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Table 7 Accuracy of six clinical algorithms for the diagnosis of neuritis in leprosy patients with neural pain (n = 124)

From: Clinical prediction rules for the diagnosis of neuritis in leprosy

Clinical algorithms Se % (95% CI) Sp % (95% CI) PPV % (95% CI) NPV % (95% CI) PLR % (95% CI) NLR % (95% CI) DOR (95% CI)
Pain onset < 90 days OR pain with neurological symptoms ≤ 30 days AND movement as worsening pain factor
AND spontaneously-declared triggering of pain by palpation
20.00 (8.07–41.60) 97.12 (91.86–99.01) 57.1 (26.02–83.48) 86.3 (83.35–88.84) 6.93 (1.68–28.64) 0.82 (0.66–1.03) 8.42 (1.72–41.16)
Pain onset < 90 days OR pain with neurological symptoms ≤ 30 days
AND movement as worsening pain factor
AND triggering of pain by palpation
35.00 (18.12–56.71) 94.23 (87.98–97.33) 53.8 (31.06–75.13) 88.30 (84.42–91.30) 6.07 (2.28–16.16) 0.69 (0.50–0.95) 8.80 (2.56–30.22)
Pain onset < 90 days OR pain with neurological symptoms ≤ 30 days
AND spontaneously-declared triggering of pain by palpation
20.00 (8.07–41.60) 91.35 (8.37–95.38) 30.80 (13.61–55.63) 85.60 (82.41–88.27) 2.31 (0.79–6.78) 0.88 (0.70–1.10) 2.64 (0.72–9.60)
Pain onset < 90 days OR pain with neurological symptoms ≤ 30 days
AND triggering of pain by palpation
40.0 (21.88–61.34) 86.54 (78.66–91.81) 36.4 (21.83–53.91) 88.20 (83.83–91.56) 2.97 (1.44–6.13) 0.69 (0.48–1.0) 4.29 (1.49–12.33)
Pain onset < 90 days OR pain with neurological symptoms ≤ 30 days
AND physical exertion and movement as worsening pain factors
AND spontaneously-declared triggering of pain by palpation
20.00 (8.07–41.60) 95.19 (89.24–97.93) 44.4 (19.87–72.08) 86.1 (83.05–88.65) 4.16 (1.22–14.16) 0.84 (0.67–1.05) 4,95 (1.20–20.42)
Pain onset < 90 days OR pain with neurological symptoms ≤ 30 days
AND physical exertion and movement as worsening pain factors
AND triggering of pain by palpation
35.0 (18.12–56.71) 91.35 (84.37–95.38) 43.7 (25.01–64.46) 88.0 (83.98–91.06) 4.04 (1.70–9.60) 0.71 (0.51–0.99) 5.68 (1.81–17.86)
  1. Se sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, PLR positive likelihood ratio, NLR negative likelihood ratio, DOR diagnostic odds ratio, 95% CI 95% confidence interval