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Table 3 Performance of PncA mutations for predicting PZA susceptibility

From: Phenotypic and molecular characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis isolates in Ningbo, China

Mutation in PncA PZA susceptibilitya Total Sensitivityb
(95% CI, %)
Specificityb
(95%CI, %)
PPV
(95%CI, %)
NPV
(95%CI, %)
R S  
Yes 54 2 56 83.1 95.6 96.43 79.6
No 11 43 54 (71.3–90.9) (83.6–99.2) (86.6–99.4) (66.1–88.9)
Total 65 45 110     
  1. aR, resistant, S susceptible, PPV positive predictive value, NPV negative predictive value, CI confidence interval
  2. bThe sensitivity and specificity were examined by Wilson score confidence interval method