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Table 3 Analysis of concordance and discordance between IGRA and TST

From: Tuberculosis infection screening in children with close contact: a hospital-based study

Risk group

IGRA+/TST+ n (%)

IGRA−/TST+ n(%)

IGRA+/TST−

n(%)

IGRA−/TST−

n(%)

Kappa value

P value

Ratio of

OR(95%CI)

 

TST+/IGRA− and TST−/IGRA+

IGRA+/TST+

vs. IGRA−/TST−

IGRA+/TST− vs. IGRA−/TST−

IGRA−/TST+ vs. IGRA−/TST−

No reported contact risk (n = 5833)

15 (0.3%)

136 (2.3%)

26 (0.4%)

5656 (97.0%)

0.15

 < 0.001

5.2

Reference

Reference

Reference

Non-household contact risk (n = 274)

6 (2.2%)

17 (6.2%)

0 (0)

251 (91.6%)

0.39

 < 0.001

9.0 (3.5–23.4)

1.0 (0.99–1.0)

2.8 (1.7–4.7)

Household contact risk (n = 95)

4 (4.2%)

13 (13.7%)

1 (1.1%)

77 (81.1%)

0.31

 < 0.001

13

19.6 (6.4–60.4)

2.8 (0.4–21.1)

7.0 (3.8–12.9)

  1. TST using 10 mm as a cutoff and IGRA using 8 spots as a cutoff
  2. IGRA interferon-gamma release assay, TST tuberculin skin test, RID respiratory and infectious diseases, OR odds ratio, CI confidence interval