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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: Clinical and experimental phenotype of azole-resistant Aspergillus fumigatus with a HapE splice site mutation: a case report

Fig. 1

Clinical course of a patient with CPA. The patient was treated with itraconazole (ITC) from August 2009 to July 2010 and with voriconazole (VRC) until December 2011, however, he had repeated haemoptysis during treatment. He underwent left upper lobe and left S6 segment resection surgery in December 2011 and was treated with VRC for 6 months. The patient was then followed up without antifungal treatment, but relapsed in June 2016, and treatment with VRC was initiated again. The sensitive isolate, MF-2046, was obtained from sputum before treatment with VRC, while the resistant isolate, MF-2108, was obtained from sputum during treatment with VRC. Although the MF-2108 isolate was isolated from sputum in September 2016, VRC treatment was continued until November 2018, as respiratory symptoms and radiological findings improved. Since then, the patient has not been treated, but no disease progression has been observed

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