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Table 4 RH of clinical progression, defined as the occurrence of an infectious-related or non-infectious related event, from fitting a Cox regression model

From: Inflammation and microbial translocation measured prior to combination antiretroviral therapy (cART) and long-term probability of clinical progression in people living with HIV

PART A. infectious related events

Crude and adjusted relative hazards of infectious-related events in total population

Crude RH

(95% CI)

p-value

Adjusted* RH

(95% CI)

p-value

Adjusted** RH

(95% CI)

p-value

(a) Biomarkers fitted as categorical variables

 LPS, pg/ml

   < =250.8

1.0

 

1.0

 

1.0

 

   > 250.8

0.79 (0.40, 1.56)

0.506

0.67 (0.33, 1.35)

0.262

0.75 (0.36, 1.54)

0.430

  not measured

1.34 (0.77, 2.33)

0.305

1.14 (0.63, 2.06)

0.658

1.19 (0.65, 2.19)

0.567

 sCD14, ug/ml

   < =2.83

1.0

 

1.0

 

1.0

 

   > 2.83

1.45 (0.89, 2.35)

0.134

1.19 (0.71, 1.99)

0.511

1.08 (0.64, 1.82)

0.787

  not measured

1.83 (0.43, 7.67)

0.411

1.08 (0.25, 4.73)

0.918

1.71 (0.35, 8.37)

0.508

 EndoCAb, MMU/ml

   < =36.5

1.0

 

1.0

 

1.0

 

   > 36.5

0.94 (0.59, 1.51)

0.811

0.95 (0.58, 1.55)

0.826

0.98 (0.59, 1.63)

0.942

  not measured

0.48 (0.07, 3.50)

0.469

0.34 (0.05, 2.52)

0.290

0.35 (0.04, 3.13)

0.351

hs-CRP, mg/L

   < =1.51

1.0

 

1.0

 

1.0

 

   > 1.51

1.58 (0.91, 2.74)

0.103

1.64 (0.92, 2.95)

0.096

1.71 (0.94, 3.13)

0.081

  not measured

1.31 (0.69, 2.49)

0.407

1.47 (0.75, 2.87)

0.260

1.49 (0.75, 2.96)

0.250

(b) Biomarkers fitted as continuous variables in the loge scale

 LPS, pg/ml

  per loge higher

0.96 (0.62, 1.49)

0.857

0.85 (0.54, 1.34)

0.486

0.58 (0.31, 1.09)

0.089

 sCD14, ug/ml

  per loge higher

1.21 (0.82, 1.80)

0.344

0.92 (0.57, 1.50)

0.747

1.01 (0.54, 1.90)

0.968

 EndoCAb, MMU/ml

  per loge higher

1.00 (0.76, 1.32)

0.982

1.01 (0.76, 1.35)

0.927

0.95 (0.56, 1.61)

0.857

 hs-CRP, mg/L

  per loge higher

1.09 (0.92, 1.28)

0.316

1.05 (0.89, 1.24)

0.556

1.13 (0.89, 1.43)

0.303

PART B. Non-infectious related events

Crude and adjusted relative hazards of non-infectious related events in total population

Crude RH

(95% CI)

p-value

Adjusteda RH

(95% CI)

p-value

Adjustedb RH

(95% CI)

p-value

(a) Biomarkers fitted as categorical variables

 LPS, pg/ml

   < =250.8

1.0

 

1.0

 

1.0

 

   > 250.8

0.84 (0.42, 1.67)

0.625

0.88 (0.42, 1.85)

0.728

1.08 (0.49, 2.37)

0.856

  not measured

0.72 (0.38, 1.39)

0.327

0.95 (0.47, 1.92)

0.892

1.12 (0.54, 2.34)

0.758

 sCD14, ug/ml

   < =2.83

1.0

 

1.0

 

1.0

 

   > 2.83

0.71 (0.41, 1.25)

0.241

0.69 (0.38, 1.27)

0.232

0.63 (0.34, 1.17)

0.147

  not measured

0.78 (0.11, 5.72)

0.805

0.68 (0.09, 5.21)

0.712

1.16 (0.14, 9.60)

0.889

 EndoCAb, MMU/ml

   < =36.5

1.0

 

1.0

 

1.0

 

   > 36.5

0.52 (0.29, 0.92)

0.026

0.64 (0.35, 1.19)

0.163

0.64 (0.33, 1.22)

0.172

  not measured

0.00 (0.00,.)

0.986

0.00 (0.00,.)

0.987

0.00 (0.00,.)

0.986

hs-CRP, mg/L

   < =1.51

1.0

 

1.0

 

1.0

 

   > 1.51

1.41 (0.75, 2.65)

0.281

1.25 (0.65, 2.43)

0.505

1.30 (0.65, 2.58)

0.454

  not measured

1.04 (0.49, 2.22)

0.921

0.99 (0.46, 2.16)

0.985

0.96 (0.42, 2.16)

0.917

(b) Biomarkers fitted as continuous variables in the loge scale

 LPS, pg/ml

  per loge higher

0.87 (0.56, 1.36)

0.542

0.87 (0.52, 1.44)

0.592

0.89 (0.46, 1.71)

0.730

 sCD14, ug/ml

  per loge higher

1.02 (0.56, 1.86)

0.943

0.95 (0.49, 1.87)

0.887

0.52 (0.18, 1.50)

0.228

 EndoCAb, MMU/ml

  per loge higher

0.68 (0.48, 0.97)

0.031

0.81 (0.56, 1.16)

0.243

1.07 (0.59, 1.91)

0.830

 hs-CRP, mg/L

  per loge higher

1.14 (0.94, 1.38)

0.196

1.05 (0.85, 1.30)

0.643

0.96 (0.73, 1.26)

0.750

  1. Note: a All models (a separate one for each biomarker) adjusted for age, CD4, VL, HCV/HBV, years of cART, duration of HIV infection at starting cART, type of cART started bFurther mutually adjusted for all biomarkers