Table 1 Risk factor associate with pyrazinamide resistance among 110 MDR isolates
Characteristics | No.(%) of isolates | No.(%) of isolates | χ2 | P _value | |
|---|---|---|---|---|---|
| Â | Â | PZAR | PZAS | Â | Â |
|  | (n = 110) | (n = 65) | (n = 45) |  |  |
Sex | |||||
 Male | 77 (70.0) | 41 (63.1) | 36 (80.0) | – | 0.057 |
 Female | 33 (30.0) | 24 (36.9) | 9 (20.0) | 3.626 | – |
Age group | |||||
 <30 | 19 (17.3) | 9 (13.9) | 10 (22.2) | – | – |
 30–59 | 61 (55.4) | 37 (56.9) | 24 (53.3) | 1.047 | 0.306 |
  ≥ 60 | 30 (27.3) | 19 (29.2) | 11 (24.5) | 1.211 | 0.271 |
Permanent resident | |||||
 Yes | 58 (52.7) | 38 (58.5) | 20 (44.5) | – | – |
 No | 52 (47.3) | 27 (41.5) | 25 (55.5) | 2.096 | 0.148 |
Treatment history | |||||
 New case | 45 (40.9) | 21 (32.3) | 24 (53.3) | – | – |
 Re-treated | 65 (59.1) | 44 (67.7) | 21 (46.7) | 4.863 | 0.027 |
Treatment outcome | |||||
 Successful | 42 (38.2) | 19 (29.2) | 23 (51.1) | – | – |
 Poor | 68 (61.8) | 46 (70.8) | 22 (48.9) | 5.393 | 0.020 |
Cavity | |||||
 Yes | 65 (59.1) | 39 (60.0) | 26 (57.8) | – | – |
 No | 45 (40.9) | 26 (40.0) | 19 (42.2) | 0.054 | 0.816 |
Initial sputum smear | |||||
 Negative | 7 (6.4) | 6 (9.2) | 1 (2.2) | – | – |
 Positive | 103 (93.6) | 59 (90.8) | 44 (97.8) | 2.192 | 0.279 |
Genotype | |||||
 Non-Beijing family | 23 (20.9) | 14 (21.5) | 9 (20.0) | – | – |
 Beijing family | 87 (79.1) | 51 (78.5) | 36 (80.0) | 0.038 | 0.845 |
PncA gene mutation | |||||
 Yes | 56 (50.9) | 54 (83.1) | 2 (4.4) | – |  |
 No | 54 (49.1) | 11 (16.9) | 43 (95.6) | 65.787 | 0.000 |
Resistance to | |||||
 SM | 65 (59.1) | 44 (67.7) | 21 (46.7) | 4.863 | 0.027 |
 EMB | 52 (47.3) | 37 (56.9) | 15 (33.3) | 5.937 | 0.015 |
 OFLX | 33 (30.0) | 28 (43.1) | 5 (11.1) | 12.939 | 0.000 |
 LVX | 33 (30.0) | 28 (43.1) | 5 (11.1) | 12.939 | 0.000 |
 KAN | 9 (8.2) | 6 (9.2) | 3 (6.7) | 0.233 | 0.898 |
 AMK | 8 (7.3) | 6 (9.2) | 2 (4.4) | 0.903 | 0.564 |
 CAP | 4 (3.6) | 2 (3.1) | 2 (4.4) | 0.142 | 1.000 |
 PTO | 2 (1.8) | 1 (1.5) | 1 (2.2) | 0.070 | 1.000 |
 PAS | 6 (5.5) | 1 (1.5) | 5 (11.1) | 4.725 | 0.081 |
 Pre-XDR | 32 (29.1) | 25 (38.5) | 7 (15.6) | 6.764 | 0.009 |
 XDR | 7 (6.4) | 6 (9.2) | 1 (2.2) | 1.174 | 0.279 |