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Table 1 HScore

From: Comparison of the clinical features and outcome of children with hemophagocytic lymphohistiocytosis (HLH) secondary to visceral leishmaniasis and primary HLH: a single-center study

Parameter Score
Known underlying immunosuppression¸ HIV positive, Immunosuppressive drugs
 No 0
 Yes 18
Maximal temperature (C)
  < 38.4 0
 38.4–39.4 33
  > 39.4 49
Organomegaly
 No 0
 Hepatomegaly or splenomegaly 23
 Hepatomegaly & splenomegaly 38
Number of cytopenias (Hb ≤ 9.2 g/dL, WBC ≤ 5000/μl, PLT ≤ 110,000/μl)
 1 lineage 0
 2 lineages 24
 3 lineages 34
Higher ferritin level (ng/ml)
  < 2000 0
 2000–6000 35
  > 6000 50
Higher triglyceride level (mg/dL)
  < 133.5 0
 133.5–356 44
  > 356 64
Lower fibrinogen level (g/L)
  > 250 0
  ≤ 250 30
Higher SGOT/AST level (IU/L)
  < 30 0
  ≥ 30 19
Hemophagocytosis features on bone marrow aspirate
 No 0
 Yes 35
Total score
  1. HIV human immunodeficiency virus, Hb hemoglobin, WBC white blood cell, PLT platelet, SGOT serum glutamic-oxaloacetic transaminase, AST aspartate aminotransferase