Table 2 GRADE Summary of Findings
Non-steroidal anti-inflammatory drugs compared to antibiotics for uncomplicated acute urinary tract infection | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patients or population: Non-pregnant women aged > 18 yrs. old with acute uncomplicated lower urinary tract infection | ||||||||||||
Settings: Community-based | ||||||||||||
Intervention: Non-steroidal anti-inflammatory drugs | ||||||||||||
Comparison: Antibiotics | ||||||||||||
Certainty assessment | № of patients | Effect | Certainty | Importance | ||||||||
№ of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | non-steroidal anti-inflammatory drugs | antibiotics | Relative (95% CI) | Absolute (95% CI) | ||
Symptom resolution by Day 3 or 4 | ||||||||||||
1144 | randomised trials | not serious | serious | not serious | not serious | none | 254/584 (43.5%) | 373/560 (66.6%) | RR 0.69 (0.55 to 0.86) | 206 fewer per 1000 (from 300 fewer to 93 fewer) | ⨁⨁⨁◯ MODERATE | CRITICAL |
Complication of upper urinary tract infection | ||||||||||||
1096 | randomised trials | serious | not serious | not serious | not serious | none | 26/555 (4.7%) | 1/541 (0.2%) | OR 6.49 (3.02 to 13.92) | 10 more per 1000 (from 4 more to 23 more) | ⨁⨁⨁◯ MODERATE | CRITICAL |
Positive urine culture post-treatment | ||||||||||||
681 | randomised trials | serious | not serious | not serious | not serious | none | 100/350 (28.6%) | 34/331 (10.3%) | RR 2.77 (1.95 to 3.94) | 182 more per 1000 (from 98 more to 302 more) | ⨁⨁⨁◯ MODERATE | IMPORTANT |
Use of rescue or secondary antibiotic | ||||||||||||
1165 | randomised trials | serious | serious | not serious | not serious | none | 243/591 (41.1%) | 72/574 (12.5%) | RR 3.16 (2.24 to 4.44) | 271 more per 1000 (from 156 more to 431 more) | ⨁⨁◯◯ LOW | IMPORTANT |