Skip to main content

Table 1 Reported cases of endocarditis due to Nocardia species

From: A case report of Nocardia spp. infective endocarditis in an injection drug user

References Age (y)/sex Predisposing risk factor Site of involvement Nocardia species Antimicrobial treatment (Duration) Surgery Outcome
Allevato et al. [8] 53/M PAV RAA N. asteroides Streptomycin, tetracycline, vancomycin, sulfonamides N/A Died
Antony et al. [9] 74/F HTN, valvular heart disease, HLD NMV N. asteroides Imipenem, ceftriaxone (6 weeks), TMP-SMX (6 months) MVR Survived
Antonovich et al. [10] 83/F COPD, MVP, breast & endometrial cancer, systemic steroids NMV N. asteroides TMP-SMX N/A Survived
Cargill et al. [11] 85/F Ischemic heart disease, COPD, polymyalgia rheumatic, systemic steroids NMV N. cyriacigeorgica Vancomycin, pip/tazo, imipenem, doxycycline N/A Died
Castelli et al. [12] 36/M Liver transplant NMV N. species Ceftriaxone, vancomycin, TMP-SMX MVR
(× 2)
Survived
Daikos et al. [13] 61/F PAV PAV N. asteroides Imipenem/cilastatin, amikacin (2 months),
TMP-SMX (4 months)
N/A Survived
Dhawan et al. [14] 46/F N/A NMV N. species PCN, nafcillin, gentamicin, TMP-SMX, imipenem/cilastatin MVR Survived
Eigel et al. [15] 61/M PAV PAV N. asteroides Amikacin, imipenem/cilastatin,
cefotiam (3 weeks)
AVR Survived
Eigel et al. [15] 65/M PAV PAV N. asteroides N/A N/A Died
Ertl et al. [16] 61/M PAV PAV N. asteroides Amoxicillin, mezlocillin, tobramycin, sulphadiazine, amikacin, amoxicillin-clavulanate, imipenem (3 weeks), TMP-SMX AVR Survived
Falk et al. [17] 64/F PAV PAV N. asteroides Ampicillin, gentamicin N/A Died
Gupta et al. [18] 53/F History of breast cancer NAV N. species Meropenem, amikacin, TMP-SMX, linezolid
(8 months)
AVR Survived
Hazim et al. [19] 64/M Heart transplant, CKD NTV N. asteroides TMP-SMX, imipenem/cilastatin, ceftriaxone, minocycline, linezolid (7 months) N/A Survived
Jackson et al. [20] 39/M Splenectomy, tobacco use, HCV, IVDU NTV N. francinia Meropenem, vancomycin, TMP-SMX N/A Lost to follow-up
Kuretski et al. [21] 58/F History of oral cancer, COPD, PFO repair, tobacco use NMV N. farcinica Ceftriaxone, meropenem, amikacin, ciprofloxacin MVR Survived
Majeed et al. [22] 72/M Lymphoma NMV N. kroppenstedtii Meropenem, TMP-SMX, levofloxacin, linezolid, ceftriaxone, minocycline, ciprofloxacin N/A Died
Vlachakis et al. [23] 34/F PMV, rheumatic heart disease PMV N. asteroides N/A N/A Died
Watson et al. [24] 39/M IVDU NAV N. asteroides Meropenem, ceftriaxone, amikacin, cefpodoxime, TMP-SMX (6 months) AVR Survived
  1. AVR, aortic valve replacement; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; HCV, Hepatitis C virus; HLD, hyperlipidemia; HTN, hypertension; IVDU, intravenous drug use; MVP, mitral valve prolapse; MVR, mitral valve replacement; NAV, native aortic valve; NMV, native mitral valve; NTV, native tricuspid valve; PFO, patent foramen ovale; Pip/tazo, piperacillin and tazobactam; PCN, penicillin; PAV, prosthetic aortic valve; PMV, prosthetic mitral valve; PV, prosthetic valve; RAA, root of ascending aorta; TMP-SMX, trimethoprim sulfamethoxazole