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Table 1 Distribution of antimicrobial use, individually or by class, expressed in percentages, DOT and LOT per 1000 patient-days (pd), and the DOT/LOT ratio, by hospital ward, 2018

From: Use of monitoring indicators in hospital management of antimicrobials

Variables

Wards

SUR

MED

PNE/INF

PED

ICU

p-value

Use of antimicrobials (%)

38.0a

42.0b

62.0c(a)

64.0d(a)

86.0e(ab)

0.000*

Number of prescriptions (%)

      

 First-generation cephalosporins IV/PO

49.4a(bce)

3.9b

1.4c

34.5d(bc)

9.6e

0.000*

 Fluoroquinolones IV/PO

20.5a

14.2b

11.2c

3.6d(abe)

13.7e

0.000*

 Carbapenems IV

1.7a

11.6b(a)

8.8c

6.3d

19.6e(ad)

0.000*

 Third-generation cephalosporins IV

6.5a

14.8b(ae)

8.5c

9.2d

4.1e

0.011*

 Metronidazole IV/PO

10.1a

5.8b

1.7c(ae)

6.3d

11.3e

0.001*

 Cefepime IV

0.8a

10.3b(a)

15.6c(a)

6.0d

7.2e

0.000*

 Clindamycin IV

9.1

7.1

5.1

2.1

7.6

0.102

 Antifungals IV/PO

0.2a

7.1b(a)

16.0c(ad)

4.5d

6.9e

0.000*

 Glycopeptides IV

1.1a

6.5b

3.4c

3.0d

10.7e(acd)

0.001*

 Azithromycin IV/PO

0a

2.6b

9.5c(abe)

6.3d(a)

1.7e

0.000*

 Penicillins1 IV/PO

0.2a

10.3b(ae)

3.4c

8.3d(ae)

1.0e

0.000*

 Co-trimoxazole IV/PO

0a

3.2b

10.9c(abe)

3.6d(a)

3.1e

0.000*

 Aminoglycosides IV

0.4a

2.6b

4.4c

6.5d(a)

3.4e

0.017*

ID LOT/1000pd

300a

262b

470c(ab)

382d(b)

753e(abcd)

0.000*

ID DOT/1000pd

      

 Fluoroquinolones IV/PO

108a

57b

71c

28d(ae)

147e

0.001*

 First-generation cephalosporins IV/PO

123a(bc)

6b

6c

94d(bc)

73e(bc)

0.000*

 Carbapenems IV

11a

43b

84c(a)

40d

368e(abd)

0.000*

 Third-generation cephalosporins IV

43

57

64

61

35

0.519

 Cefepime IV

8a(ce)

32b

95c

47d

114e

0.000*

 Metronidazole IV/PO

56a

12b(e)

8c(ade)

59d

119e

0.000*

 Antifungals IV/PO

1a(ce)

24b

83c

40d

118e

0.000*

 Co-trimoxazole IV/PO

0a

4b(c)

121c(ab)

25d

72e(a)

0.000*

 Clindamycin IV

47

28

37

12

73

0.099

 Glycopeptides IV

8a

25b

36c

10d

183e(abcd)

0.000*

 Aminoglycosides IV

6

16

32

34

83

0.055

 Penicillins1 IV/PO

1a

35b(a)

18c

38d(ae)

13e

0.000*

 Azithromycin IV/PO

0a(cd)

10b(c)

40c

31d

23e

0.000*

ID DOT/LOT ratio

1.4a

1.3b

1.5c

1.4d

2.0e(abcd)

0.000*

  1. ID Incidence Density, SUR Surgical Clinic, MED Medical Clinic, PNE/INF Pneumology/Infectology, PED Pediatrics, ICU Intensive Care Unit
  2. 1Penicillin/penicillin with beta-lactamase inhibitor
  3. a,b,c,d,eStatistical differences per line (Bonferroni *p < 0.05)