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Table 2 Changes in Lab findings and efficacy of CP in comparison to other experimental regimes

From: Usefulness of convalescent plasma transfusion for the treatment of severely ill COVID-19 patients in Pakistan

Clinical Lab Parameters COVID-19 Disease Categories         
  Moderate Severe Critical       
Pre CP CI p-value Pre CP CI p-value Pre CP CI p-value  
Post CP Post CP Post CP        
Hematological Parameters (CBC)          
 Hemoglobin g/dl 13.4 ± 1.4 −0.2-1.76 0.112c 12.9 ± 1.5 −0.45-0.88 0.504c 12.4 ± 0.35 −35.7-41.0 5.00c
12.7 ± 1.4 12.7 ± 1.5 9.4 ± 3.9        
 Total Leucocyte count × 109 (TLC) 13.6 ± 6.1 −2.3-5.2 0.425c 13.2 ± 6.3 −1.69-3.09 0.556c 6.9 ± 1.8 −19.7-16.5 0.458c
12.1 ± 4.0 12.5 ± 6.2 8.9 ± 1.9        
 Absolute Neutrophil Count (ANC) 10.5 ± 6.6 −3.5-5.8 0.600c 12.7 ± 14.7 −1.16-9.21 0.124c 45.7 ± 58.3 − 508.2-588.0 0.525c
9.4 ± 4.4 8.7 ± 5.0 5.85 ± 2.6        
 Absolute Lymphocyte Count (ALC) 1.5 ± 1.3 −1.94- -0.4 0.006*c 1.60 ± 1.58 −2.06- -0.29 0.011*c 4.5 ± 4.9 −18.4-23.3 0.376c
2.7 ± 1.1 2.78 ± 1.91 2.0 ± 2.5        
 Platelets Count × 109 227.5 ± 6.3 − 997.9-818.9 0.429c 341 ± 99 −50.0-32.5 0.637c 286.5 ± 164.7 − 585.1-876.1 0.240c
317 ± 94.7 350 ± 9 141.0 ± 83.4        
Biochemistry Markers          
 Alanine aminotransferase
(ALT) U/L
91.0 ± 114 −54.7-186.3 0.220c 30.1 ± 21.9 −14.8-16.8 0.892c 135 ± 1.4 − 155.7-876.1 0.79c
25.1 ± 14.3 29.2 ± 5.6 74.5 ± 12.0        
 Aspartate Aminotransferase
(AST) U/L
97.0 ± 62.0 − 77.3-229.3 0.167c 44.5 ± 23.5 −1.97-17.9 0.084c 128 ± 1.41 − 132.6-70.6 0.161c
21.0 ± 14.9 36.5 ± 18 97.0 ± 9.8        
 Bilirubin mg/dl 0.32 ± 0.95 −0.24- 0.29 0.789c 2.1 ± 5.2 −1.69-4.20 0.362c 0.54 ± 0.21 −0.65-0.74 0.563c
0.30 ± 0.24 0.85 ± 1.11 0.50 ± 0.14        
 Creatinine mg/dl 1.1 ± 0.56 −0.59- 0.59 1.000c 1.07 ± 1.05 −0.17-0.33 0.508c 1.75 ± 1.2 −12.5-10.9 0.536c
1.1 ± 0.59 0.99 ± 1.3 2.5 ± 0.1        
 LDH U/L 404 ± 244 224.1–236.8 0.001*c 450.67 ± 192 − 242.0-822.0 0.144c 250 ± 70.7 − 592-563 0.804c
173 ± 65 160 ± 27 235 ± 6.3        
Inflammatory Markers          
 C-Reactive Protein
(CRP) mg/L
28.1 ± 34.1 2.69–43.2 0.030*c 53.0 ± 91.2 8.17–65.17 0.014*c 159.3 ± 204 − 2813-2778 0.949c
5.1 ± 2.4 16.4 ± 1.3 141.7 ± 107.1        
 Ferritin ng/ml 1000 ± 929 50.8–1404.5 0.038*c 1583 ± 1267 − 311.0-1034.2 0.011*c 768.5 ± 144.9 − 1026-2213 0.135c
272 ± 126 558 ± 93 175.0 ± 35.3        
 D-Dimer ng/ml 1.5 ± 0.45 −2.20-2.07 0.906 c 399.9 ± 460 275.3–1772.9 0.186c 78.0 ± 28.2 − 173.3-309.5 0.173c
1.6 ± 0.64 38.2 ± 7.4 9.9 ± 1.4        
Treatment          
Antibiotics 3 0.064d 29 0.000*d 2 0.500d    
8 13 1        
Corticosteroid 14 0.165d 27 0.195d 2 0.500d    
11 23 1        
  1. cPaired sample t-test
  2. dFisher’s Exact test
  3. *Significant value