LAMP WITH MODIFIED BOOM DNA EXTRACTS | |||||||||
BURULI Primers | MU 2404 Primers | BU-LAMP Primers | |||||||
(+) | (−) | Total | (+) | (−) | Total | (+) | (−) | Total | |
IS2404 PCR (+) | 86 | 8 | 94 | 81 | 13 | 94 | 54 | 40 | 94 |
IS2404 PCR (−) | 1 | 41 | 42 | 5 | 37 | 42 | 0 | 42 | 42 |
Total | 87 | 49 | 136 | 86 | 50 | 136 | 54 | 82 | 136 |
Disease prevalence | 69.12% (60.63 to 76.75%) | 69.12% (60.63 to 76.75%) | 69.12% (60.63 to 76.75%) | ||||||
Sensitivity | 91.49% (83.92 to 96.25%) | 86.17% (77.51 to 92.43%) | 57.45% (46.82 to 67.59%) | ||||||
Specificity | 97.62% (87.43 to 99.94%) | 88.10% (74.37 to 96.02%) | 100.00% (91.59 to 100.00%) | ||||||
Positive Predictive Value | 98.85% (92.53 to 99.83%) | 94.19% (87.64 to 97.37%) | 100% | ||||||
Negative Predictive Value | 83.67% (72.50 to 90.88%) | 74.00% (62.93 to 82.67%) | 51.22% (45.36 to 57.04%) | ||||||
Accuracy | 93.38% (87.81 to 96.93%) | 86.76% (79.89 to 91.96%) | 70.59% (62.17 to 78.09%) | ||||||
LAMP WITH EasyNAT DNA EXTRACTS | |||||||||
BURULI Primers | MU 2404 Primers | BU-LAMP Primers | |||||||
(+) | (−) | Total | (+) | (−) | Total | (+) | (−) | Total | |
IS2404 PCR (+) | 70 | 10 | 80 | 59 | 21 | 80 | 38 | 42 | 80 |
IS2404 PCR (−) | 0 | 56 | 56 | 1 | 55 | 56 | 1 | 55 | 56 |
Total | 70 | 66 | 136 | 60 | 76 | 136 | 39 | 97 | 136 |
Disease prevalence | 58.82% (50.07 to 67.19%) | 58.82% (50.07 to 67.19%) | 58.82% (50.07 to 67.19%) | ||||||
Sensitivity | 87.50% (78.21 to 93.84%) | 73.75% (62.71 to 82.96%) | 47.50% (36.21 to 58.98%) | ||||||
Specificity | 100.00% (93.62 to 100.00%) | 98.21% (90.45 to 99.95%) | 98.21% (90.45 to 99.95%) | ||||||
Positive Predictive Value | 100% | 98.33% (89.39 to 99.76%) | 97.44% (84.31 to 99.63%) | ||||||
Negative Predictive Value | 84.85% (75.82 to 90.91%) | 72.37% (64.42 to 79.11%) | 56.70% (51.46 to 61.80%) | ||||||
Accuracy | 92.65% (86.89 to 96.42%) | 83.82% (76.54 to 89.58%) | 68.38% (59.86 to 76.08%) | ||||||
LAMP WITH MODIFIED EasyNAT DNA EXTRACTS | |||||||||
BURULI Primers | MU 2404 Primers | BU-LAMP Primers | |||||||
(+) | (−) | Total | (+) | (−) | Total | (+) | (−) | Total | |
IS2404 PCR (+) | 64 | 7 | 71 | 59 | 12 | 71 | 25 | 46 | 71 |
IS2404 PCR (−) | 7 | 58 | 65 | 4 | 61 | 65 | 3 | 62 | 65 |
Total | 71 | 65 | 136 | 63 | 73 | 136 | 28 | 108 | 136 |
Disease prevalence | 52.21% (43.48 to 60.84%) | 52.21% (43.48 to 60.84%) | 52.21% (43.48 to 60.84%) | ||||||
Sensitivity | 90.14% (80.74 to 95.94%) | 83.10% (72.34 to 90.95%) | 35.21% (24.24 to 47.46%) | ||||||
Specificity | 89.23% (79.06 to 95.56%) | 93.85% (84.99 to 98.30%) | 95.38% (87.10 to 99.04%) | ||||||
Positive Predictive Value | 90.14% (81.89 to 94.87%) | 93.65% (85.02 to 97.46%) | 89.29% (72.53 to 96.34%) | ||||||
Negative Predictive Value | 89.23% (80.32 to 94.39%) | 83.56% (75.15 to 89.52%) | 57.41% (52.97 to 61.73%) | ||||||
Accuracy | 89.71% (83.33 to 94.26%) | 88.24% (81.60 to 93.12%) | 63.97% (55.30 to 72.02%) |