Study author (year) | Country | Age* | Number of subjects | Treatment | Outcome measure analyzed | |||
---|---|---|---|---|---|---|---|---|
Intervention | Control | Intervention | Control | Intervention | Control | |||
Han (2016) [19] | China | 9.54 ± 1.20 | 10.32 ± 1.76 | TET (n = 29) | Macrolide (n = 30) | AZM therapy same as the control, with the addition of MIN HCl 4 mg/kg once, followed by 2 mg/kg orally 24 h later and every 12 h for 5 days | AZM 10 mg/kg/d, intravenously for 5 days, and then discontinued for 3 days. If necessary, two courses were administered | Fever duration, hospital stay length |
Li (2017) [20] | China | 10.54 ± 0.38 | 10.61 ± 0.36 | TET (n = 21) | Macrolide (n = 21) | AZM therapy same as the control, with the addition of MIN50 mg orally twice daily | AZM 10 mg/kg/day, intravenously for 5 days, and then discontinued for 3 days. If necessary, a second course was administered for 3 days | Fever duration, therapeutic efficacy |
Zhang (2016) [21] | China | 10.3 ± 1.7 | 10.1 ± 1.7 | TET (n = 28) | Macrolide (n = 29) | MIN 100 mg orally twice daily for 2 weeks | CLR 250 mg three times daily for 2 weeks | Fever duration, length of hospital stay, therapeutic efficacy |
Okada (2012) [22] | Japan | 8 (1–14) | TET (n = 68) Fluoroquinolone (n = 13) | Macrolide (n = 13) | MIN 4 mg/kg/day twice daily; DOX 4 mg/kg/day twice daily; tosufloxacin 12 mg/kg/day twice daily | AZM, CLR | Defervescence after 24, 48, and 72 h | |
Ye (2016) [23] | China | 9.2 ± 1.6 | 9.3 ± 1.0 | TET (n = 23) | Macrolide (n = 21) | DOX 4 mg/kg/d | AZM 10 mg/kg/day | Defervescence after 24, 48, and 72 h |
Kawai (2012) [24] | Japan | Unknown | TET (n = 15) | Macrolide (n = 21) | MIN 2–4 mg/kg/day | AZM 10 mg/kg/day; CLR 10–15 mg/kg/day | Defervescence after 48 h | |
Kawai (2013) [25] | Japan | 8.0 (0–15) | TET (n = 38) Fluoroquinolone (n = 62) | Macrolide (n = 50) | MIN 4 mg/kg twice daily; tosufloxacin 12 mg/kg twice daily | AZM 10 mg/kg once daily; CLR 15 mg/kg twice daily | Defervescence after 48 h | |
Ishiguro (2017) [26] | Japan | 9.0 ± 3.2 | Fluoroquinolone (n = 8) | Macrolide (n = 47) | MIN 2–4 mg/kg/day for 2–4 days; tosufloxacin 12 mg/kg/day for 3–7 days | AZM 10 mg/kg/day for 3 days; CLR 10–15 mg/kg/day for 3–7 days | Defervescence after 24, 48, and 72 h |