Table 2 Mutations of PncA gene among MDR-TB isolates
Nucleotide position | Codon Change | A.A change | Mutation Type | TBDReaMDB | GMTV Database | No. of isolates |
|---|---|---|---|---|---|---|
T14 > G | 5. ATC/AGC | ILE5SER | Non-synonymous | Unreported | Unreported | 2 |
T17 > C | 6. ATC/ACC | ILE6THR | Non-synonymous | Unreported | Reported | 2 |
G19 > T | 7.GTC/TTC | VAL7PHE | Non-synonymous | Reported | Reported | 1 |
T20 > G | GTC/TGC | VAL7 GLY | Non-synonymous | Reported | Reported | 3 |
A23 > G | 8. GAC/GGC | ASP8GLY | Non-synonymous | Reported | Reported | 1 |
A29 > C | 10. CAG/CCG | GLN10PRO | Non-synonymous | Reported | Reported | 2 |
A35 > C | 12. GAC/GCC | ASP12ALA | Non-synonymous | Reported | Reported | 1 |
T40 > G | 14. TGC/GGC | CYS14GLY | Non-synonymous | Unreported | Unreported | 1 |
T56 > G | 19.CTG/CGG | LEU19ARG | Non-synonymous | Reported | Unreported | 1 |
G71 > A | 24. GGC/GAC | GLY24ASP | Non-synonymous | Unreported | Reported | 1 |
T100 > G | 34. TAC/GAC | TYR34/ASP | Non-synonymous | Unreported | Unreported | 1 |
A139 > G | 47. ACC/GCC | THR47ALA | Non-synonymous | Reported | Reported | 1 |
A142 > G | 48. AAG/GAC | LYS48GLU | Non-synonymous | Reported | Reported | 1 |
C151 > T | 51. CAC/TAC | HIS51TYR | Non-synonymous | Reported | Reported | 2 |
A170 > C | 57. CAC/CCC | HIS57PRO | Non-synonymous | Reported | Unreported | 1 |
C184 > A | 62. CCG/ACG | PRO62THR | Non-synonymous | reported | Unreported | 1 |
C206 > G | 69. CCA/CGA | PRO69ARG | Non-synonymous | Unreported | Unreported | 1 |
A226 > C | 76. ACT/CCT | THR76PRO | Non-synonymous | Reported | Reported | 1 |
A287 > C | 96. AAG/ACG | LYS96/THR | Non-synonymous | Reported | Reported | 1 |
294–95 | Deletion T | FRAMSHIPT | FRAMSHIPT | Unreported | Unreported | 1 |
C312 > A | 104. AGC/AGA | SER104ARG | Non-synonymous | Reported | Reported | 1 |
G314 > A | 105. GGC/GAC | GLY105ASP | Non-synonymous | Reported | Reported | 1 |
A329 > G | 110. GAC/GGC | ASP110GLY | Non-synonymous | reported | Unreported | 1 |
A345 > C | 115. CCA/CCC | PRO115PRO | Synonymous | Unreported | Unreported | 1 |
T347 > G | 116. CTG/CGG | LEU116ARG | Non-synonymous | Reported | Reported | 1 |
C372 > A | 124. GGC/GGA | GLY124GLY | Synonymous | Unreported | Unreported | 1 |
T374 > G | 125. GTC/GGC | VAL125GLY | Non-synonymous | Reported | Reported | 1 |
392–93 | Insertion GG | FRAMSHIPT | FRAMSHIPT | Unreported | Unreported | 3 |
G394 > T | 132. GGT/TGT | GLY132CYS | Non-synonymous | reported | Unreported | 1 |
C401 > T | 134. GCC/GTC | ALA134VAL | Non-synonymous | Reported | Reported | 1 |
A403 > C | 135. ACC/CCC | THR135PRO | Non-synonymous | Reported | Reported | 1 |
A407 > C | 136. GAT/GCT | ASP136ALA | Non-synonymous | Unreported | Reported | 2 |
A410 > C | 137. CAT/CCT | HIS137PRO | Non-synonymous | Unreported | Unreported | 3 |
G415 > C | 139. GTG/CTG | VAL139LEU | Non-synonymous | reported | Unreported | 1 |
T416 > G | 139. GTG/GGG | VAL139ALA | Non-synonymous | Reported | Reported | 2 |
A424 > G | 142. ACG/GCG | THR142ALA | Non-synonymous | reported | Unreported | 3 |
T464 > G | 155. GTG/GGG | VAL155GLY | Non-synonymous | Reported | Reported | 1 |
T470 > G | 157. GTG/GGG | VAL157GLY | Non-synonymous | Unreported | Unreported | 1 |
A478 > C | 160. ACA/CCA | THR160PRO | Non-synonymous | Unreported | Reported | 2 |
497–98 | Insertion G | FRAMSHIPT | FRAMSHIPT | Unreported | Unreported | 1 |
G538 > T | 180. GTC/TTC | VAL180PHE | Non-synonymous | Reported | Unreported | 2 |