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Table 2 Baseline factors associated with total HIV-1 DNA reduction to 100 copies/106 PBMC level

From: Therapeutic prediction of HIV-1 DNA decay: a multicenter longitudinal cohort study

Variables

Univariate Analysis

Multivariate Analysis

 

RR (95% CI)

P

RR (95% CI)

P

Sex

 

0.921

 

0.921

 Male

1

 

1

 

 Female

0.96 (0.46–2.04)

 

0.96 (0.46–2.04)

 

Age-per 10 years increase

1.02 (0.76–1.37)

0.891

1.02 (0.76–1.37)

0.889

Transmission route

 

0.359

 

0.305

 MSM

1

 

1

 

 Heterosexual

1.06 (0.49–2.30)

0.885

1.15 (0.62–2.13)

0.650

 Bisexual

0.24 (0.03–2.19)

0.203

0.27 (0.03–2.39)

0.241

 Blood

1.33 (0.10–17.37)

0.826

0.85 (0.08–8.97)

0.895

 Others/Unknown

0.35 (0.09–1.41)

0.140

0.35 (0.09–1.31)

0.120

Subtype

 

0.549

 

0.550

 CRF01_AE

1

 

1

 

 C/CRF07_BC/CRF08_BC

1.47 (0.75–2.86)

0.264

1.47 (0.75–2.86)

0.263

 B/B′

0.71 (0.23–2.21)

0.557

0.72 (0.23–2.22)

0.562

 Others/Unknown

1.12 (0.31–4.01)

0.863

1.12 (0.31–4.00)

0.864

Baseline total HIV-1 DNA -per 1 log copies/106 PBMCs

0.07 (0.03–0.16)

< 0.001

0.08 (0.04–0.16)

< 0.001

Baseline HIV-1 plasma RNA-per 1 log copies/mL

1.20 (0.74–1.96)

0.463

1.12 (0.70–1.77)

0.641

Baseline CD4 cell count-per 100 cells/μL

2.11 (1.28–3.48)

0.003

1.72 (1.35–2.20)

< 0.001

Baseline CD8 cell count-per 100 cells/μL

0.92 (0.81–1.05)

0.211

0.97 (0.90–1.04)

0.389

Baseline CD4/CD8 ratio-per 0.1 increase

0.87 (0.64–1.19)

0.391

0.86 (0.63–1.17)

0.340

  1. RR relative risk, CI confidence interval, MSM men who have sex with men, CRF circulating recombinant form, PBMCs peripheral blood mononuclear cells