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Table 2 GRADE Summary of Findings

From: Symptomatic treatment (using NSAIDS) versus antibiotics in uncomplicated lower urinary tract infection: a meta-analysis and systematic review of randomized controlled trials

Non-steroidal anti-inflammatory drugs compared to antibiotics for uncomplicated acute urinary tract infection
Patients or population: Non-pregnant women aged > 18 yrs. old with acute uncomplicated lower urinary tract infection
Settings: Community-based
Intervention: Non-steroidal anti-inflammatory drugs
Comparison: Antibiotics
Certainty assessment № of patients Effect Certainty Importance
№ of studies Study design Risk of bias Inconsistency Indirectness Imprecision Other considerations non-steroidal anti-inflammatory drugs antibiotics Relative
(95% CI)
Absolute
(95% CI)
Symptom resolution by Day 3 or 4
1144 randomised trials not serious serious not serious not serious none 254/584 (43.5%) 373/560 (66.6%) RR 0.69
(0.55 to 0.86)
206 fewer per 1000
(from 300 fewer to 93 fewer)

MODERATE
CRITICAL
Complication of upper urinary tract infection
1096 randomised trials serious not serious not serious not serious none 26/555 (4.7%) 1/541 (0.2%) OR 6.49
(3.02 to 13.92)
10 more per 1000
(from 4 more to 23 more)

MODERATE
CRITICAL
Positive urine culture post-treatment
681 randomised trials serious not serious not serious not serious none 100/350 (28.6%) 34/331 (10.3%) RR 2.77
(1.95 to 3.94)
182 more per 1000
(from 98 more to 302 more)

MODERATE
IMPORTANT
Use of rescue or secondary antibiotic
1165 randomised trials serious serious not serious not serious none 243/591 (41.1%) 72/574 (12.5%) RR 3.16
(2.24 to 4.44)
271 more per 1000
(from 156 more to 431 more)

LOW
IMPORTANT
  1. CI Confidence interval; RR Risk ratio; OR Odds ratio