PART A. infectious related events | Crude and adjusted relative hazards of infectious-related events in total population | |||||
Crude RH (95% CI) | p-value | Adjusted* RH (95% CI) | p-value | Adjusted** RH (95% CI) | p-value | |
(a) Biomarkers fitted as categorical variables | ||||||
 LPS, pg/ml | ||||||
   < =250.8 | 1.0 |  | 1.0 |  | 1.0 |  |
   > 250.8 | 0.79 (0.40, 1.56) | 0.506 | 0.67 (0.33, 1.35) | 0.262 | 0.75 (0.36, 1.54) | 0.430 |
  not measured | 1.34 (0.77, 2.33) | 0.305 | 1.14 (0.63, 2.06) | 0.658 | 1.19 (0.65, 2.19) | 0.567 |
 sCD14, ug/ml | ||||||
   < =2.83 | 1.0 |  | 1.0 |  | 1.0 |  |
   > 2.83 | 1.45 (0.89, 2.35) | 0.134 | 1.19 (0.71, 1.99) | 0.511 | 1.08 (0.64, 1.82) | 0.787 |
  not measured | 1.83 (0.43, 7.67) | 0.411 | 1.08 (0.25, 4.73) | 0.918 | 1.71 (0.35, 8.37) | 0.508 |
 EndoCAb, MMU/ml | ||||||
   < =36.5 | 1.0 |  | 1.0 |  | 1.0 |  |
   > 36.5 | 0.94 (0.59, 1.51) | 0.811 | 0.95 (0.58, 1.55) | 0.826 | 0.98 (0.59, 1.63) | 0.942 |
  not measured | 0.48 (0.07, 3.50) | 0.469 | 0.34 (0.05, 2.52) | 0.290 | 0.35 (0.04, 3.13) | 0.351 |
hs-CRP, mg/L | ||||||
   < =1.51 | 1.0 |  | 1.0 |  | 1.0 |  |
   > 1.51 | 1.58 (0.91, 2.74) | 0.103 | 1.64 (0.92, 2.95) | 0.096 | 1.71 (0.94, 3.13) | 0.081 |
  not measured | 1.31 (0.69, 2.49) | 0.407 | 1.47 (0.75, 2.87) | 0.260 | 1.49 (0.75, 2.96) | 0.250 |
(b) Biomarkers fitted as continuous variables in the loge scale | ||||||
 LPS, pg/ml | ||||||
  per loge higher | 0.96 (0.62, 1.49) | 0.857 | 0.85 (0.54, 1.34) | 0.486 | 0.58 (0.31, 1.09) | 0.089 |
 sCD14, ug/ml | ||||||
  per loge higher | 1.21 (0.82, 1.80) | 0.344 | 0.92 (0.57, 1.50) | 0.747 | 1.01 (0.54, 1.90) | 0.968 |
 EndoCAb, MMU/ml | ||||||
  per loge higher | 1.00 (0.76, 1.32) | 0.982 | 1.01 (0.76, 1.35) | 0.927 | 0.95 (0.56, 1.61) | 0.857 |
 hs-CRP, mg/L | ||||||
  per loge higher | 1.09 (0.92, 1.28) | 0.316 | 1.05 (0.89, 1.24) | 0.556 | 1.13 (0.89, 1.43) | 0.303 |
PART B. Non-infectious related events | Crude and adjusted relative hazards of non-infectious related events in total population | |||||
Crude RH (95% CI) | p-value | Adjusteda RH (95% CI) | p-value | Adjustedb RH (95% CI) | p-value | |
(a) Biomarkers fitted as categorical variables | ||||||
 LPS, pg/ml | ||||||
   < =250.8 | 1.0 |  | 1.0 |  | 1.0 |  |
   > 250.8 | 0.84 (0.42, 1.67) | 0.625 | 0.88 (0.42, 1.85) | 0.728 | 1.08 (0.49, 2.37) | 0.856 |
  not measured | 0.72 (0.38, 1.39) | 0.327 | 0.95 (0.47, 1.92) | 0.892 | 1.12 (0.54, 2.34) | 0.758 |
 sCD14, ug/ml | ||||||
   < =2.83 | 1.0 |  | 1.0 |  | 1.0 |  |
   > 2.83 | 0.71 (0.41, 1.25) | 0.241 | 0.69 (0.38, 1.27) | 0.232 | 0.63 (0.34, 1.17) | 0.147 |
  not measured | 0.78 (0.11, 5.72) | 0.805 | 0.68 (0.09, 5.21) | 0.712 | 1.16 (0.14, 9.60) | 0.889 |
 EndoCAb, MMU/ml | ||||||
   < =36.5 | 1.0 |  | 1.0 |  | 1.0 |  |
   > 36.5 | 0.52 (0.29, 0.92) | 0.026 | 0.64 (0.35, 1.19) | 0.163 | 0.64 (0.33, 1.22) | 0.172 |
  not measured | 0.00 (0.00,.) | 0.986 | 0.00 (0.00,.) | 0.987 | 0.00 (0.00,.) | 0.986 |
hs-CRP, mg/L | ||||||
   < =1.51 | 1.0 |  | 1.0 |  | 1.0 |  |
   > 1.51 | 1.41 (0.75, 2.65) | 0.281 | 1.25 (0.65, 2.43) | 0.505 | 1.30 (0.65, 2.58) | 0.454 |
  not measured | 1.04 (0.49, 2.22) | 0.921 | 0.99 (0.46, 2.16) | 0.985 | 0.96 (0.42, 2.16) | 0.917 |
(b) Biomarkers fitted as continuous variables in the loge scale | ||||||
 LPS, pg/ml | ||||||
  per loge higher | 0.87 (0.56, 1.36) | 0.542 | 0.87 (0.52, 1.44) | 0.592 | 0.89 (0.46, 1.71) | 0.730 |
 sCD14, ug/ml | ||||||
  per loge higher | 1.02 (0.56, 1.86) | 0.943 | 0.95 (0.49, 1.87) | 0.887 | 0.52 (0.18, 1.50) | 0.228 |
 EndoCAb, MMU/ml | ||||||
  per loge higher | 0.68 (0.48, 0.97) | 0.031 | 0.81 (0.56, 1.16) | 0.243 | 1.07 (0.59, 1.91) | 0.830 |
 hs-CRP, mg/L | ||||||
  per loge higher | 1.14 (0.94, 1.38) | 0.196 | 1.05 (0.85, 1.30) | 0.643 | 0.96 (0.73, 1.26) | 0.750 |