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Table 2 Comparison of clinical characteristics between group TMP and group TMN during the first visit

From: Clinical findings of Talaromyces marneffei infection among patients with anti-interferon-γ immunodeficiency: a prospective cohort study

Variable

Group TMP (N = 22)

Group TMN (N = 20)

P value

Age, years

52.0 (34.8, 58.0)

54.5 (29.0, 63.8)

0.734

Male sex, no. (%)

14 (63.6%)

13 (65.0%)

1.0

Anti-IFN-γ antibody titer (ng/ml)

926.31 (760.02, 2103.20)

332.40 (243.51,491.89)

<0.001

Time from symptom onset to diagnosis

149.5 (57.2, 272.3)

98.5 (22.3154.5)

0.107

Coexisting respiratory disease, no. (%)

3 (13.6%)

10 (50.0%)

0.019

 Bronchiolitis

0

4 (20.0%)

0.043

 COPD

2 (9.1%)

4 (20.0%)

0.400

 COPD with bronchiectasis

0

2 (10.0%)

0.221

 Asthma

1 (4.5%)

0

0.476

Extrapulmonary organ involvement, no. (%)

18 (81.8%)

11 (55.0%)

0.096

 Skin

10 (45.5%)

3 (15.0%)

0.047

 Lymph node

18 (81.8%)

11 (55.0%)

0.096

 Liver

2 (9.1%)

1 (5.0%)

1.000

 Spleen

2 (9.1%)

0

0.489

 Bone

9 (40.9%)

1 (5.0%)

0.010

Symptoms, no. (%)

 Fever

12 (54.5%)

6 (30.0%)

0.131

 Cough

17 (77.3%)

17 (85.0%)

0.700

 Sputum production

14 (63.6%)

15 (75.0%)

0.514

 Hemoptysis

4 (18.2%)

3 (15.0%)

1.0

 Dyspnea

6 (27.3%)

3 (15%)

0.460

 Chest pain

9 (40.9%)

6 (30.0%)

0.531

 Osteodynia/Arthralgia

7 (31.8%)

3 (15.0%)

0.284

 Wasting

13 (59.0%)

10 (50.0%)

0.757

 Moist rales

6 (27.3%)

8 (40.0%)

0.515

 Pleural effusion

13 (59.1%)

3 (15.0%)

0.005

 Co-infection, no. (%)

12 (55.0%)

4 (20.0%)

0.029

Outcome, no. (%)a

 Cured

0

2 (10.0%)

 Improved

2 (9.1%)

4 (20.0%)

 Ineffective

6 (27.3%)

0

 Recurrence

1 (4.5%)

0

 Death

3 (13.6%)

0

  1. aData were available for 12 patients in group TMP and 6 patients in group TMN during the longitudinal follow-up
  2. Group TMP = anti-IFN-γ autoantibody-positive group
  3. Group TMN = anti-IFN-γ autoantibody-negative group
  4. COPD Chronic obstructive pulmonary disease
  5. NTM Nontuberculous Mycobacterium