CNS involvement | Total | P-Value | Primary HLH | P-Value | VL-associated HLH | P-Value | |||
---|---|---|---|---|---|---|---|---|---|
Variables | Yes (n = 23) n (%) | No (n = 37) n (%) |  | Yes (n = 18) | No (n = 22) |  | Yes (n = 5) | No (n = 15) |  |
Age | |||||||||
 <24 months | 20 (87) | 22 (59.5) | 0.024* | 16 (88.9) | 11 (50) | 0.016* | 4 (80) | 11 (73.3) | > 0.999 |
 ≥ 24 months | 3 (13) | 15 (40.5) | 2 (11.1) | 11 (50) | 1 (20) | 4 (26.7) | |||
Sex | |||||||||
 Male | 16 (69.6) | 18 (48.6) | 0.112 | 14 (77.8) | 10 (45.5) | 0.054 | 2 (40) | 8 (53.3) | > 0.999 |
 Female | 7 (30.4) | 19 (51.4) | 4 (22.2) | 12 (54.5) | 3 (60) | 7 (46.7) | |||
Platelet <100000/μl | 18 (78.3) | 22 (59.5) | 0.133 | 15 (83.3) | 16 (72.7) | 0.476 | 3 (60) | 6 (40) | 0.617 |
Bicytopenia | 22 (95.7) | 26 (70.3) | 0.020* | 17 (94.4) | 17 (77.3) | 0.197 | 5 (100) | 9 (60) | 0.260 |
Fibrinogen <150 mg/dL | 9 (39.1) | 23 (62.2) | 0.082 | 7 (38.9) | 13 (59.1) | 0.341 | 2 (40) | 10 (66.7) | 0.347 |
ALT>2 × ULN (IU/L) | 12 (52.2) | 13 (35.1) | 0.193 | 12 (66.7) | 9 (40.9) | 0.125 | 0 (0) | 4 (26.7) | 0.530 |
BM. hemophagocytosis | 5 (21.7) | 1 (2.7) | 0.027* | 5 (27.8) | 1 (4.5) | 0.073 | 0 (0) | 0 (0) | – |
Bleeding tendency | 4 (17.4) | 1 (2.7) | 0.066 | 4 (22.2) | 1 (4.5) | 0.155 | 0 (0) | 0 (0) | – |