Fig. 2

Genetic profiling of 347 M. tuberculosis strains from Guangxi, China. Phylogenetic tree reconstructed by maximum-likelihood algorithm using 26870 single-nucleotide polymorphism sites. Heatmap employing a cool-to-warm (value from 0 to 1) color scheme to represent the heterozygosity of every haploid genome. Heterozygosity of problematic leaf-nodes that have branch length and topological variation is high. Outer circles of heatmap marked drug resistance detected by in silico method. Lineage-specific genetic markers labeled in the inner circles used color squares. Dots that denote the leaf-nodes are corresponding to color dots in Fig. 1. And potential local circling clusters are highlighted in yellow