Phenotypic and molecular characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis isolates in Ningbo, China

Table 3 Performance of PncA mutations for predicting PZA susceptibility

Mutation in PncA	PZA susceptibility^a		Total	Sensitivity^b (95% CI, %)	Specificity^b (95%CI, %)	PPV (95%CI, %)	NPV (95%CI, %)
Mutation in PncA	R	S		Sensitivity^b (95% CI, %)	Specificity^b (95%CI, %)	PPV (95%CI, %)	NPV (95%CI, %)
Yes	54	2	56	83.1	95.6	96.43	79.6
No	11	43	54	(71.3–90.9)	(83.6–99.2)	(86.6–99.4)	(66.1–88.9)
Total	65	45	110

^aR, resistant, S susceptible, PPV positive predictive value, NPV negative predictive value, CI confidence interval
^bThe sensitivity and specificity were examined by Wilson score confidence interval method

ISSN: 1471-2334