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Fig. 2 | BMC Infectious Diseases

Fig. 2

From: Identification of novel genes involved in apoptosis of HIV-infected macrophages using unbiased genome-wide screening

Fig. 2

Genome-wide screening of HIV-infected and uninfected macrophages. A Schematic representation of the genome-wide screen. B Volcano plot representing the hits from the screening. The X-axis represents the fitness score and the Y-axis represents the p-value significance. Magenta color dots represent the final selected hits while the dark yellow represents all the significant hits from the screen. C Precision-Recall curve evaluating quality of the screen as described in Hart et al. 2013 (PMID: 24987113). Higher the F-measure, lower is the error rate. Usually, F > 0.5 provides a reliable screen. D Cytoscape representation of the hits from the screen. Since U937 and U1 cells were differentiated during the screening, the key nodes are arranged such that the hits prior to differentiation (T0-T6) and after differentiation (T6-T12) are presented in the context of overall hits. Nodes with gene names are those that were picked up in all possible conditions

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