Comparison of the clinical features and outcome of children with hemophagocytic lymphohistiocytosis (HLH) secondary to visceral leishmaniasis and primary HLH: a single-center study

Table 1 HScore

Parameter	Score
Known underlying immunosuppression¸ HIV positive, Immunosuppressive drugs
No	0
Yes	18
Maximal temperature (C)
< 38.4	0
38.4–39.4	33
> 39.4	49
Organomegaly
No	0
Hepatomegaly or splenomegaly	23
Hepatomegaly & splenomegaly	38
Number of cytopenias (Hb ≤ 9.2 g/dL, WBC ≤ 5000/μl, PLT ≤ 110,000/μl)
1 lineage	0
2 lineages	24
3 lineages	34
Higher ferritin level (ng/ml)
< 2000	0
2000–6000	35
> 6000	50
Higher triglyceride level (mg/dL)
< 133.5	0
133.5–356	44
> 356	64
Lower fibrinogen level (g/L)
> 250	0
≤ 250	30
Higher SGOT/AST level (IU/L)
< 30	0
≥ 30	19
Hemophagocytosis features on bone marrow aspirate
No	0
Yes	35
Total score

HIV human immunodeficiency virus, Hb hemoglobin, WBC white blood cell, PLT platelet, SGOT serum glutamic-oxaloacetic transaminase, AST aspartate aminotransferase

ISSN: 1471-2334