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Table 4 Univariate analysis of covariates associated with mortality in patients with primary hemophagocytic lymphohistiocytosis

From: Comparison of the clinical features and outcome of children with hemophagocytic lymphohistiocytosis (HLH) secondary to visceral leishmaniasis and primary HLH: a single-center study

Variables Mean survival in days
(95% confidence interval)
P-value
Splenomegaly
 Yes 935.9 (678.5-1193.4) 0.069
 No 37 (1.72-72.3)
BM. hemophagocytosis
 Yes 146.0 (24.9-267.1) 0.059
 No 977.2 (710.2-1244.2)
CNS involvement
 Yes 655.6 (304.0-1007.0) 0.092
 No 849.3 (657.7-1040.9)
Bleeding tendency
 Yes 195.8 (24.5-367.1) 0.059
 No 960.1 (695.9-1224.2)
Bicytopenia
 Yes 801.7 (540.0-1063.4) 0.052
 No 845.2 (652.5-1037.8)
Platelet count
 <100,000/μL 711.2 (443.8-978.7) 0.001*
 ≥ 100,000/μL 1195.2 (1001.1-1389.3)
Hemoglobin
 < 9 g/dL 844.0 (562.9-1125.2) 0.188
 ≥ 9 g/dL 808.1 (547.3-1068.9)
Total bilirubin
  > 1 mg/dL 571.2 (275.5-867.0) 0.008*
  ≤ 1 mg/dL 1004.3 (781.7-1226.8)
ESR
 > 20 mm/hr 1271.7 (934.8-1608.6) 0.002*
 ≤ 20 mm/hr 459.4 (298.7-620.1)
Fibrinogen
 < 150 mg/dL 1001.8 (660.1- 1343.5) 0.183
 ≥ 150 mg/dL 658.7 (405.4-912.1)
  1. ULN upper limit of normal, ALT alanine aminotransferase, ESR Erythrocyte sedimentation rate, CNS central nervous system, BM bone marrow
  2. †The data were analyzed by the Log-rank test; only variables with P < 0.2 are shown
  3. *Statistically significant