Table 1 Study Characteristics and Pregnancy Rates
Study | Study Treatment | Participating Countries 1 | N females of reproductive potential | N participants reporting one or more pregnancies | Pregnancies (main study) | Pregnancies (Long-term followup) | Pregnancies (total) | rate main | rate ltfu | rate total | Study Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|
HIVNET 026 | canarypox + protein | BR, HT, PE, TT | 60 | 6 | 7 | 0 | 7 | 8.05 | n/a | 8.05 | |
HVTN 039 | canarypox | US | 30 | 0 | 0 | 0 | 0 | 0.00 | n/a | 0.00 | |
HVTN 040 | VEE | ZA, BW, US | 17 | 2 | 2 | 0 | 2 | 13.33 | n/a | 13.33 | |
HVTN 041 | protein | US | 22 | 0 | 0 | 0 | 0 | 0.00 | n/a | 0.00 | |
HVTN 042 | canarypox + lipopeptide | US | 73 | 7 | 8 | 0 | 8 | 4.49 | n/a | 4.49 | |
HVTN 044 | DNA | US | 23 | 1 | 1 | 0 | 1 | 2.70 | n/a | 2.70 | |
HVTN 045 | DNA | US | 20 | 2 | 2 | 0 | 2 | 10.00 | n/a | 10.00 | |
HVTN 048 | DNA | BW, US | 15 | 3 | 3 | 0 | 3 | 14.29 | n/a | 14.29 | |
HVTN 049 | DNA + protein | US | 45 | 2 | 2 | 0 | 2 | 3.77 | n/a | 3.77 | |
HVTN 050 | Ad5 | BR, DR, HT, MW, PE, PR, ZA, TH, US | 162 | 20 | 5 | 21 | 26 | 3.14 | 3.48 | 3.41 | |
HVTN 052 | DNA | US | 76 | 1 | 1 | 0 | 1 | 1.61 | n/a | 1.61 | NCT00071851 |
HVTN 054 | Ad5 | US | 21 | 0 | 0 | 0 | 0 | 0.00 | n/a | 0.00 | |
HVTN 055 | FPV + MVA | BR, US | 74 | 2 | 2 | 0 | 2 | 2.60 | n/a | 2.60 | |
HVTN 056 | peptide | US | 35 | 1 | 1 | 0 | 1 | 2.27 | n/a | 2.27 | |
HVTN 057 | DNA + Ad5 boost | US | 30 | 0 | 0 | 0 | 0 | 0.00 | n/a | 0.00 | NCT00091416 |
HVTN 059 | VEE | BW, ZA, US | 37 | 3 | 3 | 0 | 3 | 8.57 | n/a | 8.57 | |
HVTN 060 | DNA + IL12 DNA + peptide | TH, US | 69 | 3 | 3 | 0 | 3 | 4.11 | n/a | 4.11 | |
HVTN 063 | DNA + IL12 DNA + IL15 DNA | BR, US | 53 | 0 | 0 | 0 | 0 | 0.00 | n/a | 0.00 | |
HVTN 064 | peptide | US | 28 | 1 | 1 | 0 | 1 | 3.70 | n/a | 3.70 | |
HVTN 065 | DNA + MVA | US | 69 | 2 | 2 | 0 | 2 | 2.86 | n/a | 2.86 | |
HVTN 067 | DNA + MVA | US | 15 | 0 | 0 | 0 | 0 | 0.00 | n/a | 0.00 | |
HVTN 068 | DNA + Ad5 | US | 30 | 0 | 0 | 0 | 0 | 0.00 | n/a | 0.00 | |
HVTN 069 | DNA + Ad5 | PE, US | 37 | 5 | 1 | 5 | 6 | 2.70 | 6.17 | 5.08 | |
HVTN 070 | DNA + IL12 DNA | US | 59 | 4 | 4 | 0 | 4 | 7.27 | n/a | 7.27 | |
HVTN 071 | Ad5 | US | 21 | 1 | 1 | 0 | 1 | 4.76 | 0.00 | 1.09 | |
HVTN 072 | DNA + Ad5 + Ad35 | US | 4 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | NCT00472719 |
