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Table 2 Outcomes assessed by the included studies clustered by bacterial phenotype

From: The role of combination therapy in the treatment of severe infections caused by carbapenem resistant gram-negatives: a systematic review of clinical studies

Outcome

Bacterial phenotype

Total 134 studies

A. baumannii 54 studies

P. aeruginosa 7 studies

Enterobacteriaceae 52 studies

Mixed Gram-negative 21 studies

Mortality

 30-day mortality

29

3

24

9

65

 Mortality at other time pointa

10

2

16

7

35

 Attributable mortality

11

1

3

4

19

Adverse effects

 Renal

21

2

9

13

45

 Diarrhea/C. difficile infection

4

3

7

 Neurological

8

1

2

6

17

 Not specified

3

3

3

3

12

 Clinical cure

38

6

19

13

76

 Length of hospital stay

4

2

1

7

 Microbiological cure

37

4

13

11

65

 Resistance development

7

3

1

11

 Re-hospitalization

1

1

  1. aMortality at any time point other than 30-day and in-hospital mortality