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Table 3 Univariable and multivariable odds ratios (OR) with 95% confidence intervals (CI) for invasive pneumococcal disease with non-vaccine serotypes in relation to patient derived factors in Southwest Sweden between 2009 and 2015

From: Invasive pneumococcal disease in persons with predisposing factors is dominated by non-vaccine serotypes in Southwest Sweden

  Odds ratio (OR) with 95% confidence interval (CI)
  Univariable analysis Multivariable analysis  
Variable Non-PCV10 serotypes, n = 858 p Non-PCV13 serotypes, n = 635 p Non-PPV23 serotypes, n = 264 p Non-PCV10 serotypes, n = 858 p Non-PCV13 serotypes, n = 635 p Non-PPV23 serotypes, n = 264 p
Age (by 10 years) 1.12 (1.06–1.19) < 0.0001 1.09 (1.03–1.15) 0.002 1.12 (1.04–1.20) 0.002 1.01 (1.00–1.02) 0.001    1.01 (1.01–1.02) 0.006
Men, n = 668 0.96 (0.76–1.21) 0.77 0.98 (0.79–1.22) 0.89 1.05 (0.81–1.39) 0.70       
Predisposing factor, any, n = 1051 1.66 (1.26–2.22) 0.0003 1.79 (1.35–2.38) < 0.0001 1.35 (0.93–1.92) 0.11 1.47 (1.10–1.96) 0.01 1.52 (1.14–2.04) 0.005   
Current or previous smoking, n = 528 0.91 (0.72–1.14) 0.45 1.02 (0.82–1.28) 0.83 0.77 (0.58–1.02) 0.07       
Cardiovascular disease, n = 379 1.56 (1.19–2.00) 0.001 1.30 (1.02–1.64) 0.03 1.32 (0.99–1.75) 0.06       
Malignancy, n = 271 1.36 (1.02–1.81) 0.04 1.56 (1.19–2.04) 0.001 1.79 (1.32–2.44) 0.0002    1.37 (1.04–1.82) 0.03 1.61 (1.18–2.22) 0.003
Pulmonary disease, n = 267 1.19 (0.89–1.58) 0.23 1.04 (0.79–1.35) 0.79 1.09 (0.78–1.52) 0.62       
Diabetes mellitus, n = 195 1.04 (0.75–1.44) 0.78 1.08 (0.79–1.45) 0.64 0.94 (0.65–1.39) 0.78       
Immunsuppressive treatment, n = 170 1.06 (0.75–1.49) 0.71 1.18 (0.85–1.64) 0.31 1.30 (0.88–1.89) 0.18       
Substance abuse, n = 116 0.86 (0.58–1.29) 0.50 0.78 (0.53–1.15) 0.21 0.65 (0.38–1.11) 0.12       
Autoimmunity, n = 106 0.88 (0.58–1.33) 0.56 1.02 (0.68–1.52) 0.94 1.32 (0.83–2.08) 0.25       
Liver disease, n = 64 1.47 (0.82–2.56) 0.19 1.12 (0.68–1.85) 0.64 1.33 (0.75–2.38) 0.33       
Immune deficiency, n = 63 1.85 (1.02–3.44) 0.04 2.56 (1.47–4.35) 0.0009 2.22 (1.30–3.85) 0.003    2.17 (1.23–3.70) 0.007 2.13 (1.23–3.70) 0.007
Renal disease, n = 63 1.85 (1.02–3.44) 0.04 2.17 (1.28–3.70) 0.004 1.37 (0.76–2.44) 0.30    1.96 (1.15–3.33) 0.01   
  1. The statistical calculations were performed by comparing non-PCV10 serotypes versus all serotypes, non-PCV13 serotypes versus all serotypes and non-PPV23 serotypes versus all serotypes, respectively