Fig. 3

Associations between clinical characteristics and serum cytokine levels of acute CHIKV and DENV-infected patients. (A) Spearman analysis was used to test correlations between serum cytokine level and age, duration of fever, leukocyte count, and platelet count. Bars represent correlation coefficient (r) value with colours indicating statistical significance. (B) Comparison of IL-4, IL-5, IL-13, MCP-3, and eotaxin serum levels among different age groups between CHIKV and DENV-infected patients. Assay detection sensitivity limits are indicated by the grey dashed line. (C) Comparison of IL-8 serum levels between thrombocytopenic (platelet count < 150,000 cells/μl) and non-thrombocytopenic groups. In (B) and (C), each dot represents the cytokine concentration of an individual. Bars or horizontal lines indicate group median. Black asterisks represent statistical significance by the Mann-Whitney test (*P < 0.05, ***P < 0.001)