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Table 1 Top 3 most common antibiotic dispensations associated with uncomplicated UTI, ABS and AECOPD events

From: Regional variation in the potentially inappropriate first-line use of fluoroquinolones in Canada as a key to antibiotic stewardship? A drug utilization review study

Province Year Antibiotic dispensations
1 2 3
Uncomplicated UTI
Alberta 2009 Ciprofloxacin Nitrofurantoin tmp/smx
2015 Nitrofurantoin Ciprofloxacin tmp/smx
British Columbia 2005 Ciprofloxacin tmp/smx nitrofurantoin
2015 Nitrofurantoin Ciprofloxacin tmp/smx
Manitoba 2005 tmp/smx Ciprofloxacin Nitrofurantoin
2014 Ciprofloxacin tmp/smx Nitrofurantoin
Nova Scotia 2005 tmp/smx Nitrofurantoin Ciprofloxacin
2015 Nitrofurantoin tmp/smx Ciprofloxacin
Ontario 2005 Nitrofurantoin Norfloxacin tmp/smx
2015 Nitrofurantoin ciprofloxacin tmp/smx
Saskatchewan 2008 Nitrofurantoin tmp/smx Ciprofloxacin
2015 Nitrofurantoin tmp/smx Ciprofloxacin
ABS
Alberta 2009 Amoxicillin Clarithromycin Azithromycin
2015 Amoxicillin Clarithromycin amox/clav
British Columbia 2005 Amoxicillin Clarithromycin Azithromycin
2015 Amoxicillin Clarithromycin amox/clav
Manitoba 2005 Amoxicillin Azithromycin Clarithromycin
2014 Amoxicillin Azithromycin Clarithromycin
Nova Scotia 2005 Amoxicillin Cefuroxime Azithromycin
2015 Amoxicillin amox/clav Cefuroxime
Ontario 2005 Amoxicillin Clarithromycin Azithromycin
2016 Amoxicillin Azithromycin amox/clav
Saskatchewan 2008 Amoxicillin Azithromycin Cephalexin
2015 Amoxicillin Azithromycin Clarithromycin
AECOPD
Alberta 2009 Clarithromycin Levofloxacin Azithromycin
2015 Levofloxacin Azithromycin Doxycycline
British Columbia 2005 Clarithromycin Azithromycin Amoxicillin
2015 Clarithromycin Doxycycline Amoxicillin
Manitoba 2005 Amoxicillin Azithromycin Clarithromycin
2014 Azithromycin Amoxicillin Levofloxacin
Nova Scotia 2005 Azithromycin Amoxicillin Cefuroxime
2015 Doxycycline Amoxicillin Clarithromycin
Ontario 2005 Clarithromycin Azithromycin Levofloxacin
2017 Azithromycin Amoxicillin amox/clav
Saskatchewan 2008 Doxycycline Azithromycin Amoxicillin
2015 Azithromycin Doxycycline Amoxicillin
  1. Data are presented by province at the start and end of study period. Fluoroquinolone antibiotics are in bold
  2. ABS acute bacterial sinusitis, AECOPD acute exacerbation of chronic obstructive pulmonary disease, amox/clav amoxicillin/clavulanic acid, tmp/smx trimethoprim/sulfamethoxazole, UTI urinary tract infection