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Table 1 Univariate logistic regression analysis to identify factors associated with molecular clusters, i.e. as a surrogate for recent transmission

From: Transmission patterns of rifampicin resistant Mycobacterium tuberculosis complex strains in Cameroon: a genomic epidemiological study

 

Ungrouped (n = 110)

%

Clustered (n = 85)

%

Univariate logistic regression

OR

95% lower

95% upper

P value

Age

        

  > 50

18

16.4

6

7.1

REF

   

 30–50

51

46.4

44

51.8

2.6

0.9

7.1

0.06

  < 30

34

30.9

30

35.3

2.6

0.9

7.5

0.07

 Unknown

7

6.4

5

5.9

2.1

0.5

9.4

0.31

Gender

        

 Female

41

37.3

37

43.5

REF

   

 Male

66

60

46

54.1

0.8

0.4

1.4

0.39

 Unknown

3

2.7

2

2.4

0.7

0.1

4.7

0.75

HIV status

        

 Negative

50

45.5

51

60

REF

   

 Positive

33

30

20

23.5

0.6

0.3

1.2

0.13

 Unknown

27

24.5

14

16.5

0.5

0.2

1.1

0.08

Lineage

        

 Others

7

6.4

10

11.8

REF

   

 L4.X

49

44.5

26

30.6

0.4

0.1

1.1

0.07

 L4.6

54

49.1

49

57.6

0.6

0.2

1.8

0.39

Genotypic resistances (n)

1.7 (mean)

 

2.4 (mean)

 

1.7

1.3

2.3

6.64E−05

(per unit increase)

Compensatory mutation

        

 No

85

77.3

53

62.4

REF

   

 Yes

25

22.7

32

37.6

2.1

1.1

3.8

0.02

High dose isoniazid

        

 Susceptible

39

35.5

5

5.9

REF

   

 Resistant

71

64.5

80

94.1

8.8

3.3

23.5

1.53E−05

Ethambutol

        

 Susceptible

62

56.4

22

25.9

REF

   

 Resistant

48

43.6

63

74.1

3.7

2

6.8

3.02E−05

Pyrazinamide

        

 Susceptible

70

63.6

41

48.2

REF

   

 Resistant

40

36.4

44

51.8

1.8

1.1

3.3

0.03

Prothionamide

        

 Susceptible

87

79.1

69

81.2

REF

   

 Resistant

23

20.9

16

18.8

0.9

0.4

1.8

0.72

  1. P-values < 0.05 indicated in bold text
  2. Factors with P ≤ 0.1 were included in backwards exclusion/forward selection procedures to obtain the best supported multiple logistic regression model, which results are reported in the main text only
  3. OR odds ratio