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Table 3 Analysis of concordance and discordance between IGRA and TST

From: Tuberculosis infection screening in children with close contact: a hospital-based study

Risk group IGRA+/TST+ n (%) IGRA−/TST+ n(%) IGRA+/TST−
n(%)
IGRA−/TST−
n(%)
Kappa value P value Ratio of OR(95%CI)
  TST+/IGRA− and TST−/IGRA+ IGRA+/TST+
vs. IGRA−/TST−
IGRA+/TST− vs. IGRA−/TST− IGRA−/TST+ vs. IGRA−/TST−
No reported contact risk (n = 5833) 15 (0.3%) 136 (2.3%) 26 (0.4%) 5656 (97.0%) 0.15  < 0.001 5.2 Reference Reference Reference
Non-household contact risk (n = 274) 6 (2.2%) 17 (6.2%) 0 (0) 251 (91.6%) 0.39  < 0.001 9.0 (3.5–23.4) 1.0 (0.99–1.0) 2.8 (1.7–4.7)
Household contact risk (n = 95) 4 (4.2%) 13 (13.7%) 1 (1.1%) 77 (81.1%) 0.31  < 0.001 13 19.6 (6.4–60.4) 2.8 (0.4–21.1) 7.0 (3.8–12.9)
  1. TST using 10 mm as a cutoff and IGRA using 8 spots as a cutoff
  2. IGRA interferon-gamma release assay, TST tuberculin skin test, RID respiratory and infectious diseases, OR odds ratio, CI confidence interval