| |
Day − 3 to − 7
|
Day 1
|
Day 5a
|
Day 10b
|
Viral clearancec
|
|---|
|
ALT (0–40 U/L)
|
22 (19–76)
|
21 (15.5–67.5)
|
23.5 (14.8–73.8)
|
24 (11.5–54.5)
|
21.5 (17–28.3)
|
|
> 40 U/L
|
5 (38.5)
|
4 (30.8)
|
3/12 (25)
|
2/8 (25)
|
1/12 (8.3)
|
|
AST (0–40 U/L)
|
32 (20.5–45)
|
32 (23–39.5)
|
23 (17–34.8)
|
27 (15–41.3)
|
25 (14.8–30.8)
|
|
> 40 U/L
|
4 (30.8)
|
3 (23.1)
|
2/12 (16.7)
|
2/8 (25)
|
1/12 (8.3)
|
|
GGT (0–58 U/L)
|
50 (29–121)
|
61 (37–132)
|
42.5 (28.3–103)
|
78 (33–182.8)
|
50 (30–93.5)
|
|
> 58 U/L
|
4 (30.8)
|
7 (53.8)
|
4/12 (33.3)
|
5/8 (62.5)
|
4/12 (33.3)
|
|
ALP (40–130 U/L)
|
66 (57.5–69.5)
|
63 (54.5–81)
|
63 (46.3–85.5)
|
65.5 (37.5–75.8)
|
63 (52–70.5)
|
|
> 130 U/L
|
1 (7.7)
|
0 (0)
|
1/12 (8.3)
|
0/8 (0)
|
0/12 (0)
|
|
ALB (35–55 g/L)
|
35.1 (33.5–41.5)
|
34 (30–40.5)
|
32.8 (31.2–37.6)
|
36.7 (32.4–37.9)
|
33.2 (31.5–36.3)
|
|
< 35 g/L
|
5 (38.5)
|
8 (61.5)
|
6/12 (50)
|
3/8 (37.5)
|
7/12 (58.3)
|
|
TBIL (0–25 μmol/L)
|
15 (10.2–19.4)
|
10.4 (9.6–20.3)
|
12.5 (6.8–24.4)
|
8.5 (5.3–20.5)
|
10.7 (8.1–16.9)
|
|
> 25 μmol/L
|
0 (0)
|
0 (0)
|
3/12 (25)
|
1/8 (12.5)
|
0/12 (0)
|
- Data are presented as median (interquartile range), n (%), or n/N (%), where N is the total number of cases with available data
- aData were unavailable in 1 patient because viral shedding discontinuation occurred on day 4
- bData were unavailable in 5 patients because viral shedding discontinuation occurred before day 10
- cData were unavailable in 1 patient because he did not clear the virus until death. The corresponding normal ranges and units of the liver function test parameters are presented in parentheses
