Table 2 Changes in Lab findings and efficacy of CP in comparison to other experimental regimes

Moderate

Severe

Critical

Pre CP

CI

p-value

Pre CP

CI

p-value

Pre CP

CI

p-value

Post CP

Post CP

Post CP

Hematological Parameters (CBC)

 Hemoglobin g/dl

13.4 ± 1.4

−0.2-1.76

0.112^c

12.9 ± 1.5

−0.45-0.88

0.504^c

12.4 ± 0.35

−35.7-41.0

5.00^c

12.7 ± 1.4

12.7 ± 1.5

9.4 ± 3.9

 Total Leucocyte count × 10⁹ (TLC)

13.6 ± 6.1

−2.3-5.2

0.425^c

13.2 ± 6.3

−1.69-3.09

0.556^c

6.9 ± 1.8

−19.7-16.5

0.458^c

12.1 ± 4.0

12.5 ± 6.2

8.9 ± 1.9

 Absolute Neutrophil Count (ANC)

10.5 ± 6.6

−3.5-5.8

0.600^c

12.7 ± 14.7

−1.16-9.21

0.124^c

45.7 ± 58.3

− 508.2-588.0

0.525^c

9.4 ± 4.4

8.7 ± 5.0

5.85 ± 2.6

 Absolute Lymphocyte Count (ALC)

1.5 ± 1.3

−1.94- -0.4

0.006^*c

1.60 ± 1.58

−2.06- -0.29

0.011^*c

4.5 ± 4.9

−18.4-23.3

0.376^c

2.7 ± 1.1

2.78 ± 1.91

2.0 ± 2.5

 Platelets Count × 10⁹

227.5 ± 6.3

− 997.9-818.9

0.429^c

341 ± 99

−50.0-32.5

0.637^c

286.5 ± 164.7

− 585.1-876.1

0.240^c

317 ± 94.7

350 ± 9

141.0 ± 83.4

Biochemistry Markers

 Alanine aminotransferase

(ALT) U/L

91.0 ± 114

−54.7-186.3

0.220^c

30.1 ± 21.9

−14.8-16.8

0.892^c

135 ± 1.4

− 155.7-876.1

0.79^c

25.1 ± 14.3

29.2 ± 5.6

74.5 ± 12.0

 Aspartate Aminotransferase

(AST) U/L

97.0 ± 62.0

− 77.3-229.3

0.167^c

44.5 ± 23.5

−1.97-17.9

0.084^c

128 ± 1.41

− 132.6-70.6

0.161^c

21.0 ± 14.9

36.5 ± 18

97.0 ± 9.8

 Bilirubin mg/dl

0.32 ± 0.95

−0.24- 0.29

0.789^c

2.1 ± 5.2

−1.69-4.20

0.362^c

0.54 ± 0.21

−0.65-0.74

0.563^c

0.30 ± 0.24

0.85 ± 1.11

0.50 ± 0.14

 Creatinine mg/dl

1.1 ± 0.56

−0.59- 0.59

1.000^c

1.07 ± 1.05

−0.17-0.33

0.508^c

1.75 ± 1.2

−12.5-10.9

0.536^c

1.1 ± 0.59

0.99 ± 1.3

2.5 ± 0.1

 LDH U/L

404 ± 244

224.1–236.8

0.001^*c

450.67 ± 192

− 242.0-822.0

0.144^c

250 ± 70.7

− 592-563

0.804^c

173 ± 65

160 ± 27

235 ± 6.3

Inflammatory Markers

 C-Reactive Protein

(CRP) mg/L

28.1 ± 34.1

2.69–43.2

0.030^*c

53.0 ± 91.2

8.17–65.17

0.014^*c

159.3 ± 204

− 2813-2778

0.949^c

5.1 ± 2.4

16.4 ± 1.3

141.7 ± 107.1

 Ferritin ng/ml

1000 ± 929

50.8–1404.5

0.038^*c

1583 ± 1267

− 311.0-1034.2

0.011^*c

768.5 ± 144.9

− 1026-2213

0.135^c

272 ± 126

558 ± 93

175.0 ± 35.3

 D-Dimer ng/ml

1.5 ± 0.45

−2.20-2.07

0.906 ^c

399.9 ± 460

275.3–1772.9

0.186^c

78.0 ± 28.2

− 173.3-309.5

0.173^c

1.6 ± 0.64

38.2 ± 7.4

9.9 ± 1.4

Treatment

Antibiotics

3

0.064^d

29

0.000^*d

2

0.500^d

8

13

1

Corticosteroid

14

0.165^d

27

0.195^d

2

0.500^d

11

23

1