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Table 4 Univariable and multivariable analyses of the association between clinical and laboratory variables and death

From: Risk factors for mortality in patients over 70 years old with COVID-19 in Wuhan at the early break: retrospective case series

 

Total n for analysis

Univariable Analysis

HR (95%CI)

P

Multivariable Analysis

HR (95%CI)

P*

Age

147

1.079 (1.027–1.134)

0.003

  

Type

147

    

Severe

42

2.896 (1.473–5.692)

0.002

2.983 (1.231–7.226)

0.016

Critical

16

3.542 (1.515–8.284)

0.004

3.267 (1.009–10.576)

0.048

Leukocytes (109/L)

147

    

< 3.5

13

3.153 (1.251–7.948)

0.015

  

> 9.5

32

3.931 (2.043–7.563)

<  0.001

  

Lymphocytes (109/L)

147

    

< 1.1

100

2.656 (1.179–5.983)

0.018

  

Neutrophils (109/L)

147

    

< 1.8

9

1.289 (0.296–5.611)

0.735

  

> 6.3

48

3.366 (1.786–6.344)

0.001

  

AST (U/L)

147

    

< 15

4

1.180 (0.158–8.831)

0.872

  

> 40

50

2.523 (1.365–4.664)

0.003

  

CK (U/L)

147

    

< 50

50

0.814 (0.395–1.680)

0.578

  

> 310

15

2.990 (1.373–6.511)

0.006

  

Creatinine (μmol/L)

147

    

< 57

37

1.527 (0.715–3.261)

0.274

  

> 111

23

3.987 (1.961–8.103)

0.001

  

BUN (mmol/L)

147

    

< 3.6

7

1.623 (0.378–6.969)

0.515

3.812 (0.788–18.435)

0.096

> 9.5

37

3.913 (2.099–7.291)

<  0.001

2.805 (1.141–6.892)

0.025

Globulin (g/L)

147

    

< 20

12

0.263 (0.036–1.915)

0.187

  

> 40

3

2.042 (0.493–8.468)

0.325

  

Dyspnea

147

1.641 (0.895–3.007)

0.109

  

Hormone therapy

147

2.393 (1.260–4.547)

0.008

  

Antiviral therapy

147

0.188 (0.057–0.615)

0.006

  

Oxygen therapy

147

4.154 (0.571–30.210)

0.160

  

Vasoactive drugs

147

14.126 (7.238–27.569)

< 0.001

16.120 (6.573–39.533)

< 0.001

LDH (U/L)

147

    

> 250

98

5.221 (1.862–14.639)

0.002

  

Procalcitonin (ng/mL)

137

    

> 0.1

64

2.715 (1.405–5.244)

0.003

  

CD3 (/μL)

122

    

< 723

93

9.718 (1.325–71.263)

0.025

  

CD4 (/μL)

122

    

< 404

95

6.496 (1.550–27.232)

0.011

  

CD8 (/μL)

122

    

< 220

85

3.089 (1.081–8.829)

0.035

  

CD19 (/μL)

122

    

< 80

43

1.975 (0.976–3.995)

0.058

  

CD16 + CD56 (/μL)

122

    

< 84

49

2.516 (1.221–5.186)

0.012

  

IgA (g/L)

121

    

> 4.0

19

1.012 (0.388–2.635)

0.981

  

IgM (g/L)

121

    

< 0.4

14

0.946 (0.286–3.126)

0.927

  

> 2.3

3

2.416 (0.573–10.184)

0.230

  

IgE (IU/mL)

121

    

> 100

30

1.541 (0.725–3.272)

0.261

  
  1. *A forward and backward stepwise selection with P values of 0.10 for the forward procedure and 0.05 for the backward procedure was used to select the variables for the final model. AST, aspartate aminotransferase; CK, creatine kinase; LDH, lactate dehydrogenase; BUN, blood urea nitrogen; IgM, immunoglobulin M; IgA, immunoglobulin A; IgE, immunoglobulin E; CD, cluster of differentiation. *P < 0.05