| | |
Clinical characteristics
|
|---|
|
Serotype
|
Number of strains n (%)
|
Median age (y)
|
Predisposing factorsa n (%)
|
Meningitis# n (%)
|
Pneumonia# n (%)
|
Bacteremia with unknown focus n (%)
|
Other manifestationb n (%)
|
Admitted to the intensive care unit n (%)
|
Case fatality ratec n (%)
|
|---|
|
PCV10d
|
446 (34)
|
65
|
335 (75)***
|
26 (6)
|
366 (82)***
|
32 (7)***
|
23 (5)
|
94 (21)
|
38 (9)**
|
|
Non-PCV10
|
858 (66)
|
71
|
716 (83)
|
76 (9)
|
577 (67)
|
141 (16)
|
67 (8)
|
208 (24)
|
127 (15)
|
|
PCV13e
|
669 (51)
|
67
|
510 (76)***
|
46 (7)
|
534 (80)***
|
58 (9)***
|
32 (5)**
|
167 (25)
|
77 (12)
|
|
Non-PCV13
|
635 (49)
|
71
|
541 (85)
|
56 (9)
|
409 (64)
|
115 (18)
|
58 (9)
|
135 (21)
|
88 (14)
|
|
PPV23f
|
1040 (80)
|
68
|
829 (80)
|
77 (7)
|
788 (76)***
|
110 (11)***
|
69 (7)
|
241 (23)
|
124 (12)
|
|
Non-PPV23
|
264 (20)
|
74
|
222 (84)
|
25 (9)
|
155 (59)
|
63 (24)
|
21 (8)
|
61 (23)
|
41 (16)
|
|
Total
|
1304
|
69
|
1051 (81)
|
102 (8)
|
943 (72)
|
173 (13)
|
90 (7)
|
302 (23)
|
165 (13)
|
- The statistical calculations were performed by comparing PCV10 serotypes versus non-PCV10 serotypes, PCV13 serotypes versus non-PCV13 serotypes and PPV23 serotypes versus non-PPV23 serotypes, respectively
- * p < 0.05, ** p < 0.01, *** p < 0.001
- # There were five episodes of both pneumonia and meningitis. These were included in the analysis of each of the manifestations
- a Smoking, cardiovascular disease, malignancy, pulmonary disease, diabetes mellitus, immunosuppressive treatment, substance abuse, autoimmunity, liver disease, immune deficiency, renal disease and asplenia
- bAbscess, appendicitis, bronchitis, cholangitis, endocarditis, epidural abscess, epiglottitis, mastoiditis, osteitis, otitis media, pharyngitis, peritonitis, prosthetic joint infection, septic arthritis, skin and soft tissue infection, sinusitis and uteritis
- cDeath within 30 days of positive culture for pneumococci
- dIncluding serotype 1, 4, 5, 6B, 7F, 9 V, 14, 18C, 19F and 23F
- eIncluding serotype 1, 3, 4, 5, 6A, 6B, 7F, 9 V, 14, 18C, 19A, 19F and 23F
- fIncluding serotype 1, 2, 3, 4, 5, 6B, 7F, 8, 9 N, 9 V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F and 33F
