Table. 2 Virologic, biochemical, and serologic responses of ETV-resistance patients with/or without ADV resistance in different rescue therapy at Week 48
ETV + ADV | TDF | TDF + ETV | |
|---|---|---|---|
N | 25 | 27 | 20 |
HBV DNA < 100 IU/mL, n (%) | 7, 28.00% | 20, 74.07% | 14, 70% |
HBV DNA change from baseline (log10 IU/mL) | 3.86 ± 1.62 | 4.55 ± 1.81 | 5.33 ± 1.88 |
Residual HBV DNA level (log10 IU/mL) | 2.44 | 0.86 | 0.8 |
Virologic breakthrough | 1 | 0 | 0 |
ALT (IU/L) | 40.56 | 45.33 | 34.82 |
ALT normal, n (%) | 19, 76.00% | 23, 85.19% | 16, 80.00% |
Abnormal renal function | 0 | 1 | 1 |
HBeAg seroclearance, n (%) | 0 | 3 | 1 |
HBeAg seroconversion, n (%) | 0 | 1 | 1 |
HBsAg seroclearance, n (%) | 0 | 0 | 0 |
Discontinued | 3 | 1 | 0 |