Table 3 Dynamic abnormal rates and levels of liver function test parameters between various viral shedding timepoints in patients with COVID-19
|
Day −(3–7) (n = 70) |
Day 1 (n = 70) |
Day 5 (n = 65) |
Day 10 (n = 41) |
Day-clearance (n = 62) | p1 | p2 | p3 | p4 | |
|---|---|---|---|---|---|---|---|---|---|
| ALT (0–40 U/L) | 21 (13–27.3) | 21 (14–28) | 21 (15–31) | 22 (17–34.5) | 20 (13.8–29) | 0.901 | 0.774 | 0.094 | 0.682 |
| > 40 U/L | 10 (14.3) | 8 (11.4) | 11 (16.9) | 8 (19.5) | 7 (11.3) | 0.614 | 0.673 | 0.471 | 0.608 |
| AST (0–40 U/L) | 23 (19–32) | 24 (19–32) | 24 (19–33) | 25 (17–33.5) | 22.4 (16–32) | 0.567 | 0.642 | 0.270 | 0.734 |
| > 40 U/L | 7 (10) | 7 (10) | 9 (13.8) | 6 (14.6) | 6 (9.7) | - | 0.490 | 0.669 | 0.951 |
| GGT (0–58 U/L) | 33.5 (22–48) | 33 (23.8–51) | 33.5 (23–58) | 43 (26–67) | 33 (24–66.8) | 0.338 | 0.360 | 0.033 | 0.346 |
| > 58 U/L | 9 (12.9) | 15 (21.4) | 14 (21.5) | 14 (34.1) | 19 (30.6) | 0.178 | 0.180 | 0.008 | 0.013 |
| ALP (40–130 U/L) | 59.5 (53.8–67) | 57.5 (47–73.3) | 64 (50.3–80) | 73 (57–93) | 67 (51–78) | 0.337 | 0.189 | 0.001 | 0.042 |
| > 130 U/L | 2 (2.9) | 1 (1.4) | 7 (10.8) | 4 (9.8) | 1 (1.6) | 1.000 | 0.088 | 0.191 | 1.000 |
| ALB (35–55 g/L) | 37 (34–40.1) | 36 (31.3–40) | 35 (31.3–38) | 34.2 (31.4–38) | 34.5 (31.7–37.2) | < 0.001 | < 0.001 | 0.016 | < 0.001 |
| < 35 g/L | 15 (21.4) | 30 (42.9) | 29 (44.6) | 23 (56.1) | 32 (51.6) | 0.007 | 0.004 | < 0.001 | < 0.001 |
| TBIL (0–25 μmol/L) | 11.5 (8–18.6) | 12.2 (9.3–23.5) | 14 (9–21.5) | 14.8 (8.5–27.7) | 11.8 (8.2–21.1) | 0.018 | 0.034 | 0.068 | 0.056 |
| > 25 μmol/L | 4 (5.7) | 12 (17.1) | 14 (21.5) | 9 (22) | 10 (16.1) | 0.034 | 0.007 | 0.024 | 0.052 |