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Table 2 CLSI Breakpoints for Select Penicillin and Cephalosporins [7]

From: Predicting Oral Beta-lactam susceptibilities against Streptococcus pneumoniae

  Interpretative Categories and MIC Breakpoints (μg/ml)
Antimicrobial Agent Susceptible Intermediate Resistant
Penicillin (meningitis) ≤ 0.06 ≥ 0.12
Penicillin (non-meningitis) ≤ 2 4 ≥ 8
Amoxicillin ≤ 2 4 ≥ 8
Cefotaxime (meningitis) ≤ 0.5 1 ≥ 2
Cefotaxime (non-meningitis) ≤ 1 2 ≥ 4
Cefuroxime (oral) ≤ 1 2 ≥ 4
Cefdinir ≤ 0.5 1 ≥ 2
Cefpodoxime ≤ 0.5 1 ≥ 2