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Table 1 Univariate analyses of baseline characteristics of HIV/CM inpatients in the derivative cohort

From: Establishment of a novel scoring model for mortality risk prediction in HIV-infected patients with cryptococcal meningitis

Variable Survivors Non-survivors p-value
(n = 328) (n = 58)
Demographic characteristics
 Age (years, IQR) 43(34,52) 54(44.8,65) < 0.0001
 Male sex, n (%) 263 (80.2%) 40 (69.0%) 0.055
Comorbidity and Complications
 Cerebral infarction, n (%) 14 (4.3%) 5 (8.6%) 0.182#
 Liver cirrhosis, n (%) 5 (1.5%) 2 (3.4%) 0.284#
 Diabetes, n (%) 17 (5.2%) 5 (8.6%) 0.351#
 Tuberculosis, n (%) 47 (14.3%) 12 (20.7%) 0.215
 Pneumocystis pneumonia, n (%) 30 (9.1%) 6 (10.3%) 0.772
 Bacterial pneumonia, n (%) 48 (14.6%) 13 (22.4%) 0.134
 Cytomegalovirus infection 34 (10.4%) 7 (12.1%) 0.698
Clinical characteristic
 Time from symptom onset to hospital admission (month, IQR) 0.7(0.3,1.0) 1(0.3,2.0) 0.287
 Maximum body temperature (°C, IQR) 37.8 (36.7,39.0) 36.6 (36.7,38.3) 0.213
 Stiff neck, n (%) 24 (7.3%) 17 (29.3%) < 0.0001
 Impaired consciousness, n (%) 28 (8.5%) 22 (37.9%) < 0.0001
 Headache, n (%) 243 (74.1%) 45(77.6%) 0.572
 Seizures, n (%) 25 (7.6%) 7 (12.1%) 0.298#
 Weight loss, n (%) 125 (38.1%) 29 (50.0%) 0.088
Laboratory data
 CSF glucose (mmol/L, IQR) 2.54 (1.9,3.2) 2.25 (1.2,3.1) 0.045
 Neutrophil count (109/L, IQR) 3.4 (2.3,5.4) 3.8 (2.1,6.3) 0.419
 TBIL (μmol/L, IQR) 9.2 (7.0,13.6) 13.5 (9.0,19.7) < 0.0001
 HGB (g/L, IQR) 115.0 (98.0,130.0) 108.0 (94.3126.0) 0.235
 PLT (×  106 /L, IQR) 186 (126.0,248.8) 120 (82,202) < 0.0001
 Urea (mmol/L, IQR) 3.8 (3.0,5.5) 4.9 (3.7,6.8) 0.001
 Creatinine (μmol/L, IQR) 59.1 (49.0,71.2) 60.3 (49.1,75.6) 0.787
 White blood cell count (109/L, IQR) 4.6 (3.4,6.5) 4.7(3.1,7.2) 0.939
 CD4+ T-cell count (cells/μL, IQR) 32.0 (13.0,77.3) 29.0 (12.8,48.0) 0.095
 HIV RNA (log10 copies/mL, IQR) 5.1 (3.9,5.7) 5.4 (4.9,5.9) 0.009
 ICP (mm H2O, IQR) 215.0 (160.0,328.0) 360.0 (247.0,400.0) < 0.0001
 ART at hospital admission, n (%) 198 (51.3%) 27(46.6%) 0.500
  1. Abbreviations: CSF cerebrospinal fluid, HGB hemoglobin, ICP intracranial pressure, TBIL total bilirubin, PLT platelet, ART antiviral therapy; p < 0.05 was considered statistically significant. # indicates the factors were calculated by the Fisher exact test, otherwise they were calculated by Pearson’s χ2 test