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Table 3 Dynamic abnormal rates and levels of liver function test parameters between various viral shedding timepoints in patients with COVID-19

From: Dynamic changes in liver function parameters in patients with coronavirus disease 2019: a multicentre, retrospective study

  Day −(3–7)
(n = 70)
Day 1
(n = 70)
Day 5
(n = 65)
Day 10
(n = 41)
Day-clearance
(n = 62)
p1 p2 p3 p4
ALT (0–40 U/L) 21 (13–27.3) 21 (14–28) 21 (15–31) 22 (17–34.5) 20 (13.8–29) 0.901 0.774 0.094 0.682
 > 40 U/L 10 (14.3) 8 (11.4) 11 (16.9) 8 (19.5) 7 (11.3) 0.614 0.673 0.471 0.608
AST (0–40 U/L) 23 (19–32) 24 (19–32) 24 (19–33) 25 (17–33.5) 22.4 (16–32) 0.567 0.642 0.270 0.734
 > 40 U/L 7 (10) 7 (10) 9 (13.8) 6 (14.6) 6 (9.7) - 0.490 0.669 0.951
GGT (0–58 U/L) 33.5 (22–48) 33 (23.8–51) 33.5 (23–58) 43 (26–67) 33 (24–66.8) 0.338 0.360 0.033 0.346
 > 58 U/L 9 (12.9) 15 (21.4) 14 (21.5) 14 (34.1) 19 (30.6) 0.178 0.180 0.008 0.013
ALP (40–130 U/L) 59.5 (53.8–67) 57.5 (47–73.3) 64 (50.3–80) 73 (57–93) 67 (51–78) 0.337 0.189 0.001 0.042
 > 130 U/L 2 (2.9) 1 (1.4) 7 (10.8) 4 (9.8) 1 (1.6) 1.000 0.088 0.191 1.000
ALB (35–55 g/L) 37 (34–40.1) 36 (31.3–40) 35 (31.3–38) 34.2 (31.4–38) 34.5 (31.7–37.2)  < 0.001  < 0.001 0.016  < 0.001
 < 35 g/L 15 (21.4) 30 (42.9) 29 (44.6) 23 (56.1) 32 (51.6) 0.007 0.004  < 0.001  < 0.001
TBIL (0–25 μmol/L) 11.5 (8–18.6) 12.2 (9.3–23.5) 14 (9–21.5) 14.8 (8.5–27.7) 11.8 (8.2–21.1) 0.018 0.034 0.068 0.056
 > 25 μmol/L 4 (5.7) 12 (17.1) 14 (21.5) 9 (22) 10 (16.1) 0.034 0.007 0.024 0.052
  1. Data are presented as median (interquartile range) and n (%). The corresponding normal ranges and units of the liver function test parameters are presented in parentheses. Data were unavailable for patients on day 5 (n = 5), 10 (n = 29), and at viral clearance (n = 8) because viral shedding discontinuation occurred before this timepoint or because the virus was not cleared until death (day-clearance timepoint). p1: day −(3–7) vs day 1, p2: day −(3–7) vs day 5, p3: day −(3–7) vs day 10, p4: day −(3–7) vs day clearance