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Table 4 RH of clinical progression, defined as the occurrence of an infectious-related or non-infectious related event, from fitting a Cox regression model

From: Inflammation and microbial translocation measured prior to combination antiretroviral therapy (cART) and long-term probability of clinical progression in people living with HIV

PART A. infectious related events Crude and adjusted relative hazards of infectious-related events in total population
Crude RH
(95% CI)
p-value Adjusted* RH
(95% CI)
p-value Adjusted** RH
(95% CI)
p-value
(a) Biomarkers fitted as categorical variables
LPS, pg/ml
   < =250.8 1.0   1.0   1.0  
   > 250.8 0.79 (0.40, 1.56) 0.506 0.67 (0.33, 1.35) 0.262 0.75 (0.36, 1.54) 0.430
  not measured 1.34 (0.77, 2.33) 0.305 1.14 (0.63, 2.06) 0.658 1.19 (0.65, 2.19) 0.567
sCD14, ug/ml
   < =2.83 1.0   1.0   1.0  
   > 2.83 1.45 (0.89, 2.35) 0.134 1.19 (0.71, 1.99) 0.511 1.08 (0.64, 1.82) 0.787
  not measured 1.83 (0.43, 7.67) 0.411 1.08 (0.25, 4.73) 0.918 1.71 (0.35, 8.37) 0.508
EndoCAb, MMU/ml
   < =36.5 1.0   1.0   1.0  
   > 36.5 0.94 (0.59, 1.51) 0.811 0.95 (0.58, 1.55) 0.826 0.98 (0.59, 1.63) 0.942
  not measured 0.48 (0.07, 3.50) 0.469 0.34 (0.05, 2.52) 0.290 0.35 (0.04, 3.13) 0.351
hs-CRP, mg/L
   < =1.51 1.0   1.0   1.0  
   > 1.51 1.58 (0.91, 2.74) 0.103 1.64 (0.92, 2.95) 0.096 1.71 (0.94, 3.13) 0.081
  not measured 1.31 (0.69, 2.49) 0.407 1.47 (0.75, 2.87) 0.260 1.49 (0.75, 2.96) 0.250
(b) Biomarkers fitted as continuous variables in the loge scale
LPS, pg/ml
  per loge higher 0.96 (0.62, 1.49) 0.857 0.85 (0.54, 1.34) 0.486 0.58 (0.31, 1.09) 0.089
sCD14, ug/ml
  per loge higher 1.21 (0.82, 1.80) 0.344 0.92 (0.57, 1.50) 0.747 1.01 (0.54, 1.90) 0.968
EndoCAb, MMU/ml
  per loge higher 1.00 (0.76, 1.32) 0.982 1.01 (0.76, 1.35) 0.927 0.95 (0.56, 1.61) 0.857
hs-CRP, mg/L
  per loge higher 1.09 (0.92, 1.28) 0.316 1.05 (0.89, 1.24) 0.556 1.13 (0.89, 1.43) 0.303
PART B. Non-infectious related events Crude and adjusted relative hazards of non-infectious related events in total population
Crude RH
(95% CI)
p-value Adjusteda RH
(95% CI)
p-value Adjustedb RH
(95% CI)
p-value
(a) Biomarkers fitted as categorical variables
LPS, pg/ml
   < =250.8 1.0   1.0   1.0  
   > 250.8 0.84 (0.42, 1.67) 0.625 0.88 (0.42, 1.85) 0.728 1.08 (0.49, 2.37) 0.856
  not measured 0.72 (0.38, 1.39) 0.327 0.95 (0.47, 1.92) 0.892 1.12 (0.54, 2.34) 0.758
sCD14, ug/ml
   < =2.83 1.0   1.0   1.0  
   > 2.83 0.71 (0.41, 1.25) 0.241 0.69 (0.38, 1.27) 0.232 0.63 (0.34, 1.17) 0.147
  not measured 0.78 (0.11, 5.72) 0.805 0.68 (0.09, 5.21) 0.712 1.16 (0.14, 9.60) 0.889
EndoCAb, MMU/ml
   < =36.5 1.0   1.0   1.0  
   > 36.5 0.52 (0.29, 0.92) 0.026 0.64 (0.35, 1.19) 0.163 0.64 (0.33, 1.22) 0.172
  not measured 0.00 (0.00,.) 0.986 0.00 (0.00,.) 0.987 0.00 (0.00,.) 0.986
hs-CRP, mg/L
   < =1.51 1.0   1.0   1.0  
   > 1.51 1.41 (0.75, 2.65) 0.281 1.25 (0.65, 2.43) 0.505 1.30 (0.65, 2.58) 0.454
  not measured 1.04 (0.49, 2.22) 0.921 0.99 (0.46, 2.16) 0.985 0.96 (0.42, 2.16) 0.917
(b) Biomarkers fitted as continuous variables in the loge scale
LPS, pg/ml
  per loge higher 0.87 (0.56, 1.36) 0.542 0.87 (0.52, 1.44) 0.592 0.89 (0.46, 1.71) 0.730
sCD14, ug/ml
  per loge higher 1.02 (0.56, 1.86) 0.943 0.95 (0.49, 1.87) 0.887 0.52 (0.18, 1.50) 0.228
EndoCAb, MMU/ml
  per loge higher 0.68 (0.48, 0.97) 0.031 0.81 (0.56, 1.16) 0.243 1.07 (0.59, 1.91) 0.830
hs-CRP, mg/L
  per loge higher 1.14 (0.94, 1.38) 0.196 1.05 (0.85, 1.30) 0.643 0.96 (0.73, 1.26) 0.750
  1. Note: a All models (a separate one for each biomarker) adjusted for age, CD4, VL, HCV/HBV, years of cART, duration of HIV infection at starting cART, type of cART started bFurther mutually adjusted for all biomarkers