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Table 2 Dynamic abnormal rates of liver function test parameters in different groups of patients with COVID-19

From: Dynamic changes in liver function parameters in patients with coronavirus disease 2019: a multicentre, retrospective study

 

Total (n = 70)

Non-ICU (n = 30)

ICU (n = 23)

Fatality (n = 17)

p1

p2

p3

Day 3–7 before viral shedding

       

 ALT increased (0–40 U/L)

10 (14.3)

5 (16.7)

3 (13)

2 (11.8)

1.000

1.000

1.000

 AST increased (0–40 U/L)

7 (10)

2 (6.7)

3 (13)

2 (11.8)

0.642

0.613

1.000

 GGT increased (0–58 U/L)

9 (12.9)

5 (16.7)

2 (8.7)

2 (11.8)

0.685

1.000

1.000

 ALP increased (40–130 U/L)

2 (2.9)

1 (3.3)

0 (0)

1 (5.9)

1.000

1.000

0.425

 ALB decreased (35–55 g/L)

15 (21.4)

6 (20)

4 (17.4)

5 (29.4)

1.000

0.709

0.605

 TBIL increased (0–25 μmol/L)

4 (5.7)

0 (0)

2 (8.7)

2 (11.8)

0.184

0.126

1.000

During viral shedding, on day 1

       

 ALT increased (0–40 U/L)

8 (11.4)

4 (13.3)

1 (4.3)

3 (17.6)

0.374

0.692

0.294

 AST increased (0–40 U/L)

7 (10)

3 (10)

1 (4.3)

3 (17.6)

0.624

0.653

0.294

 GGT increased (0–58 U/L)

15 (21.4)

8 (26.7)

3 (13)

4 (23.5)

0.384

1.000

0.432

 ALP increased (40–130 U/L)

1 (1.4)

1 (3.3)

0 (0)

0 (0)

1.000

1.000

-

 ALB decreased (35–55 g/L)

30 (42.9)

10 (33.3)

10 (43.5)

10 (58.8)

0.450

0.089

0.337

 TBIL increased (0–25 μmol/L)

12 (17.1)

5 (16.7)

3 (13)

4 (23.5)

1.000

0.850

0.432

During viral shedding, on day 5

       

 ALT increased (0–40 U/L)

11/65 (16.9)

5/26 (19.2)

2 (8.7)

4/16 (25)

0.424

0.956

0.205

 AST increased (0–40 U/L)

9/65 (13.8)

1/26 (3.8)

2 (8.7)

6/16 (37.5)

0.594

0.008

0.045

 GGT increased (0–58 U/L)

14/65 (21.5)

7/26 (26.9)

5 (21.7)

2/16 (12.5)

0.674

0.472

0.678

 ALP increased (40–130 U/L)

7/65 (10.8)

2/26 (7.7)

1 (4.3)

4/16 (25)

1.000

0.180

0.139

 ALB decreased (35–55 g/L)

29/65 (44.6)

7/26 (26.9)

13 (56.5)

9/16 (37.5)

0.035

0.057

1.000

 TBIL increased (0–25 μmol/L)

14/65 (21.5)

5/26 (19.2)

2 (8.7)

7/16 (43.8)

0.424

0.175

0.019

During viral shedding, on day 10

       

 ALT increased (0–40 U/L)

8/41 (19.5)

0/8 (0)

4/20 (20)

4/13 (30.8)

0.295

0.131

0.681

 AST increased (0–40 U/L)

6/41 (14.6)

0/8 (0)

2/20 (10)

4/13 (30.8)

1.000

0.131

0.182

 GGT increased (0–58 U/L)

14/41 (34.1)

3/8 (37.5)

7/20 (35)

4/13 (30.8)

1.000

1.000

1.000

 ALP increased (40–130 U/L)

4/41 (9.8)

0/8 (0)

0/20 (0)

4/13 (30.8)

-

0.131

0.017

 ALB decreased (35–55 g/L)

23/41 (56.1)

5/8 (62.5)

10/20 (50)

8/13 (61.5)

0.686

1.000

0.722

 TBIL increased (0–25 μmol/L)

9/41 (22)

0/8 (0)

0/20 (0)

9/13 (69.2)

-

0.005

 < 0.001

On the day of viral clearance

       

 ALT increased (0–40 U/L)

7/62 (11.3)

3 (10)

2 (8.7)

2/9 (22.2)

1.000

0.572

0.557

 AST increased (0–40 U/L)

6/62 (9.7)

0 (0)

2 (8.7)

4/9 (44.4)

0.184

0.002

0.038

 GGT increased (0–58 U/L)

19/62 (30.6)

9 (30)

8 (34.8)

2/9 (22.2)

0.712

0.974

0.681

 ALP increased (40–130 U/L)

1/62 (1.6)

0 (0)

1 (4.3)

0/9 (0)

0.434

-

1.000

 ALB decreased (35–55 g/L)

32/62 (51.6)

13 (43.3)

14 (60.9)

5/9 (55.6)

0.206

0.706

1.000

 TBIL increased (0–25 μmol/L)

10/62 (16.1)

3 (10)

2 (8.7)

5/9 (55.6)

1.000

0.009

0.010

  1. Data are presented as n (%) or n/N (%), where N is the total number of cases with available data. Data were unavailable in some patients because viral shedding discontinuation occurred before this timepoint or viruses were not cleared until death (fatality group). The corresponding normal ranges and units of the liver function test parameters are presented in parentheses; increased indicates over the upper limit of the normal range, and decreased indicates below the lower limit of the normal range. p1: non-ICU vs ICU groups, p2: non-ICU vs fatality, p3: ICU vs fatality
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BMC Infectious Diseases

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