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Table 1 Baseline characteristics of 123 patients with SARS-Cov-2 infection

From: Comparative therapeutic efficacy of interferon alfa-2b and combination lopinavir/ritonavir plus interferon alfa-2b against SARS-CoV-2

  Standard care (n = 12) Interferon (n = 44) LPV/r plus interferon (n = 67) Total patients (n = 123) P-value
Male 4 (33.33) 23 (52.27) 35 (52.24) 62 (50.41) 0.46
Age (years) 59.50 (37, 66.25) 42.50 (30.75, 58.50) 40.00 (32.00, 51.00) 41.00 (32.00, 57.00) 0.05
Comorbidities 6 (50) 22 (50) 27 (40.30) 55 (44.72) 0.56
 Diabetes 0 2 (4.55) 2 (2.99) 4 (3.25)  
 Hypertension 2 (16.67) 7 (15.91) 10 (14.93) 19 (15.45)  
 Cardiovascular disease 0 1 (2.27) 1 (1.49) 2 (1.63)  
 Hyperlipemia 1 (8.33) 1 (2.27) 1 (1.49) 3 (2.44)  
 Cerebrovascular disease 0 2 (4.55) 3 (4.48) 5 (4.07)  
 Previous surgery 1 (8.33) 5 (11.36) 7 (10.45) 13 (10.6)  
 Other disease 2 (16.67) 4 (9.09) 3 (4.48) 9 (7.32)  
Fever 9 (75) 35 (79.50) 58 (86.57) 102 (82.93) 0.47
Body temperature (°C) 37.10 (36.50, 37.95) 36.80 (36.60, 37.25) 37.20 (36.50, 37.70) 37.00 (36.50, 37.60) 0.34
Severity category at admission 0.15
 Mild 8 (66.67) 38 (86.36) 59 (88.06) 105 (85.37)  
 Severe 4 (33.33) 6 (13.64) 8 (11.94) 18 (14.63)  
Time from symptoms onset to hospitalization 4 (2, 8) 5 (2, 7) 5 (2, 8) 5 (2, 7) 0.98
Time from symptoms onset to treatment   6 (3, 10) 5 (3, 8) 5 (3, 8) 0.86
Duration of treatment   7 (3, 19) 11 (6, 18) 10 (5, 18) 0.05
Oxygen therapy 6 (50) 22 (50) 26 (38.81) 54 (43.90) 0.46
 Low flow oxygen 4 (33.33) 20 (45.45) 25 (37.31) 49 (39.84)  
 High flow oxygen 2 (16.67) 2 (4.55) 1 (1.49) 5 (4.07)  
White-cell count (× 109/L) 4.49 (3.31, 6.09) 4.39 (3.50, 5.66) 4.89 (4.07, 5.84) 4.66 (3.75, 5.76) 0.40
Neutrophil count (× 109/L) 2.84 (2.07, 4.66) 2.75 (2.04, 3.79) 3.26 (2.30, 4.14) 3.05 (2.17, 3.85) 0.67
Lymphocyte count (× 109/L) 1.19 (0.83, 1.44) 1.17 (0.85, 1.37) 1.19 (0.95, 1.72) 1.19 (0.93, 1.53) 0.47
Monocyte count (× 109/L) 0.30 (0.21, 0.43) 0.30 (0.22, 0.41) 0.36 (0.25, 0.43) 0.33 (0.24, 0.42) 0.36
Platelet count (× 109/L) 181.50 (170.50, 239.75) 174.00 (134.00, 250.00) 203.00 (151.00, 239.00) 190.00 (150.00, 244.00) 0.60
CRP (mg/L) 13.65 (1.15, 36.88) 8.05 (1.10, 26.80) 11.40 (1.40, 31.90) 10.20 (1.20, 31.40) 0.90
Serum creatinine (μmol/L) 56.15 (48.30, 79.93) 68.70 (57.48, 73.75) 68.50 (56.30, 79.70) 68.50 (55.80,78.50) 0.28
Aspartate aminotransferase (U/L) 23.00 (11.90, 32.50) 24.30 (18.40, 34.00) 24.50 (17.08, 32.00) 24.30 (17.83, 32.13) 0.75
Alanine aminotransferase (U/L) 27.90 (17.95, 37.48) 23.10 (14.90, 34.70) 24.00 (17.60, 32.20) 24.00 (17.10, 32.78) 0.79
TBIL (U/L) 9.40 (6.90, 14.00) 10.60 (7.90, 13.70) 10.00 (8.05, 14.70) 10.40 (7.80, 14.00) 0.56
LDH (U/L) 214.40 (193.30, 314.70) 202.55 (179.90, 266.50) 220.30 (185.70, 301.40) 214.35 (183.55, 297.58) 0.49
Creatine kinase (U/L) 59.90 (32.23, 120.00) 67.80 (42.33, 121.13) 78.20 (57.60, 132.80) 70.00 (50.00, 132.20) 0.13
  1. Data are median (IQR), n (%)
  2. CRP C-reactive protein, LDH lactate dehydrogenase, TBIL total bilirubin