Table 4 Dynamic changes in liver function test parameters in 13 COVID-19 patients with chronic liver disease
Day − 3 to − 7 | Day 1 | Day 5a | Day 10b | Viral clearancec | |
|---|---|---|---|---|---|
ALT (0–40 U/L) | 22 (19–76) | 21 (15.5–67.5) | 23.5 (14.8–73.8) | 24 (11.5–54.5) | 21.5 (17–28.3) |
> 40 U/L | 5 (38.5) | 4 (30.8) | 3/12 (25) | 2/8 (25) | 1/12 (8.3) |
AST (0–40 U/L) | 32 (20.5–45) | 32 (23–39.5) | 23 (17–34.8) | 27 (15–41.3) | 25 (14.8–30.8) |
> 40 U/L | 4 (30.8) | 3 (23.1) | 2/12 (16.7) | 2/8 (25) | 1/12 (8.3) |
GGT (0–58 U/L) | 50 (29–121) | 61 (37–132) | 42.5 (28.3–103) | 78 (33–182.8) | 50 (30–93.5) |
> 58 U/L | 4 (30.8) | 7 (53.8) | 4/12 (33.3) | 5/8 (62.5) | 4/12 (33.3) |
ALP (40–130 U/L) | 66 (57.5–69.5) | 63 (54.5–81) | 63 (46.3–85.5) | 65.5 (37.5–75.8) | 63 (52–70.5) |
> 130 U/L | 1 (7.7) | 0 (0) | 1/12 (8.3) | 0/8 (0) | 0/12 (0) |
ALB (35–55 g/L) | 35.1 (33.5–41.5) | 34 (30–40.5) | 32.8 (31.2–37.6) | 36.7 (32.4–37.9) | 33.2 (31.5–36.3) |
< 35 g/L | 5 (38.5) | 8 (61.5) | 6/12 (50) | 3/8 (37.5) | 7/12 (58.3) |
TBIL (0–25 μmol/L) | 15 (10.2–19.4) | 10.4 (9.6–20.3) | 12.5 (6.8–24.4) | 8.5 (5.3–20.5) | 10.7 (8.1–16.9) |
> 25 μmol/L | 0 (0) | 0 (0) | 3/12 (25) | 1/8 (12.5) | 0/12 (0) |