Table 2 Clinical characteristics of severely-symptomatic COVID-19 patients admitted to hospital ward or to Intensive Care Unit
From: Vitamin D and COVID-19 severity and related mortality: a prospective study in Italy
Whole cohort (N = 103) | Patients admitted to hospital ward (n = 49) | Patients admitted to Intensive Care Unit (n = 54) | P-value | |
|---|---|---|---|---|
Age, years mean(SD) | 66.12 (14.14) | 68.82 (14.93) | 63.67 (13.00) | 0.064 ‡ |
Males N(%) | 70 (68%) | 28 (57%) | 42 (78%) | 0.025† |
CV diseasesa N (%) | 12 (12%) | 4 (8%) | 8 (15%) | 0.293† |
At least 1 comorbidityb N(%) | 63 (61%) | 25 (51%) | 38 (70%) | 0.044† |
Obesity N (%) | 20 (19%) | 7 (14%) | 13 (24%) | 0.210† |
Diabetes N (%) | 19 (18%) | 7 (14%) | 12 (22%) | 0.300† |
Hypertension N (%) | 52 (50%) | 21 (43%) | 31 (57%) | 0.140† |
25OHD ng/mL mean(SD) | 18.2 (11.4) | 22.4 (12.7) | 14.4 (8.6) | 0.0003‡ |
vitamin D deficiency (25OHD ≤20 ng/mL) N(%) | 64 (62%) | 22 (45%) | 42 (78%) | 0.0006† |
Creatinine μmol/L median [IQR] | 0.86 [0.72–1.04] | 0.93 [0.81–1.04] | 0.80 [0.66–0.95] | 0.008ǂ |
IL-6 pg/mL median [IQR] | 25.00 [13.00–51.00] | 16.00 [8.00–32.00] | 42.95 [19.00–56.00] | 0.0002ǂ |
D-Dimer ng/mL median [IQR] | 2482 [1697–3267] | 2118 [1125–3110] | 2786 [1585–3986] | 0.403 |
C-reactive Protein, nmol/L median [IQR] | 2.16 [0.78–8.21] | 2.67 [0.88–5.82] | 1.81 [0.72–9.83] | 0.872ǂ |
Fibrinogen, g/L mean(SD) | 482.3 (167.4) | 503.6 (144.4) | 463.0 (181.5) | 0.222‡ |
Lactate dehydrogenase, mU/mL median [IQR] | 260.00 [230.00–312.00] | 253.00 [222.00–279.00] | 284.50 [238.00–364.00] | 0.009ǂ |
Leukocytes count, ×109/L median [IQR] | 7.90 [5.50–10.10] | 7.00 [5.20–8.30] | 8.50 [6.10–10.80] | 0.052ǂ |
Neutrophils count, × 109/L median [IQR] | 5.60 [3.30–7.40] | 3.90 [3.10–5.70] | 6.70 [3.80–8.00] | 0.002ǂ |
Lymphocytes count, ×109/L median [IQR] | 1.50 [1.00–2.00] | 1.50 [1.30–2.20] | 1.30 [0.90–1.90] | 0.039ǂ |
Platelets count, ×109/L median [IQR] | 283.00 [214.00–369.00] | 330.00 [276.00–399.00] | 228.00 [186.00–345.00] | 0.0005ǂ |