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Table 1 Demographic and clinical characteristics of adult patients

From: The role of combination therapy in the treatment of severe infections caused by carbapenem resistant gram-negatives: a systematic review of clinical studies

Patient and infection characteristics

Bacterial phenotype

Total

131 studies

A. baumannii

53 studies

P. aeruginosa

7 studies

Enterobacteriaceae

51 studies

Mixed Gram- negative

20 studies

Age years, median (IQR)

(103 studies provided data)

57 (51–65)

59.5 (46–63)

60 (51–64)

59.5 (51–65)

59.5 (51–65)

Pulmonary illness

20 (10–26)

19 (15–28)

16 (10–23)

21 (12–25)

20 (11–26)

Median frequency % (IQR)

(64 studies provided data)

Neurological illness

13 (8–22)

22 (9–24)

20 (11–28)

17 (9–26)

Median frequency % (IQR)

(36 studies provided data)

Renal illness

23 (18–35)

23 (20–35)

24.5 (22–36)

20 (18–33)

22 (18–35)

Median frequency % (IQR)

(76 studies provided data)

Immunocompromised status

26 (14–44)

31 (15–41)

29.5 (18–47)

32 (15–43)

26 (14–40)

Median frequency % (IQR)

(72 studies provided data)

Infection type, n (%)

 Mixed infection

18 (35)

4 (57)

31 (61)

11 (57)

64 (49)

 Bloodstream infection

13 (24)

0

18 (35)

6 (28.5)

37 (28)

 Ventilator−/Hospital acquired pneumonia

20 (37)

3 (43)

2 (4)

2 (9.5)

27 (21)

 Othera

2 (4)

0

0

1 (5)

3 (2)

Apache II score

18 (15–22)

14 (14–16)

20 (15–21)

19 (19–23)

20 (17–23)

Median (IQR)

(76 studies provided data)

Monomicrobial, n (%)

(79 studies provided data)

13 (26)

3 (43)

12 (23)

6 (27)

34 (26)

Appropriate empiric treatment°

48 (22–67)

Median frequency % (IQR)b

(30 studies provided data)

  1. aOther: Central nervous system infections in A. baumannii group; mediastinitis in Mixed Gram-negative group
  2. bGiven that the paucity of studies providing data, only overall value was computed
  3. IQR Interquartile range