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Table 2 Clinical description and antibiotic therapy of B. pertussis positive and negative index cases

From: Hospital-based prospective study of pertussis in infants and close contacts in Tehran, Iran

   N available Total B. pertussis cases Negative cases P valuea
N = 199 N = 40 N = 159
Cough duration at inclusion (days)
  median (IQR) 199 8 (6-11) 10 (7.5-19.5) 8 (6-10) 0.004
 ≥ 14 days n (%) 199 34 (17.1) 15 (37.5) 19 (12.0) <0.001
Pertussis-like symptoms
 Nocturnal cough n (%) 199 104 (52.3) 22 (55.0) 82 (51.6) 0.698
 Coughing spells n (%) 199 163 (81.9) 34 (85.0) 129 (81.1) 0.570
 Apnea n (%) 199 31 (15.6) 9 (22.5) 22 (13.8) 0.177
 Cyanosis n (%) 199 130 (65.3) 31 (77.5) 99 (62.3) 0.070
 Inspiratory whoop n (%) 199 32 (16.1) 9 (22.5) 23 (14.5) 0.216
 Difficult breathing in n (%) 199 83 (41.7) 17 (42.5) 66 (41.5) 0.910
 Vomiting n (%) 199 49 (24.6) 10 (25.0) 39 (24.5) 0.951
 Post tussif vomiting n (%) 199 57 (28.6) 16 (40.0) 41 (25.8) 0.076
 Good conditions btw cough n (%) 197 139 (70.6) 24 (60.0) 115 (73.3) 0.101
 Abnormal pulm auscultation n (%) 193 26 (13.5) 8 (21.1) 18 (11.6) 0.127
>> sign of upper infection n (%) 23 14 (60.9) 4 (50.0) 10 (66.7) 0.435
>> sign of lower infection n (%) 9 (39.1) 4 (50.0) 5 (33.3)
Temperature
 ≤ 37.5 n (%) 199 190 (95.5) 38 (95.0) 152 (95.6) 0.871
 37.5-38.5 n (%) 9 (4.5) 2 (5.0) 7 (4.4)
Biological data
 Leukocytes (/mm3) median (IQR) 191 10600 (8200-13200) 12900 (10100-17300) 9950 (7800-12400) <0.001
 Lymphocytes (/mm3) median (IQR) 179 6640 (5150-9265) 10080 (6020-14245) 6438 (5073-8421) <0.001
 Hyperlymphocytosis (> 9000/μl) n (%) 179 46 (25.7) 19 (54.3) 27 (18.8) <0.001
 Neutrophiles (/mm3) median (IQR) 179 2772 (1900-4350) 3290 (1800-4862) 2662 (1944-4047) 0.495
 Platelets (x103/mm3) median (IQR) 193 407 (304-506) 474 (320-605) 392 (297-485) 0.040
 Hemoglobin (g/dl) median (IQR) 195 10.5 (9.8-11.5) 11 (9.9-11.6) 10.5 (9.7-11.5) 0.415
 Mean corpuscular volume (MCV) (μ3) median (IQR) 194 87 (82-93) 87 (81-93) 87 (82.5-93) 0.567
 SpO2 median (IQR) 196 95 (95-96) 95 (95-96) 95 (95-96) 0.856
Birth and weight
 Premature birth (< 37 weeks) n (%) 197 22 (11.2) 2 (5.0) 20 (12.7) 0.165
 Low birth weight (< 2.5 kg) n (%) 198 22 (11.1) 2 (5.0) 20 (12.7) 0.169
 Wasting n (%) 188 54 (28.7) 13 (34.2) 41 (27.3) 0.403
 Stunting n (%) 196 23 (11.7) 6 (15.0) 17 (10.9) 0.472
Antibiotic therapy before enrollment
 Yes n (%) 188 120 (63.8) 24 (63.2) 96 (64.0) 0.923
 Macrolides n (%)   82 (43.6) 16 (42.1) 66 (44.0) 0.833
 >> for > 48h before sampling n (%) 82 37 (45.1) 10 (62.5) 27 (40.9) 0.119
Last clinical evaluation
 Time after inclusion (days) median (IQR) 195 14 (13-14) 14 (13-14) 14 (13-14) 0.933
 Full recovery n (%) 195 164 (84.1) 27 (67.5) 137 (88.4) 0.002
 Healing with persistent cough n (%) 195 27 (13.9) 10 (25.0) 17 (11.0) -
 No improvement n (%) 195 2 (1.0) 2 (5.0) 0 (0-) -
Death n (%) 195 2 (1.0) 1 (2.5) 1 (0.7) -
Hospitalization
 Yes n (%) 199 192 (96.5) 39 (97.5) 153 (96.2) 0.696
  1. aP values in bold indicate p < 0.05