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Table 1 Summary of studies included in the meta-analysis

From: Efficacy of tetracyclines and fluoroquinolones for the treatment of macrolide-refractory Mycoplasma pneumoniae pneumonia in children: a systematic review and meta-analysis

Study author (year)

Country

Age*

Number of subjects

Treatment

Outcome measure analyzed

Intervention

Control

Intervention

Control

Intervention

Control

Han (2016)

[19]

China

9.54 ± 1.20

10.32 ± 1.76

TET (n = 29)

Macrolide (n = 30)

AZM therapy same as the control, with the addition of MIN HCl 4 mg/kg once, followed by 2 mg/kg orally 24 h later and every 12 h for 5 days

AZM 10 mg/kg/d, intravenously for 5 days, and then discontinued for 3 days. If necessary, two courses were administered

Fever duration, hospital stay length

Li (2017)

[20]

China

10.54 ± 0.38

10.61 ± 0.36

TET (n = 21)

Macrolide (n = 21)

AZM therapy same as the control, with the addition of MIN50 mg orally twice daily

AZM 10 mg/kg/day, intravenously for 5 days, and then discontinued for 3 days. If necessary, a second course was administered for 3 days

Fever duration, therapeutic efficacy

Zhang (2016)

[21]

China

10.3 ± 1.7

10.1 ± 1.7

TET (n = 28)

Macrolide (n = 29)

MIN 100 mg orally twice daily for 2 weeks

CLR 250 mg three times daily for 2 weeks

Fever duration, length of hospital stay, therapeutic efficacy

Okada (2012)

[22]

Japan

8 (1–14)

TET (n = 68)

Fluoroquinolone (n = 13)

Macrolide (n = 13)

MIN 4 mg/kg/day twice daily; DOX 4 mg/kg/day twice daily; tosufloxacin 12 mg/kg/day twice daily

AZM, CLR

Defervescence after 24, 48, and 72 h

Ye (2016)

[23]

China

9.2 ± 1.6

9.3 ± 1.0

TET (n = 23)

Macrolide (n = 21)

DOX 4 mg/kg/d

AZM 10 mg/kg/day

Defervescence after 24, 48, and 72 h

Kawai (2012)

[24]

Japan

Unknown

TET (n = 15)

Macrolide (n = 21)

MIN 2–4 mg/kg/day

AZM 10 mg/kg/day; CLR 10–15 mg/kg/day

Defervescence after 48 h

Kawai (2013)

[25]

Japan

8.0 (0–15)

TET (n = 38)

Fluoroquinolone

(n = 62)

Macrolide (n = 50)

MIN 4 mg/kg twice daily; tosufloxacin 12 mg/kg twice daily

AZM 10 mg/kg once daily; CLR 15 mg/kg twice daily

Defervescence after 48 h

Ishiguro (2017)

[26]

Japan

9.0 ± 3.2

Fluoroquinolone

(n = 8)

Macrolide

(n = 47)

MIN 2–4 mg/kg/day for 2–4 days; tosufloxacin 12 mg/kg/day for 3–7 days

AZM 10 mg/kg/day for 3 days; CLR 10–15 mg/kg/day for 3–7 days

Defervescence after 24, 48, and 72 h

  1. AZM azithromycin, CLR clarithromycin, DOX doxycycline, MIN minocycline, TET tetracycline
  2. *Presented as mean ± standard deviation or median (range)