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Table 6 Comparison of demographic and clinical characteristics between survivors and non-survivors

From: Epidemiology of patients with central nervous system infections, mainly neurosurgical patients: a retrospective study from 2012 to 2019 in a teaching hospital in China

Characteristics Total (N = 72) Survivors (N = 50) Non-Survivors (N = 22) P
Age (years) 49.7 ± 18.3 45.5 ± 17.8 59.0 ± 16.3 0.003
Age > 50 41 23 18 0.005
Sex
 Male 54 (75.0) 36 (72.0) 18 (81.8) 0.375
 Female 18 (25.0) 14 (28.0) 4 (18.2)
Days in hospital 29.5 (19.3–46.0) 29.0 (20.7–45.0) 33.5 (18.0–51.0) 0.633
Comorbidity
 Pulmonary infection 35 (48.6) 15 (30.0) 20 (90.9) < 0.001
 Hypertension 29 (40.3) 16 (32.0) 13 (59.1) 0.031
 Hydrocephalus 26 (36.1) 16 (32.0) 10 (45.5) 0.274
 Intracranial hemorrhage 19 (26.4) 13 (26.0) 6 (27.3) 0.91
 Diabetes 10 (13.9) 5 (10.0) 5 (22.7) 0.285
 MDR bacteria infection 49 (68.1) 31 (62.0) 18 (81.8) 0.097
 Glucocorticoid therapy > 3 days 29 (40.3) 18 (36.0) 11 (50.0) 0.265
Surgery
 Yes 50 (69.4) 33 (66.0) 17 (77.3) 0.339
 No 22 (30.6) 17 (34.0) 5 (22.7)
Invasive device
 External ventricular drainage/Lumbar cistern drainage 41 (56.9) 25 (50.0) 16 (72.7) 0.073
 Catheter 57 (79.2) 37 (74.0) 20 (90.9) 0.189
CSF data
 ADA level (U/L) 15.50 (4.33–30.95) 14.00 (3.30–28.25) 19.55 (5.48–37.48) 0.131
 Glucose level (mmol/L) 1.71 (0.21–2.98) 2.29 (1.35–3.46) 0.35 (0.05–0.91) < 0.001
 Chlorine level (mmol/L) 116.68 ± 9.27 117.16 ± 8.67 115.58 ± 10.63 0.508
 Protein level (g/L) 2.37 (1.12–4.01) 1.67 (0.84–2.78) 4.00 (2.98–4.54) < 0.001
 Leukocyte count (× 106/L) 340.0 (52.5–2400.0) 188.0 (27.5–927.5) 1125.0 (102.5–4185.0) 0.029
 Erythrocyte count (× 106/L) 395.0 (10.0–4787.5) 395.0 (7.5–1987.5) 810.0 (65.0–10,675.0) 0.306
Blood data
 White blood cell level (× 109/L) 13.13 ± 6.11 12.42 ± 5.64 14.75 ± 6.94 0.138
 Neutrophils level (× 109/L) 10.55 (6.94–13.48) 10.13 (6.58–12.68) 12.56 (8.68–14.85) 0.071
 Percentage of neutrophils 85.21 (78.86–88.05) 84.35 (76.36–87.49) 87.14 (83.40–88.88) 0.039
Liver function
 ALT (U/L) 22.80 (14.63–57.93) 20.80 (14.08–46.35) 36.60 (19.40–125.15) 0.018
 AST (U/L) 22.60 (17.03–39.45) 20.05 (15.53–38.03) 31.80(19.25–66.28) 0.014
 TBIL (mmol/L) 14.65 (10.13–18.60) 13.90 (9.40–18.30) 15.05 (12.88–21.48) 0.167
 ALP (U/L) 89.5 (72.0–127.0) 82.0 (70.5–118.0) 104.0 (77.8–170.5) 0.069
 Total protein (g/L) 63.22 ± 8.06 64.30 ± 8.04 60.76 ± 7.73 0.086
 Albumin (g/L) 35.93 ± 6.62 37.75 ± 5.51 31.79 ± 7.15 < 0.001
Renal function
 Urea nitrogen (mmol/L) 5.05 (3.58–6.95) 4.72 (2.98–6.58) 6.13 (4.63–8.60) 0.02
 Creatinine (mmol/L) 61.53 ± 25.25 61.27 ± 27.27 62.14 ± 20.51 0.893