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Table 2 Mutations of PncA gene among MDR-TB isolates

From: Phenotypic and molecular characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis isolates in Ningbo, China

Nucleotide position Codon Change A.A change Mutation Type TBDReaMDB GMTV Database No. of isolates
T14 > G 5. ATC/AGC ILE5SER Non-synonymous Unreported Unreported 2
T17 > C 6. ATC/ACC ILE6THR Non-synonymous Unreported Reported 2
G19 > T 7.GTC/TTC VAL7PHE Non-synonymous Reported Reported 1
T20 > G GTC/TGC VAL7 GLY Non-synonymous Reported Reported 3
A23 > G 8. GAC/GGC ASP8GLY Non-synonymous Reported Reported 1
A29 > C 10. CAG/CCG GLN10PRO Non-synonymous Reported Reported 2
A35 > C 12. GAC/GCC ASP12ALA Non-synonymous Reported Reported 1
T40 > G 14. TGC/GGC CYS14GLY Non-synonymous Unreported Unreported 1
T56 > G 19.CTG/CGG LEU19ARG Non-synonymous Reported Unreported 1
G71 > A 24. GGC/GAC GLY24ASP Non-synonymous Unreported Reported 1
T100 > G 34. TAC/GAC TYR34/ASP Non-synonymous Unreported Unreported 1
A139 > G 47. ACC/GCC THR47ALA Non-synonymous Reported Reported 1
A142 > G 48. AAG/GAC LYS48GLU Non-synonymous Reported Reported 1
C151 > T 51. CAC/TAC HIS51TYR Non-synonymous Reported Reported 2
A170 > C 57. CAC/CCC HIS57PRO Non-synonymous Reported Unreported 1
C184 > A 62. CCG/ACG PRO62THR Non-synonymous reported Unreported 1
C206 > G 69. CCA/CGA PRO69ARG Non-synonymous Unreported Unreported 1
A226 > C 76. ACT/CCT THR76PRO Non-synonymous Reported Reported 1
A287 > C 96. AAG/ACG LYS96/THR Non-synonymous Reported Reported 1
294–95 Deletion T FRAMSHIPT FRAMSHIPT Unreported Unreported 1
C312 > A 104. AGC/AGA SER104ARG Non-synonymous Reported Reported 1
G314 > A 105. GGC/GAC GLY105ASP Non-synonymous Reported Reported 1
A329 > G 110. GAC/GGC ASP110GLY Non-synonymous reported Unreported 1
A345 > C 115. CCA/CCC PRO115PRO Synonymous Unreported Unreported 1
T347 > G 116. CTG/CGG LEU116ARG Non-synonymous Reported Reported 1
C372 > A 124. GGC/GGA GLY124GLY Synonymous Unreported Unreported 1
T374 > G 125. GTC/GGC VAL125GLY Non-synonymous Reported Reported 1
392–93 Insertion GG FRAMSHIPT FRAMSHIPT Unreported Unreported 3
G394 > T 132. GGT/TGT GLY132CYS Non-synonymous reported Unreported 1
C401 > T 134. GCC/GTC ALA134VAL Non-synonymous Reported Reported 1
A403 > C 135. ACC/CCC THR135PRO Non-synonymous Reported Reported 1
A407 > C 136. GAT/GCT ASP136ALA Non-synonymous Unreported Reported 2
A410 > C 137. CAT/CCT HIS137PRO Non-synonymous Unreported Unreported 3
G415 > C 139. GTG/CTG VAL139LEU Non-synonymous reported Unreported 1
T416 > G 139. GTG/GGG VAL139ALA Non-synonymous Reported Reported 2
A424 > G 142. ACG/GCG THR142ALA Non-synonymous reported Unreported 3
T464 > G 155. GTG/GGG VAL155GLY Non-synonymous Reported Reported 1
T470 > G 157. GTG/GGG VAL157GLY Non-synonymous Unreported Unreported 1
A478 > C 160. ACA/CCA THR160PRO Non-synonymous Unreported Reported 2
497–98 Insertion G FRAMSHIPT FRAMSHIPT Unreported Unreported 1
G538 > T 180. GTC/TTC VAL180PHE Non-synonymous Reported Unreported 2
  1. Abbreviations: MDR, multi drug resistance; TBDReaMDB, Tuberculosis Drug Resistance Mutation Database; GMTV, Genome-wide Mycobacterium tuberculosis variation