Table 4 Univariate analysis of covariates associated with mortality in patients with primary hemophagocytic lymphohistiocytosis
Variables | Mean survival in days (95% confidence interval) | P-value |
|---|---|---|
Splenomegaly | ||
 Yes | 935.9 (678.5-1193.4) | 0.069 |
 No | 37 (1.72-72.3) | |
BM. hemophagocytosis | ||
 Yes | 146.0 (24.9-267.1) | 0.059 |
 No | 977.2 (710.2-1244.2) | |
CNS involvement | ||
 Yes | 655.6 (304.0-1007.0) | 0.092 |
 No | 849.3 (657.7-1040.9) | |
Bleeding tendency | ||
 Yes | 195.8 (24.5-367.1) | 0.059 |
 No | 960.1 (695.9-1224.2) | |
Bicytopenia | ||
 Yes | 801.7 (540.0-1063.4) | 0.052 |
 No | 845.2 (652.5-1037.8) | |
Platelet count | ||
 <100,000/μL | 711.2 (443.8-978.7) | 0.001* |
 ≥ 100,000/μL | 1195.2 (1001.1-1389.3) | |
Hemoglobin | ||
 < 9 g/dL | 844.0 (562.9-1125.2) | 0.188 |
 ≥ 9 g/dL | 808.1 (547.3-1068.9) | |
Total bilirubin | ||
  > 1 mg/dL | 571.2 (275.5-867.0) | 0.008* |
  ≤ 1 mg/dL | 1004.3 (781.7-1226.8) | |
ESR | ||
 > 20 mm/hr | 1271.7 (934.8-1608.6) | 0.002* |
 ≤ 20 mm/hr | 459.4 (298.7-620.1) | |
Fibrinogen | ||
 < 150 mg/dL | 1001.8 (660.1- 1343.5) | 0.183 |
 ≥ 150 mg/dL | 658.7 (405.4-912.1) | |