HVTN 073/E | DNA + MVA + protein | ZA, US | 22 | 2 | 3 | 0 | 3 | 5.45 | 0.00 | 5.00 | |
HVTN 076 | DNA + Ad5 | US | 6 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | NCT00955006 |
HVTN 077 | DNA + Ad5 + Ad35 | US | 81 | 5 | 1 | 6 | 7 | 1.30 | 2.10 | 1.93 | |
HVTN 078 | attenuated vaccinia + Ad5 | CH | 57 | 1 | 1 | 0 | 1 | 1.45 | n/a | 1.45 | |
HVTN 080 | DNA + IL12 DNA | US | 27 | 0 | 0 | 0 | 0 | 0.00 | n/a | 0.00 | |
HVTN 082 | DNA + Ad5 | US | 8 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | NCT01054872 |
HVTN 083 | Ad5 | US | 78 | 4 | 1 | 4 | 5 | 1.75 | 1.20 | 1.28 | |
HVTN 084 | Ad5 | BR, PE, CH, US | 82 | 16 | 0 | 19 | 19 | 0.00 | 5.18 | 4.70 | |
HVTN 085 | Ad5 | US | 37 | 4 | 0 | 4 | 4 | 0.00 | 2.35 | 2.11 | NCT01479296 |
HVTN 086 | DNA + MVA + protein | ZA | 95 | 9 | 2 | 7 | 9 | 2.17 | 3.32 | 2.97 | |
HVTN 087 | DNA + IL12 DNA + VSV | US | 35 | 1 | 0 | 1 | 1 | 0.00 | 3.85 | 1.49 | |
HVTN 088 | protein | US | 13 | 2 | 2 | 0 | 2 | 7.41 | n/a | 7.41 | |
HVTN 090 | VSV | US | 29 | 5 | 0 | 6 | 6 | 0.00 | 7.89 | 6.45 | |
HVTN 092 | DNA + attenuated vaccinia | CH, US | 76 | 2 | 2 | 0 | 2 | 3.64 | 0.00 | 3.03 | NCT01783977 |
HVTN 094 | DNA + MVA | US | 30 | 3 | 1 | 2 | 3 | 2.27 | 6.45 | 4.00 | |
HVTN 096 | DNA + attenuated vaccinia + protein | CH | 49 | 10 | 3 | 9 | 12 | 4.35 | 3.95 | 4.04 | |
HVTN 097 | canarypox + protein | ZA | 49 | 2 | 2 | 0 | 2 | 3.85 | n/a | 3.85 | |
HVTN 098 | DNA + IL12 DNA | US | 40 | 1 | 1 | 0 | 1 | 1.75 | n/a | 1.75 | NCT02431767 |
HVTN 100 | canarypox + protein | ZA | 109 | 4 | 4 | 0 | 4 | 1.82 | n/a | 1.82 | |
HVTN 105 | DNA + protein | US | 48 | 0 | 0 | 0 | 0 | 0.00 | n/a | 0.00 | |
HVTN 106 | DNA + MVA | CH, US | 44 | 2 | 2 | 0 | 2 | 4.08 | n/a | 4.08 | NCT02296541 |
HVTN 110 | Ad4 + protein | US | 4 | 0 | 0 | 0 | 0 | 0.00 | n/a | 0.00 | NCT02771730 |
HVTN 111 | DNA + protein | ZA, TZ, ZM | 65 | 1 | 1 | 0 | 1 | 1.59 | n/a | 1.59 | |
HVTN 112 | DNA + VSV | US | 5 | 0 | 0 | 0 | 0 | 0.00 | n/a | 0.00 | NCT02654080 |
HVTN 203 | canarypox + protein | US | 81 | 4 | 5 | 0 | 5 | 4.24 | n/a | 4.24 | |
HVTN 204 | DNA + Ad5 | BR, HT, JM, ZA, US | 254 | 18 | 18 | 0 | 18 | 3.01 | n/a | 3.01 | |
HVTN 205 | DNA + MVA | PE, US | 124 | 10 | 5 | 6 | 11 | 4.17 | 2.80 | 3.29 | |
Total | Â | Â | 2673 | 172 | 103 | 90 | 193 | 3.09 | 3.22 | 3.15 | Â |