 |
Creatine kinase (U/L) | 59.90 (32.23, 120.00) | 67.80 (42.33, 121.13) | 78.20 (57.60, 132.80) | 70.00 (50.00, 132.20) | 0.13 |