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Table 2 The distribution of vaccine and non-vaccine pneumococcal serotypes in relation to clinical factors in patients with invasive pneumococcal disease in Southwest Sweden between 2009 and 2015

From: Invasive pneumococcal disease in persons with predisposing factors is dominated by non-vaccine serotypes in Southwest Sweden

   Clinical characteristics
Serotype Number of strains n (%) Median age (y) Predisposing factorsa n (%) Meningitis# n (%) Pneumonia# n (%) Bacteremia with unknown focus n (%) Other manifestationb n (%) Admitted to the intensive care unit n (%) Case fatality ratec n (%)
PCV10d 446 (34) 65 335 (75)*** 26 (6) 366 (82)*** 32 (7)*** 23 (5) 94 (21) 38 (9)**
Non-PCV10 858 (66) 71 716 (83) 76 (9) 577 (67) 141 (16) 67 (8) 208 (24) 127 (15)
PCV13e 669 (51) 67 510 (76)*** 46 (7) 534 (80)*** 58 (9)*** 32 (5)** 167 (25) 77 (12)
Non-PCV13 635 (49) 71 541 (85) 56 (9) 409 (64) 115 (18) 58 (9) 135 (21) 88 (14)
PPV23f 1040 (80) 68 829 (80) 77 (7) 788 (76)*** 110 (11)*** 69 (7) 241 (23) 124 (12)
Non-PPV23 264 (20) 74 222 (84) 25 (9) 155 (59) 63 (24) 21 (8) 61 (23) 41 (16)
Total 1304 69 1051 (81) 102 (8) 943 (72) 173 (13) 90 (7) 302 (23) 165 (13)
  1. The statistical calculations were performed by comparing PCV10 serotypes versus non-PCV10 serotypes, PCV13 serotypes versus non-PCV13 serotypes and PPV23 serotypes versus non-PPV23 serotypes, respectively
  2. * p < 0.05, ** p < 0.01, *** p < 0.001
  3. # There were five episodes of both pneumonia and meningitis. These were included in the analysis of each of the manifestations
  4. a Smoking, cardiovascular disease, malignancy, pulmonary disease, diabetes mellitus, immunosuppressive treatment, substance abuse, autoimmunity, liver disease, immune deficiency, renal disease and asplenia
  5. bAbscess, appendicitis, bronchitis, cholangitis, endocarditis, epidural abscess, epiglottitis, mastoiditis, osteitis, otitis media, pharyngitis, peritonitis, prosthetic joint infection, septic arthritis, skin and soft tissue infection, sinusitis and uteritis
  6. cDeath within 30 days of positive culture for pneumococci
  7. dIncluding serotype 1, 4, 5, 6B, 7F, 9 V, 14, 18C, 19F and 23F
  8. eIncluding serotype 1, 3, 4, 5, 6A, 6B, 7F, 9 V, 14, 18C, 19A, 19F and 23F
  9. fIncluding serotype 1, 2, 3, 4, 5, 6B, 7F, 8, 9 N, 9 V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F and 33F