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Table 4 Dynamic changes in liver function test parameters in 13 COVID-19 patients with chronic liver disease

From: Dynamic changes in liver function parameters in patients with coronavirus disease 2019: a multicentre, retrospective study

  Day − 3 to − 7 Day 1 Day 5a Day 10b Viral clearancec
ALT (0–40 U/L) 22 (19–76) 21 (15.5–67.5) 23.5 (14.8–73.8) 24 (11.5–54.5) 21.5 (17–28.3)
 > 40 U/L 5 (38.5) 4 (30.8) 3/12 (25) 2/8 (25) 1/12 (8.3)
AST (0–40 U/L) 32 (20.5–45) 32 (23–39.5) 23 (17–34.8) 27 (15–41.3) 25 (14.8–30.8)
 > 40 U/L 4 (30.8) 3 (23.1) 2/12 (16.7) 2/8 (25) 1/12 (8.3)
GGT (0–58 U/L) 50 (29–121) 61 (37–132) 42.5 (28.3–103) 78 (33–182.8) 50 (30–93.5)
 > 58 U/L 4 (30.8) 7 (53.8) 4/12 (33.3) 5/8 (62.5) 4/12 (33.3)
ALP (40–130 U/L) 66 (57.5–69.5) 63 (54.5–81) 63 (46.3–85.5) 65.5 (37.5–75.8) 63 (52–70.5)
 > 130 U/L 1 (7.7) 0 (0) 1/12 (8.3) 0/8 (0) 0/12 (0)
ALB (35–55 g/L) 35.1 (33.5–41.5) 34 (30–40.5) 32.8 (31.2–37.6) 36.7 (32.4–37.9) 33.2 (31.5–36.3)
 < 35 g/L 5 (38.5) 8 (61.5) 6/12 (50) 3/8 (37.5) 7/12 (58.3)
TBIL (0–25 μmol/L) 15 (10.2–19.4) 10.4 (9.6–20.3) 12.5 (6.8–24.4) 8.5 (5.3–20.5) 10.7 (8.1–16.9)
 > 25 μmol/L 0 (0) 0 (0) 3/12 (25) 1/8 (12.5) 0/12 (0)
  1. Data are presented as median (interquartile range), n (%), or n/N (%), where N is the total number of cases with available data
  2. aData were unavailable in 1 patient because viral shedding discontinuation occurred on day 4
  3. bData were unavailable in 5 patients because viral shedding discontinuation occurred before day 10
  4. cData were unavailable in 1 patient because he did not clear the virus until death. The corresponding normal ranges and units of the liver function test parameters are presented in parentheses