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Table 2 Baseline factors associated with total HIV-1 DNA reduction to 100 copies/106 PBMC level

From: Therapeutic prediction of HIV-1 DNA decay: a multicenter longitudinal cohort study

Variables Univariate Analysis Multivariate Analysis
  RR (95% CI) P RR (95% CI) P
Sex   0.921   0.921
 Male 1   1  
 Female 0.96 (0.46–2.04)   0.96 (0.46–2.04)  
Age-per 10 years increase 1.02 (0.76–1.37) 0.891 1.02 (0.76–1.37) 0.889
Transmission route   0.359   0.305
 MSM 1   1  
 Heterosexual 1.06 (0.49–2.30) 0.885 1.15 (0.62–2.13) 0.650
 Bisexual 0.24 (0.03–2.19) 0.203 0.27 (0.03–2.39) 0.241
 Blood 1.33 (0.10–17.37) 0.826 0.85 (0.08–8.97) 0.895
 Others/Unknown 0.35 (0.09–1.41) 0.140 0.35 (0.09–1.31) 0.120
Subtype   0.549   0.550
 CRF01_AE 1   1  
 C/CRF07_BC/CRF08_BC 1.47 (0.75–2.86) 0.264 1.47 (0.75–2.86) 0.263
 B/B′ 0.71 (0.23–2.21) 0.557 0.72 (0.23–2.22) 0.562
 Others/Unknown 1.12 (0.31–4.01) 0.863 1.12 (0.31–4.00) 0.864
Baseline total HIV-1 DNA -per 1 log copies/106 PBMCs 0.07 (0.03–0.16) < 0.001 0.08 (0.04–0.16) < 0.001
Baseline HIV-1 plasma RNA-per 1 log copies/mL 1.20 (0.74–1.96) 0.463 1.12 (0.70–1.77) 0.641
Baseline CD4 cell count-per 100 cells/μL 2.11 (1.28–3.48) 0.003 1.72 (1.35–2.20) < 0.001
Baseline CD8 cell count-per 100 cells/μL 0.92 (0.81–1.05) 0.211 0.97 (0.90–1.04) 0.389
Baseline CD4/CD8 ratio-per 0.1 increase 0.87 (0.64–1.19) 0.391 0.86 (0.63–1.17) 0.340
  1. RR relative risk, CI confidence interval, MSM men who have sex with men, CRF circulating recombinant form, PBMCs peripheral blood mononuclear cells